Symptoms And Symptoms Of Diseases

Malaria has been in existence for thousands of years. Many historical records show that it has affected human civilization greatly by plaguing and causing mass death. The earliest record can be traced back to 2700 BC in China (Cox, 2002). It has been long associated with swamps and insects for hundreds of years but often believed to be the air from swamps causing the plague. The term malaria rooted from two Italian words ‘mala’ and ‘aria’ which literally means bad air. Humanity did not know the true nature of the long thought disease until 1894 when a Scottish physician, Sir Ronald Ross, discovered that it was actually the parasite in mosquito that is causing the malaria.

Malaria has been a major life-threatening disease for thousands of years, and continues to threaten millions of lives around the world. It infects approximately 219 million people each year, mostly poor women and children. What is striking about malaria is the fact that it has the worse effect on those with the least ability to fight the disease. The Republic of Cuba believes that malaria prevention, treatment, and research efforts must be accelerated to eliminate the burden of this disease across Africa, Asia, the Americas, and any country or territory at risk of malaria transmissions.

Malaria is a disease that affects nearly 600 million people and causes more than a million deaths a year, the most coming from children under five. This disease is regularly found in more than 100 countries around the world and affects 40% of the world’s population. It is most commonly transmitted by an infected Anopheles mosquito. The most deadly form of malaria is known as Plasmodium falciparum because almost all deaths from malaria are caused by this specific one. Some of the symptoms that are affiliated with this strand of malaria are the destruction of red blood cells along with complications with the kidneys, lungs, and brain. In more serious cases, it can cause permanent neurological effects and even death. As the Nobel Assembly said at the announcement of the Nobel Prize in Physiology or Medicine, “Diseases caused by parasites have plagued humankind for a millennium and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing”. Youyou Tu, one of the winners of the prize, discovered Artemisinin, “a drug that has significantly reduced the mortality rates for patients suffering from malaria by killing the malaria parasites an early stage of their development.”

Cerebral malaria is characterized by swelling of the brain, which is a result of parasite-filled red blood cells blocking small blood vessels to the brain. A much higher mortality rate is associated with cerebral malaria than common malaria, but not every case of Plasmodium falciparum leads to a breach of the blood-brain barrier, and consequently, cerebral malaria. Children five years and lower are far more susceptible to contracting cerebral malaria, with an annual figure of roughly 575,000 cases occurring in children. Source

Before the research I knew malaria is a disease which occurs mostly in poor, tropical and subtropical areas of the world. I also knew people get malaria by being bitten by an infective mosquito.

There have been many attempts at preventing malaria, none of which have been very successful. These have usually involved protecting human beings from mosquitoes, the dreaded carriers

Annually, 200 million malaria cases are contracted and of these, 90% occur in Sub-Saharan Africa. Approximately one million people die annually, making plasmodium falciparum the most deadly parasitic disease. Contraction of plasmodium falciparum begins when a female Anopheles mosquito injects sporozoites, an early form of plasmodium falciparum, into the host. This sporozite is then transported to the human liver where it undergoes asexual reproduction producing merozoites. The merozoites invade other liver cells and enter the host’s bloodstream, where they invade erythrocyte. After the infection of the erythrocyte, the merozoite is transformed into a trophozoite, which then begins asexual reproduction near the nucleus to form a schizont in the erythrocytic cell. The schizont then asexually reproduces to produce mononucleated merozoites. When the erythrocytic cell ruptures due to the 3,000-4,000 merozoites produced, symptoms of fever and chills are induced within the host. This life cycle is extremely damaging to children; persons under the age of 5 account for 86% of malaria fatalities. Malaria has other characteristic effects, such as yellowing of the skin/eyes (jaundice), sweating, vomiting, weakness, and nausea. Current mortality rates in Africa are 9.33% per 1000 children, which represent 28.2% of all fatalities for those under five. The story changes dramatically as the host

Plasmodium a single-cell parasitic protozoa is transmitted to humans via the bite of an infected female Anopheles species mosquitoes. This can lead to potentially fatal parasites, rapidly multiplying in the liver attacking red blood cells resulting in symptoms arising from cycles of fevers, chills, severe headaches, vomiting, jaundice and diarrhoea. One major disastrous symptom includes sweats accompanied by anaemia, cause damages to vital organs and interruption of blood supply to the brain, which could result in incurable illness leading to fatal death. In very severe cases it can cause seizures, comas or even death. Symptoms usually present between ten to fifteen days after the initial infection. Unlike other diseases, Malaria can represent in people months or even years later. Death rate is approximately 1%-5% due to the spread of Malaria in Afghanistan, affecting each and everyone.

It has been estimated that 609 million people in Africa are at risk of having malaria (Mabaso et al 2007, p. 35). Almost 34% of the populations in Zambia live in endemic risk areas, while 48% of the populations are in epidemic risk (Guerra et al., 2008, p.54; WHO

Symptoms of malaria includes headache, fatigue, muscle aches, and abdominal discomfort followed by fever. Sometimes malaria may also cause diarrhea, anemia, nausea, vomiting, enlarged lever and jaundice. Failure to prompt treatment might cause mental confusion, kidney failure and death. Hypoglycameia and severe anemia is quite common in children. In pregnant women, malaria leads to intrauterine growth retardation, low birth weight, and indirect mortality from abortion, as well as increases infant mortality.

People infected with malaria often experience fever, chills, and flu-like illnesses and then they may develop severe complications and die if left untreated.

Around 300-600 million people suffer from malaria each year, and over one million people die from this disease every year, mostly children younger than five. This disease is endemic to over 100 countries in Africa, Asia, Latin America, the Middle East, and the South Pacific, almost 40% of the world population. Malaria is caused by a parasite that is transferred by the bite of an infected female Anopheles mosquito. The most deadly form of malaria is known as Plasmodium falciparum because almost all deaths from malaria are caused by this specific one. In addition to being the deadliest form of malaria, Plasmodium falciparum destroys red blood cells along with causing complications with the kidneys, lungs, and brain. In more serious cases, it can cause permanent neurological effects, and even death. As the Nobel Assembly said at the announcement of the Nobel Prize in Physiology or Medicine, “Diseases caused by parasites have plagued humankind for a millennia and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing”. Youyou Tu, one of the winners of the prize, discovered Artemisinin, a drug that has significantly reduced the mortality rates for patients suffering from malaria by killing the malaria parasites an early stage of their development.

Around 300-600 million people suffer from malaria each year, and over one million people die from this disease every year, mostly children younger than five. This disease is endemic to over 100 countries in Africa, Asia, Latin America, the Middle East, and the South Pacific, almost 40% of the world population. Malaria is caused by a parasite that is transferred by the bite of an infected female Anopheles mosquito. The most deadly form of malaria is known as Plasmodium falciparum because almost all deaths from malaria are caused by this specific one. In addition to being the deadliest form of malaria, Plasmodium falciparum destroys red blood cells along with causing complications with the kidneys, lungs, and brain. In more serious cases, it can cause permanent neurological effects and even death. As the Nobel Assembly said at the announcement of the Nobel Prize in Physiology or Medicine, “Diseases caused by parasites have plagued humankind for a millennium and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing”. Youyou Tu, one of the winners of the prize, discovered Artemisinin, a drug that has significantly reduced the mortality rates for patients suffering from malaria by killing the malaria parasites an early stage of their development.

Malaria thrives in warm and human areas that have bounty stagnant water sources ideal for breeding and egg nesting. Once bitten by a mature anopheles mosquito the incubation time between infection and showing symptoms is usually between 6-7 days (Patricia Schlagenhauf-Lawlor, & Funk-Baumann, M., 2005, pg. 10)(1). The common symptoms of malaria like chills, headache and perfuse diaphoresis to name a few, exacerbate due to parasitic replication and destruction of the bodies RBC. Once the cell is destroyed the merozites from the RBC disperse throughout the

Malaria is a disease of humans that is caused by the protozoa Plasmodium species and is transferred through the bite of infected female anopheles mosquito. The various species that cause infection in man include Plasmodium (P.) falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. The symptoms of malaria include but not limited to cold, elevated temperature, tiredness, general body weakness, and muscle pains. Symptoms show within 28 days after a bite by the female anopheles mosquito, but in case of P. vivax, relapse could still occur up to five years after the initial infection (Walker and Colledge 2014). Various antimalarial medications are