Symptoms And Symptoms Of Krabbe 's Disease

968 Words Oct 23rd, 2014 4 Pages
Krabbe’s disease has many signs and symptoms. There are three stages of this condition in infantile form. Stage 1: The infant is seemingly normal and healthy for the first couple months after birth. However during early onset of this disease, the child has signs of incoordination, vomiting, irritability, unexplained fevers and stiff posture. Initial symptoms that may occur are seizures (Wenger 2000). There is slight developmental regression and behavioral abnormalities, in particular, displaying hypersensitivity to sound and touch (ORDR). Throughout this stage, the Cerebrspinal Fluid (CSF) protein concentration at this point is significantly increased (Wenger 2000). The CSF is a liquid that bathes the brain and spinal cord. Its function is to cushion the brain and spinal cord, protecting against injury. It also circulates chemicals and certain nutrients that are filtered from the blood and it also removes waste products from the brain (Lantos 2011).
The second stage of Krabbe’s disease involves aplasia and hypoplasia, which is a defective development of the abdominal wall musculature. There is also hypertonia, which is damage to the Central Nervous System (CNS). The CNS is the brain and the spinal cord, which controls most of the functions of the body and mind. There is also visual impairment, sensorineural hearing loss (SNHL), cognitive impairment, and electromyography (EMG) abnormalities (ORDR). These symptoms vary from person to person (Wenger 2000). Some less common…
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