VULVAR CROHN`S IN A PREPUBERTAL GIRL ON INFLIXIMAB Key words Vulvar Crohn`s. Crohn`s disease. Infliximab. Pre pubertal girls. Abstract Crohn`s disease is an inflammatory bowel disease. It often manifests as chronic diarrhea, abdominal pain, weight loss and blood in the stool. It usually involves any part of the gastrointestinal tract and sometimes presents with extra intestinal manifestations like uveitis, dermatitis, arthritis and anemia. Extra intestinal findings like Vulvar lesions are less commonly seen and even more rarely seen in pre pubertal girls. Vulvar Crohn`s can present as labial swelling initially and lead to ulcer formation, if not treated promptly. Crohn`s is treated with aminosalicylates, glucocorticoids and Infliximab (IFX) as induction therapy and aminosalicylates, glucocorticoids, antibiotics, methotrexate, IFX and Azathioprine as maintenance therapy. We present a 10 year old girl who presented with Vulvar Crohn`s while being treated with IFX for Crohn`s disease of the rectum and perianal area over a period of more than two years. Introduction Extra intestinal manifestations of Crohn`s disease (CD) could affect up to 35% of patients (1). Over 50% of patients with CD are women(2) and gynecological involvement of CD, besides fistulas arising from gastrointestinal tract, were already mentioned in the first reports of cutaneous CD in 1965(3) Vulvar CD is a rare condition, with 101 cases reported since 1965(4). It can also be seen in pre pubertal girls like
Complications of Crohn’s may include bowel obstructions, ulcers, fistulas, malnutrition, anal fissures, colon cancer and other health problems. The bowel may become thickened and narrowed disallowing digestive contents to exit
While symptoms differ from patient to patient, some may be more common. Symptoms consist of Diarrhea, bleeding out of the rectum, serious need to move bowels, Stomach cramps along with pain, Sensation of incomplete evacuation, Constipation, Fever, Loss of appetite, Weight Loss, Fatigue, Night sweats, and Loss of normal menstrual cycle. Crohns Disease affects the area of the small intestine and the colon. Diagnosis consist a standard physical exam of your body followed by some basic questions to help physicians learn more about your general health, diet, family history, and environment. After the basic procedures are done there will be a couple of laboratory tests done to study bloody stool, as well as X-rays of the upper and lower GI
I was a 14 year old freshman in high school when I started getting sick. I was always a pretty healthy kid who had perfect attendance records UNTIL that year. The extreme fatigue and weight-loss was the main sign to my mom that something was seriously wrong. Around January of 2010 I had a colonoscopy to confirm what my doctor already believed. I have Crohn’s Disease.
Crohn’s disease is a chronic condition that affects a person’s digestive system with no known cause. When Crohn’s disease strikes, it can affect any part of your digestive system ranging from your mouth, all the way to your anus. Crohn’s disease is chronic and there is no known cure for this condition. So basically, once someone is diagnosed with this condition, they might as well get used to living out the remainder of their life being affected by Crohn’s disease. Crohn’s is not, shall we say, “constant”. The symptoms happen on and off in what are usually called “flare-ups”.
Crohn 's disease is one of two conditions referred to by the term "Inflammatory Bowel Disease" (IBD). The other condition that is referred to as an IBD is called Ulcerative Colitis. Both Crohn’s and Ulcerative Colitis are conditions that cause recurring or persistent inflammation in one or more sections of the intestine. The literal definition of "inflammation" is "being set on fire". It is a protective reaction that happens when tissue is injured or destroyed. There are two types of inflammations. The first is acute inflammation, which is defined by heat, redness, pain and swelling. The
especially in the colon. This drug can be used for as long as needed, and it
The principal symptoms of Crohn’s disease are diarrhea and abdominal pain. Other symptoms include abdominal cramping and tenderness (often in lower right area), abdominal distention, fever, fatigue, and rectal bleeding. Bleeding may be serious and persistent, leading to a low red blood cell count or anemia. As the disease progresses, malnutrition, dehydration, electrolyte, imbalances, increased peristalsis, and pain around umbilicus may occur. Another symptom to be
Crohn's disease is an inflammatory bowel disease (IBD). It causes inflammation of the lining of your digestive tract, which can lead to abdominal pain, severe diarrhea and even malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people. The inflammation caused by Crohn's disease often spreads deep into the layers of affected bowel tissue. Like ulcerative colitis, another common IBD, Crohn's disease can be both painful and debilitating, and sometimes may lead to life-threatening complications. Although it may involve any part of the digestive tract from the mouth to the anus, it most commonly affects the last part of the small intestine (ileum) and/or the large
Crohn's disease is a chronic inflammatory bowel disease characterized by an inflammation immune response to tissue that causes redness, swelling and pain of the digestive or gastrointestinal tract.
Crohn 's disease can be both painful and incapacitating, and sometimes may lead to life-threatening complications. If you think you are showing signs of Crohn’s Disease, loss of appetite, weight loss, and feeling of low energy, and fatigue, schedule an appointment with your doctor. Crohn 's disease in children may delay growth and development. Remember, only your doctor can render a diagnosis, so seek medical attention if experiencing any of these symptoms because in more severe cases, Crohn’s can lead to tears in the lining of the anus, which may cause pain and bleeding. Inflammation may also cause a fistula to develop, which is a tunnel that
Treating Crohn’s Disease is directed at interrupting the disease course and relieving clinical symptoms. The gold standard diagnostic tools for Crohn’s Disease is having a dependable image of the mucosal surface through endoscopy like ileocolonoscopy and/ or gastroduodenoscopy. 4 These help provide
When those words, Crohns Disease, came out of his mouth, I did not know what he was talking about. He explained that crohns is inflammation in the digestive system and that it is incurable. My heart dropped to the pit of my stomach. Hearing that I have a chronic was very overwhelming. I never thought this would happen to me. The GI doctor prescribed me more pills to decrease the swelling and to help with the
One is called Crohn’s Disease. It is a chronic inflammatory bowel disease (IBD), caused by overactive immune system, genetics, or the environment, not what you eat. Inflammation may develop anywhere in the body, from the mouth to the anus, but mostly, it develops at the end of the small intestine. About 700,000 of people in the United States have Crohn’s Disease! The symptoms are diarrhea, mouth sores, abdominal pain, reduced appetite, weight loss, etc. Currently, there are no perfect treatment for this disease, but there are some anti-inflammatory drugs, such as oral 5-aminosalycylates, corticosteroids, and immune system suppressors, such as azathioprine, methotrexate,
Inflammatory bowel disease (IBD) can be defined as the chronic condition (it is persistent/ long-standing disease) resulting from inappropriate mucosal immune activation. Inflammatory bowel disease (IBD) can start at any age. However, it is frequently seen among teenagers And also among young adults in their early twenties, both genders can be affected by this disease. There are two conditions that traditionally comprise inflammatory bowel disease (IBD): Ulcerative colitis and crohns disease. Comparison between Ulcerative colitis and crohns disease are clinically useful, because distinguishing between the two conditions allow specialists to choose the right management way. Comparison between Ulcerative colitis and crohns disease are
People who suffer from Crohn’s disease may also suffer the same risks of colon cancer, but typically only if the entire colon is affected. There are also rare extra-intestinal cases of Inflammatory Bowel Disease that occur in organs other that the intestinal tract. These symptoms may include arthritis, liver and kidney disorders, bone loss, and more.