Symptoms And Diagnosis Of Schizophrenia

Many people get it confused with a different disorder called Multiple Personality Disorder however it is a completely different disorder. While no one knows the true cause of schizophrenia, experts speculate that a combination of genetics and environmental causes are at play, the environmental factor being experiences from the womb and outside stimuli during childhood. One clue to the cause of schizophrenia is that the majority of antipsychotic medication that improves symptoms block the dopamine receptor D2 which reduces dopamine levels in neurons. This suggests that schizophrenia has something to do with increased levels of dopamine. These medications are not universally nor completely effective and don’t work for everyone with schizophrenia which adds to the confusion. This means that there’s probably more to do than the D2 receptors. Interestingly one of the most effective drugs, Clozapine, is a weak D2 antagonist suggesting that other nerve transmitter systems like norepinephrine and serotonin and GABA are involved. Twins studies support for a genetic basis as well, even though there haven 't been any specific gene conclusively linked to schizophrenia yet. Finally another important set of clues involving the epidemiology is that schizophrenia happens more to men than with women with onset in the mid twenties for men while late twenties for women. Also the clinical signs for schizophrenia are less severe for women. This difference may be due

Expert’s reason that unevenness in the complicated interconnected chemical responses of the brain connecting the neurotransmitters dopamine and glutamate, and maybe others, performs a part in schizophrenia. Neurotransmitters are elements that permit brain cells to interconnect with each other. Experts are acquiring more about brain chemistry and its connection to schizophrenia. Similarly, in small methods the brains of people with schizophrenia appear diverse than those of healthful people. For instance, fluid-filled holes at the middle of the brain, called ventricles, are greater in certain people with schizophrenia. The brains of people with the disorder similarly manage to have less grey matter, and certain

Majority of cases begin in adolescence and adulthood. The peak age range would be eighteen to thirty year olds. As far as we know it is very rare for a child to have schizophrenia. The age for schizophrenia to appear differs by gender. Women tend to be diagnosed in between twenty and twenty-four. There is a second rise in numbers for women. The second rise begins after the age of forty. Men tend to get it in their twenties. After the age of thirty-five the number of men who develop schizophrenia tends to drop, thus males more likely to have early onset compared to women. “Gender differences may be related to women having more mood disorder and anxiety diagnosis leading to milder forms of schizophrenia going undiagnosed,” (Butcher, 2014). Gender can play a big role when diagnosing schizophrenia.

Genetics can cause differences in brain chemistry and biochemistry may be important in the development and maintenance of schizophrenia. The dopamine

Research by Johnstone in 1994, explained the biological approach of interventions, explanation and treating of schizophrenia patients (Hansell & Damour, 2005). In studies of Fisher in 2001, discoveries that the brain had more dopamine receptors know as B_2 receptors in a person suffering from schizophrenia, than a non-suffer (Hansell & Damour, 2005). Biological findings of schizophrenia suggest that a genetic factor was hereditary, but not conclusive because the element of environment does make a difference (Hansell & Damour, 2005).

Schizophrenia is a psychotic disorder characterized by distorted thinking, impaired emotional responses, poor interpersonal skills and a distortion of reality. It is the most common of psychotic disorders that, in most countries around the world, affects around 1 per cent of the population. In terms of explanations for the disorder, two central types of explanations arise – psychological explanations and biological explanations. Whereas psychological explanations tend to focus on cognitive, emotional and environmental factors that may cause the disorder, biological explanations tend to focus on genetic, biochemical and neuro-anatomical factors as the cause of the

According to James G. Hollandworth of the University of Southern Mississippi, schizophrenia is primarily characterized by a disintegration of reality perception, consciousness, and thought process which results in a debilitated proficiency in social and professional faculties (Hollandworth, 1990). While schizophrenia can most arguably be classified as a predominantly genetic affliction, there are others factors which can contribute to its development even without a genetic predisposition. These elements include birth defects such as hypoxia and low birth rate, neuroanatomical anomalies, viral infections, along with low IQ and cerebral atrophy (Hollandsworth, 1990). While these components in themselves are not sufficient enough to cause the disorder, they result in an increased risk for developing the disease. One theory for the cause of schizophrenia that has been studied with great validity is the dopamine hypothesis. This theory postulates that schizophrenia is caused by an overabundance of the dopamine-dependent areas of the brain causing an imbalance that affects the entire system (Hollandsworth, 1990). For this reason many of today’s schizophrenia treatment drugs inhibit dopamine receptor activity in an attempt to return it to its natural equilibrium. Although even with advances in modern science and new drugs being developed every day, the illness is still only treatable and its symptoms still emerge even

Schizophrenia is a psychological disease with an unknown treatment. Its onset starts in early adult hood on average. There are many studies showing links to genetics and environmental causes. In this paper I will discuss many of the signs and symptoms of schizophrenia along with how it is diagnosed, imaged with MRI, and the difficulty in treating this disease. More treatments for schizophrenia may be revealed with the further advancement of imaging technology. Schizophrenia is a disease that affects the most complex structure in the human body, the human brain. The more research that is continued on the smaller segments of the different areas of the brain with imaging modalities the closer we get to

Currently there are no cures for schizophrenia, but the symptoms are helped by taking antipsychotic medication. The symptoms experienced by those with schizophrenia are grouped in to three categories: negative symptoms, positive symptoms, and cognitive symptoms (Regier 1993, p.92). The positive symptoms include, hallucinations, delusions, unusual or dysfunctional ways of thinking, agitated body movements. Negative symptoms include, flat affect, reduced pleasure in everyday life, difficulty sustaining tasks, and reduced speech. Cognitive symptoms include, disruption in executive functioning and working memory, as well as reduced ability to concentrate. The etiology of schizophrenia is still debated by psychologists and neuroscientists, but factors such as neuroanatomy, and environmental influences are believed to play a key role. A genetic predisposition to schizophrenia has been established by researchers, but it remains unclear what causes the phenotype to be expressed. The most agreed upon cause of schizophrenia refers to the diathesis-stress model, which explains schizophrenia as a response to an individual’s allostatic load becoming too much for the brain to cope with. Another popular explanation amongst neuroscientists is the dopamine

Schizophrenia is a heterogeneous illness that may involve several pathophysiological gender differences. For men and women incidence risk peaks between 20-29 years of age, and women also have a second risk peak between 30–39 years of age. Negative symptoms including low motivation and withdrawal are more frequent in men and appear up to six years before diagnosis (Hafner, 2005; Hafner et al., 1993; Morgan et al., 2008). Women exhibit greater levels of depression and positive symptoms including sexual inappropriateness, impulsivity and delusions (Mendrek et al., 2015; Van der Werf et al., 2014). Sex differences in either age of onset or prevalence of negative symptoms are not as evident in patients that have a family history of schizophrenia (Bergen et al., 2014; Hafner et al., 1998).

Schizophrenia is a disorder that has an effect on about 25 million people around the world (Myers, 2010). Schizophrenia is a brain damage, naturally created by the human body, that is caused by the genetically determined vulnerability of the blood-brain barrier (Voronov, 2013). This psychiatric disorder, like most others, is characterized by changes in behavior, thinking, reduced ability to feel normal emotions, and mood (Abad et al., 2011). The unique thing about schizophrenia is that the symptoms are split into two different sections: positive symptoms (the presences of behaviors and or feelings that are not usually present in humans) and negative symptoms (the lack of behaviors and or feelings that are usually present in humans). Positive symptoms are characterized by the patient having delusions and or hallucinations while negative symptoms are characterized by the patient having affective flattening, alogia, avolition, anhedonia, and asociality (Nasrollahi et al., 2012). Although these are general symptoms for schizophrenia, the symptoms differ between genders.

Biological theorists believe that individuals may have a genetic predisposition for the schizophrenia if a close family member has been diagnosed with the disorder. Stress during adolescent years seems to provoke the disorder among individuals who have a family history of the disorder. In addition, this theory suggests biochemical abnormalities related to the dopamine neurotransmitters may also contribute to the illness as the brains neurotransmission of the dopamine is too frequent in occurrence (Comer, 2005). CAT and MRI scans have also indicated that abnormal brain structuring may also play a role in the development of schizophrenia due to a common occurrence of enlarged ventricles within schizophrenia sufferers (Comer, 2005). Various parts of the brain may not develop for function properly which seems lead to Type II schizophrenia. Studies have also pointed towards the idea that exposure to certain viruses before birth may lead to the eventual development of schizophrenia (Comer, 2005).

Over the years, experiments have produced evidence to suggest that dopamine plays a role in the development of Schizophrenia (Howes, McCutcheon, & Stone, 2015). Dopamine is a neurotransmitter that is produced in the substantia nigra and ventral tegmental regions of the brain. The belief that dopamine was involved in Schizophrenia arose after multiple studies performed with compounds produced an increase in extracellular concentrations of dopamine (Lieberman, Kane, & Alvir, 1987). The patients that were administered these compounds had similar symptoms to those observed from patients who were diagnosed with Schizophrenia (Lieberman et al., 1987).

Schizophrenia is sometimes considered the most devastating of the mental illnesses because its onset is early in a patient’s life, and its symptoms can be destructive to the patient and to the patient’s family and friends. Although schizophrenia is usually discussed as if it were a single disease, this diagnostic category can include a variety of disorders that present with somewhat similar behavioral symptoms. Schizophrenia probably comprises a group of disorders with heterogeneous causes and definitely includes patients whose clinical

Schizophrenia is also known as split personality disorder and it affects men extra recurrently in contrast to women. A number of aspects play decisive task in aggravating the symptoms of this disorder and these issues are genetic parameters, early environment, neurobiology, physiological and social processes. Some drugs also contribute a petite portion in making the condition of the patient poorer.