Summary and Analysis: 'The Fat-Brain Axis Enters a New Dimension' by Joel Elmquist and Jeffrey Flier

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Introduction The purpose of this essay is to examine the article " The Fat-Brain Axis Enters a New Dimension," by Joel Elmquist and Jeffery Flier. This essay will attempt to explain this article and summarize its key points. Synopsis Elmquist & Flier (2004) investigated some recently discovered literature about the hormone leptin. This article attempted to synthesize some new documented research about how leptin contributes to the activity within the central nervous system. The purpose of this article is to identify the importance of this newly synthesized information and lead it to new discoveries by promoting several well founded research questions. Setting the Argument with Pinto et al. The authors relied heavily on two studies to create their argument. The first study mentioned was the Pinto et al article. In this study, "Pinto and colleagues (5) assessed the acute effects of leptin on synaptic plasticity in the arcuate nucleus of the hypothalamus. The arcuate nucleus is one of the key targets of circulating hormones such as leptin. At least two distinct populations of neurons with opposing actions on food intake residein the arcuate nucleus, " (p.63). Pinto's data is ultimately described as helpful but also created many more questions, probably more than it answered. As Pinto's case is explained , the experiment is briefly mentioned and few details are provided to add any real context to the interpretation. Regardless of this lack of clarity, a new theory

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