Synaptic, Redox Control, And Epigenetic Modifications
1151 Words5 Pages
Abstract: Deregulation of cellular energetics is a cancer hallmark associated with tumor cells’ abilities to reprogram the metabolism to support biosynthetic demands of rapidly proliferating cells. This mini review will serve to provide an overview of the biochemical mechanisms involved in deregulated cancer metabolisms and the implications of these activities on signaling, redox control, and epigenetic modifications.
Malignant cancers often exhibit fundamentally altered cellular energetics, conferring advantages to tumor cells by reprogramming the metabolism to support neoplastic proliferation and promote biosynthesis of macromolecules. Deregulated cellular energetics is observed quite widely across a number of human cancers, and is therefore considered a hallmark of cancer. The role of metabolism in cancer has been a topic of interest since the early 1920s when Otto Warburg proposed the Warburg Effect. Under normal conditions, cells metabolize glucose through oxidative phosphorylation and the TCA cycle. However, cancer cells often exhibit increased anaerobic glycolysis. Although glycolysis is less efficient than the TCA cycle and oxidative phosphorylation, it is faster and produces many of the precursor building blocks necessary for the cancer cells to fulfill the metabolic demands of rapidly proliferating cells. Additionally, TCA cycle intermediates are often used in cancer as precursors for macromolecule biosynthesis. Altered energetics can be further observed in