Symptoms And Treatment Of Crohn 's Disease

1421 Words6 Pages
Crohn 's disease is a debilitating inflammatory bowel condition that has the potential to affect any part of the gastrointestinal tract. The disease due to its relapsing and remitting nature decreases a persons quality of life and can lead to complications such as abscesses and fistulae formation, which then require recurrent surgical interventions. The therapeutic endpoint in Crohns disease management is to induce and sustain remission, decrease complications, hospitalisations and surgeries. Therefore, therapeutic management aims to change the natural course of Crohns disease so that people with the condition are not disabled by its relapsing nature. This review whilst establishing the clinical features of Crohns disease aims to investigate the efficacy of these standard therapies. It also attempts to explore alternative approaches to managing Crohns disease that focus on minimising flare-ups and complications. Conventional therapies include antibiotics, glucocorticosteroids, 5-aminosalicylic acids, and to a lesser extent, immunosuppression with azathioprine /6-mercaptopurine or methotrexate. Whilst, these therapies have helped control symptoms the review finds they have made no attempt to modify the disease course. Recently, there have been advancements in treatment, with the introduction of biological agents aiming to combat the ineffectiveness of standard therapy by inducing and maintaining mucosal healing. This review will outline the extend advancements, such as these
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