Sympathetic Paragangliomas

There is much deliberation concerning phenylephrine and vasopressin working on systolic blood pressure. Both constrict blood vessels, both can lead to bad complications if you give it into a blown IV and phenylephrine will cause pulmonary arterial vasoconstriction as well. Fluid resuscitation was continued while BP was supported with phenylephrine and vasopressin. Phenylephrine was changed

A week after initial admission, the patient is on the medical surgical floor recovering from his transverse colostomy five days ago. At 1200 vital signs are as follows, temperature 99.1; pulse 96; respirations 18; blood pressure 141/69; pulse ox is 94% on 1L NC in AM. The patient appears acutely ill and lays in bed with his eyes closed even when family comes into the room to check on him. He is alert and oriented to person, but not place or situation. He appears lethargic and is slow to respond to questioning, this appears to be due to recent administration of pain medication. Pupils are equal round and reactive to light and grips are week bilaterally in hands. Abdomen is firm, distended, and non-tender. Colostomy site appears to be

The patient wakes up after few minutes of the procedure with some dizziness (anesthetic effects) and becomes alert after few hours and can resume normal activities.

He does not smoke or drink. He is married with two children. There is no cancer within the family. No known drug allergies. Current home medications are Omeprazole 20 mg 1 tablet daily, Ondansetron 4 mg 1 tablet daily, Oxycodone 5 mg 1 tablet p.r.n. for pain. He was recently started on FOLFOX with chemotherapy. Currently patient has been on Hydrocodone, morphine IV for pain, Ondansetron IV for nausea, and Lovenox SC for DVT prophylactic. Patient has been not taking any blood pressure or diabetes medication as per hospital record which may lead to raise in blood glucose level and blood pressure (due to pain) postoperatively. Close monitoring of vital signs, pain scale and CBG will be the important in patient’s care. Due to his extensive metastatic condition, obesity and being prediabetic makes his overall prognosis poor with high chance of having complications postop including fistulas, bowel injury, infection, slow wound healing and

Paraneoplastic syndromes are rare disorders triggered by a person's immune system in response to a cancerous tumor. Paraneoplastic syndromes can affect many areas of the body systems, including the nervous system, hormone (endocrine) system, skin (dermatologic) system, blood (hematologic) system, and joints (rheumatologic) system.

The preanesthetic drug consisted of 0.1 to 0.2 mg / kg of midazolam administered orally 35 minutes before surgery. Anesthetic induction was performed with 0.2 to 0.3 mg / kg of etomidate, 3 to 5 μg / kg of fentanyl, 0.05 mg / kg midazolam and 0.1 mg / kg intravenous pancuronium. Maintenance was performed with isoflurane combined with a mixture of oxygen and compressed air, and fentanyl if necessary. During cardiopulmonary bypass, additional doses of midazolam and pancuronium were used on demand.

Paraneoplastic syndrome is a set of signs that happens from cancer but is not due to the local presence of cancer cells.

Pheochromocytoma is an adrenal gland tissue tumor. (PubMed) This growth is a result of excessive release of catecholamine’s (hormones). Norepinephrine and epinephrine are the primary hormones secreted while some can produce dopamine. (Medscape) These increased chemicals in the body can influence the persons “heart rate, blood pressure and metabolism”. (PubMed) If not treated these tumors affect the cardiovascular system and can lead to the development of “life threatening hypertension”. (Medscape) These tumors can be seen as a single mass or multiple tumors and can appear unilateral or bilateral in the body. (PubMed) Thirty percent of pheochromocytoma cases are found to be heredity where ten genes have been linked to the condition. Ten percent of pheochromocytomas are malignant and the most common sites of metastasis include “liver, bone and lymph nodes”. (Medscape)

Propofol is a hypnosis which is used to keep the patient sedated during the surgery this also used to keep patients sedated (Stonebridge, 2012). The most common physiological effects of Propofol are the local pain during the injection, eyes rolling back; coughing after anaesthesia, arching body spasms, muscle jerks, muscle twitching, slow heartbeat, hot flushes, increased breathing, hiccups, and periods of not breathing this is when the anaesthetist oxygenates the patient since the patient is sedated. Low blood pressure is also a side effect which shows on the monitor that the blood pressure levels have dropped once the Propofol has been injected (Stonebridge, 2012). Another common side effect is increased levels of fat in the blood, which

According to Silva, the biggest complications post-surgery are hypertension, cardiac output changes, pulmonary hypertension, pneumothorax, kidney failure and many other complications. These risks are the reason why nursing care is so important, and that it is important that the nurse only be assigned to this patient. Also when giving the best care to the patient, it is important that the nurse know these risks, and the signs and symptoms in order to alert the surgeon if any of these complications occur. Silva says that with this knowledge of the surgery and complications, the nurse can acquire a better plan of care and implementation of effective interventions to obtain a better outcome. It is also pertinent that the nurse follow protocol that is set in place to provide the safest care based on evidence based practice (Silva et al, 2016). The role of the nurse is one of the major roles of the health care team solely on the fact that the nurse is the first to assess the patient and to identify feeling and perceptions that the patient and family has in the critical care

This condition is seen when a hemangioma is located in segment IV or close to the hepatic hilium (20).

Both systems usually perform on the same organ and produce the same action potentials, yet their functions are diverse and they compete with one another (Appendix 3). The sympathetic nervous system prepares the body for emergency situations while the parasympathetic nervous system maintains conserving functions when the body is at rest. Parasympathetic ganglia occur individually in the tissues and organs, however sympathetic ganglia occur on either side of spinal cord as two lateral chains. Preganglionic fibers of sympathetic nervous system arise from thoracic and lumbar segments of spinal cord, whereas that of parasympathetic nervous system arises from the midbrain and sacral segments of the spinal cord. Overall effect of sympathetic nervous

A detailed history and clinical exam with a thorough neurological exam aid in the diagnosis. A CT scan of the head to visualize the tumour or a Gadolinium-enhanced MRI that has a higher sensitivity to visualize the cranial nerves could be performed to confirm diagnosis (Marzo, Zender, & Leonetti, 2009). Electrical testing of the facial nerve could assist in determining the severity and extent the tumour is impeding function (Marzo, Zender & Leonetti, 2009).

Inherited pheochromocytomas may be isolated (inherited as an autosomal dominant trait) or a component of hereditary tumor syndromes – primarily multiple endocrine neoplasia (MEN) 2A and 2B and von Hippel-Lindau (VHL) disease, the familial paraganglioma syndromes and, in rare instances, MEN 1, neurofibromatosis (NF) type 1 and the tuberous sclerosis

Paraganglioma is a rare neoplasm of neuroendocrine origin which may develop at many different anatomical sites including head and neck, thorax, and abdomen. The occurrence of paraganglioma in lower spine is rare, but well established as one of the differential. The investigation of choice pre-operatively is magnetic resonance imaging4, which usually shows a very well circumscribed partially cystic mass which is iso- or hypointense to spinal cord on T1-weighted images, and hyperintense on T2-weighted images4. These MRI features are similar to other cauda equine tumors such as ependymoma2. However sometimes MRI may show serpentine congested ectatic blood vessels with “cap sign” (a low intensity signal rim) on T2-weighted images which are considered diagnostic for paragangliomas2,7.