Symptoms And Treatment Of Cancer

1643 WordsNov 28, 20167 Pages
Introduction: HepG2 is a recurrent cell line that contains liver carcinoma cells which are derived from a 15-year-old Caucasian male who had a well-differentiated hepatocellular carcinoma (HepG2 n.d.). Cancer has been defined as undisciplined growth of aberrant cells (American cancer society 2015). There were 14.1 million cancer cases in 2012 globally, and it is predicted to increase to 21.7 million new cancer cases by 2030 (American cancer society 2015). Hepatocellular carcinoma (HCC) is considered the most prevalent leading form of liver cancer (Sanyal et. al 2010 and Raphael et. al 2012). Those authors have emphasized that 90% of HCC cases have resulted due to cirrhosis. Chemotherapy is used to destruct the growth of cancer cells by preventing them from dividing and growing, more specifically, it works by induction apoptosis (Nordqvist 2015). Most anticancer drugs tend to activate the inactivated apoptosis pathway or modify detective apoptosis genes such as cisplatin and 5-fluorouracil (5-FU) (Hassan et al. 2014). Cisplatin is platinum drugs (Rafi 2006:48). While 5-FU is antimetabolites drugs (Rafi 2006:51). Those two drugs are considered the first-line therapy for cancer (Haydon 2015). Apoptosis is highly genetically regulated program that is responsible for removing unwanted cells such as genetically mutated cells, damaged, or virus-infected cells (Hassan et al. 2014 and Hingorani et al. 2011). Apoptosis is required to maintain healthy multicellular organisms.

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