Etiology Psoriasis is a common (2% to 3% of the population), benign and life-long chronic inflammatory skin condition involving the skin, scalp, nails and sometimes joints (Mahajan & Handa, 2013). It is genetically transmitted with a 30% increased risk of first-degree relatives developing psoriasis and a 72% concordance between monozygotic twins (Habif, 2010; Mahajan & Handa, 2013). A genetic and hereditary (autosomal dominant with 60% penetration) basis for psoriasis is supported by the presence
PICO Research Question: In patients with moderate-to-severe plaque psoriasis, is brodalumab more effective than ustekinumab, one of the standards of care, in relieving the symptoms of psoriasis? Background: Plaque psoriasis is a painful autoimmune disease that affects up to 3% of the US population.1 Moderate-to-severe psoriasis can have significant psychological and physiological effects on a person’s health and although psoriasis can be controlled, it cannot be cured, so medications play an important
Galen, a Greek physician, was the first to recognize psoriasis as a skin disease and give it its name. Psoriasis comes from the Greek word psora, or “to itch”. It was originally treated with what is basically a “topical arsenic” (Seiden). Psoriasis is a long-term disease that causes skin cells to regenerate too quickly, causing a scale-like rash on the surface of the skin. It is, hereditary and is not contagious. Those who are affected usually have multiple people with the disease in their family
The physician, Galen identified psoriasis as a skin disease through clinical observation. He was the first to call the disease psoriasis. The Greeks has a word for it -psora meaning “to itch”. In 1809, Dr. Robert Willan first recognized psoriasis as a specific clinical entity. Psoriasis is knows as a skin order that forms thick,red, bump patches that are covered with silvery scales. They can appear anywhere on the body,but mostly on the scalp,elbows,knees, and lower back of the body. No one really
Introduction Psoriasis is an autoimmune disease in which the growth rate of skin cells is sped up by a faulty immune system. It is a chronic, and there is no definitive cure for psoriasis. There are many treatments available to control symptoms, and the newest treatments available are biologic drugs. Biologics for Psoriasis work by blocking the actions of T-cells or inhibiting proteins that cause psoriasis symptoms to develop. Biologics are a promising treatment for psoriasis. However, there are
Psoriasis is a genetic disease due to a misstep occurring in the way that a gene works. It is an autoimmune disease, meaning it has an abnormal response to a body part. Psoriasis is an inflammatory skin condition. Color change associated with the plaques is more obvious where there is little scaling of the skin (Psoriasis: The At Your Fingertips Guide, 2005). There are many different forms of psoriasis; this disease can be found just about anywhere on the body. It is also associated with other health
Psoriasis Psoriasis is a chronic skin disorder, easily identified by its symptoms of white, scaly skin and red lesions, though not so easily cured or understood. In psoriasis, skin cells mature faster than the body can shed them, causing a buildup. Although there are many theories as to what the cause of such a disease might be genetics, stress, or other triggers no one is quite sure why the disease occurs, or what could be a possible way to fully cure it. In this essay we will explore
anyone’s eye, but it is a condition known as Psoriasis that affects many individuals. Psoriasis is as the author of the article “Update on Psoriasis and its Management” states, a genetically inherited chronic inflammatory
Psoriasis is a severe skin condition that is found to be very common throughout people. It is a skin condition that is not contagious, where skin cells tend to build up and form scales and dry itchy patches. Psoriasis is a rash that is found on the skin and rarely on the nails and joints. It is also one of the skin diseases that has been around for a long time. The topic of Psoriasis was brought up the bible but it did not go by its name today. For a long time it was called Tzaraat but, it had the
Psoriasis: The Genetic and Immune-Mediated Implications Psoriasis is a common chronic autoimmune disorder that is characterized as having an immune-mediated inflammatory pathology which presents with skin lesions that vary in severity. Affecting nearly 3% of the world population (Jadali & Eslami 2014) the cause of psoriasis in not fully understood, but there is considerable evidence that points to genetic, environmental, and immunological factors that influence the disease.