Symptoms And Treatment Of Lyme Disease

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ntroduction Lyme disease has been the most commonly reported vector-borne illness in the United States since the Centers for Disease Control and Prevention started reporting it in 1991 [1]. It should be noted that Lyme disease does not occur everywhere in the US, and is heavily concentrated in upper Midwest and northeast United States [1]. This report has been compiled to provide recommendations for antimicrobial prophylactic treatment of Lyme disease once a patient encounters a tick bite. Lyme disease is a multisystem inflammatory disorder caused by the spirochete Borrelia burgdorferi, which is transmitted by Ixodes dammini. [3]. I. dammini is commonly known as and referred to as the deer tick. Lyme disease can affect many organ systems…show more content…
Although a vaccine does exist, its cost and multiple doses needed to achieve immunity have limited its acceptability by the medical community [20, 21]. Antimicrobial therapy has been at the forefront of research in trying to identify if prophylactic treatment is necessary, what drug is most successful, and what dosing is most appropriate. Antimicrobial Prophylaxis In 1992 Shapiro et al. published their research informing providers prophylactic antimicrobial treatment is not routinely indicated [2] There were a total of 387 patients in the controlled trial, 203 patients assigned to receive amoxicillin and 182 were given a placebo [2]. Either 250mg of amoxicillin or a placebo was given to subjects three times a day for ten days. 15 subjects dropped out and 7 subjects had already shown positive serologic testing to B. burgdorferi and were therefore dismissed from the study [2]. Out of 173 subjects who received the placebo only two developed symptomatic infection with B. burgdorferi; whereas, none of the 192 subjects who were given amoxicillin showed any infection. They concluded the risk of actually becoming infected with B. burgdorferi is so small that the prophylactic use of antibiotics does not make a clinical significance and should not be used. The authors also indicated that most deer ticks are actually not infected with B. burgdorferi, which
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