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Summary Of Survival Of The Sickest

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A doctorate holder in human physiology, neurogenetics and evolutionary medicine, Dr.Sharon Moalem makes connections between modern day diseases and how they were necessary for the survival of our ancestors. In his book Survival of the Sickest, Moalem makes many claims, but they are all hypotheses. One of Moalem’s firsts claims is that hemochromatosis, a fairly rare disease today unless one is of Western European descent, is a disease that can cause many complications within the human body due to an iron excess. Moalem claims that hemochromatosis is still in the gene pool and is very common to people of European descent because of the bubonic plague. The plague, a very fatal disease that reared its head in Europe during the 14th century is …show more content…

Moalem states how the " gene for hemochromatosis is the most common genetic variant in people of Western European descent. " (Moalem 2007, pg.2). While hemochromatosis is very common in people of Western European descent, “it is very rare in African American, Asian, Hispanic, Latino or American Indian individuals.” (Coriell Institute for Medical Research, 2015). Thus showing that hemochromatosis most likely shows up in people of European descent. Moalem claims to have an explanation to why hemochromatosis shows up in people of European descent. He claims that it all boils down to the bubonic plague that kill millions of Europeans during the 14th century. Moalem (2007) believed that “the more iron in a given population, the more vulnerable that population is to the plague." This piece of information makes one wonder, if people with hemochromatosis had an excess of iron within their bodies, why weren't they all killed pout by the plague. The answer lies in the diseases itself, hemochromatosis unevenly spreads iron throughout the body and macrophages, a type of white blood cells that protect our immune system and the cells that infections such as the bubonic plague use to gain their way into our immune system, contains lower than normal levels of iron. Proving that people with hemochromatosis do actually have less iron in macrophages. Nouri (2011) says, “It is believed that the mutation results in the absence of the C282Y protein on host cell surfaces, causing an increase in the affinity of cellular receptors for transferrin (an unaffected protein in humans which carries iron in the blood) and hindering transferrin acquisition by pathogens. Yersinia pestis, like other iron-hungry bacteria, thrives in an iron rich environment. And it is thus populated

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