Symptoms And Treatment Of Inflammatory Bowel Diseases

1805 WordsDec 9, 20148 Pages
In the current world population there is a large increase in people diagnosed with inflammatory bowel diseases (IBDs), lactose intolerance and/or a combination of the two. Theories suggest that the delayed onset of lactose intolerance, in patients who already have IBD’s, may arise as secondary lactose intolerance but only as a byproduct of the IBD. This begs the question of if the prevalence of an IBD predisposes that same person to lactose intolerance and if so, what are the drivers that allow this to happen? Inflammatory bowel diseases are categorized into two subset categories, ulcerative colitis (UC) and Crohn’s disease. IBD’s are defined as a chronic inflammation of all or part of a digestive tract. The inflammation takes place…show more content…
Those who are lactose intolerant also have diminishes levels of lactase, the small intestinal enzyme responsible for the catalysis of lactose. Dietary supplementation of the lactase enzyme has, in some cases, proven to rectify the symptoms of lactose intolerance. During infancy the vast majority of humans have the ability to digest and catabolize lactose into glucose and galactose via the lactase enzyme. This catabolic capability is vital for newborn mammals, given that their primary source of nutrition comes from their mother’s milk. During the weaning period, when children cease to use milk as a primary source of nutrition, the production of the lactase enzyme severely deteriorates and eventually leads to the inability to catabolize lactose. While this may be the natural progression of the expression of the lactase enzyme, there remains a large, predominantly western population that maintains a steady production of lactase, those individuals are known as lactase persistent (Baumgart, et al.). Lactase Persistence- Causes: Lactase persistence has been strongly suggested to be a function of genetic causes and its inheritance occurs in an autosomal recessive manner. Individuals that exhibit the highest lactase activity are genotypically homozygous recessive for lactase persistence; where as individuals who show lower lactase activities are heterozygous or homozygous
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