Summary Of The Research. In Their Article, “Differences

904 WordsApr 30, 20174 Pages
Summary of the Research In their article, “Differences in Mouse Maternal Care Behavior – Is There a Genetic Impact of the Glucocorticoid Receptor,” Chourbaji et al. (2011) report a 2*2 factorial research design to determine the effect of mutations in Glucocorticoid Receptor (GR) on the maternal behaviors in two different strains of inbred mice. The experiment was conducted in three main stages. The first stage was the production of GR heterozygous mice of both lab strains under study. The next step was the controlled mating and delivery of the pups for knowing the effect of this mutation. The third step was the observation of the maternal behavior in two strains. No significant differences in the behaviors of two strains were observed and…show more content…
The soundness of theoretical reasoning Chourbaji et al. (2011) described their hypothesis clearly in the introduction. They first justified the possible role of GR abnormalities in the postpartum depression by describing the effect of this receptor in other stressful stimuli. They next described the differences in the emotional responses of different strains that were used in this study and the reason for their use. They then described their hypothesis as the “emergence of a depression-like behavioral profile in GR heterozygous animals, specifically an increase in maternal neglect and/or a reduction of caring behavior” (Chourbaji et al., 2011). Overall, the research is based on sound theoretical reasoning. The appropriateness of the experimental design The experimental design lacks some significant factors that could have resulted in the prominent observation of the emotional changes in the maternal behavior of mice. While it has been confirmed that home-cage observations can be the appropriate ways of knowing the physical or emotional reactivity in mice, there are other ways to analyze the emotional response in mice. Some of these observational strategies also used invasive stimuli but have been used to confirm the respective emotional responses under study. The soundness of mathematics and/or statistical tests The use of General Linear Models (GLM) has not been justified in the paper. Additionally, two-way ANOVA for strain and GR genotype has been
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