Synthesis, Thermolysis, Novel Semicarbazones And Thiosemicarbazones Derived From 3 Methyl 2 Benzothiazolinone Hydrazone Essay

In the next step, 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-fluorophenyl)acetamide (3a) was subjected to condensation reaction to afford N-(substituted)-2-((6-oxo-5,6-dihydroimidazo[2,1-b][1,3,4]thiadiazol-2-yl)thio)acetamide (4a-m) and their structures were confirmed by spectral analysis. The FT-IR spectrum of compound (4a) showed characteristic absorption bands at 3255cm-1 (NH), 3024cm-1 (ArC-H), 1614 (C=O), 1263cm-1 (C-S) and 1588cm-1, which could be attributed to (C=N). The 400MHz 1H-NMR spectrum of compound (4c), showed a singlet for the amide NH proton at δ 10.37ppm. The signal corresponding to the two protons of NH2 group in the 2-aminothiadiazole ring disappeared and a new sharp singlet for imidazole protons was appeared

Natural products have been a source of medicinal agents for thousands of years. Impressive number of modern drugs derived from natural products. Today, natural products are one of the main interests for research directed towards drug design and discovery. It also has provided considerable value to the pharmaceutical industry over the past half century. In particular, the therapeutic areas of infectious diseases and oncology have benefited much from numerous drug classes derived from natural form and it is used as template for synthetic modification.

INTRODUCTION Hydrazones1-3 were reported to possess various biological activities. In the present communication we report the synthesis of new phenyl hydrazones. These hydrazones were synthesized by using different aromatic aldehydes which react with phenyl hydrazine in presence of alkali to undergo condensation by removal of one mole of water molecule. It is the simplest reaction to form reactive phenyl hydrazones. The synthesized compounds after purification were characterized by spectral methods viz.

In this article, the hydrazones and their substituted species were studied to explore the essential factors influencing on their antimalarial activity. To this aim, we employed quantum theory approach, HF/6-31G* level of theory, and computed the NQCC parameter for all our candidates in this research. NQCC, as a powerful tool, was used here to predict the electronic charge density around the active sites that are susceptible to iron cation chelating.

. Ecologically safe methods for the synthesis of five-membered and six-membered cyclic carbonates by the reaction of transesterification of dialkyl carbonates with dihydric alcohols will be developed.

Three carbon-carbon forming reactions—barbier, wittig, and aldol— were performed in order to analyze which reaction had a more green-chemistry approach. Carbon-carbon bond forming reactions are important in organic synthesis because they allow construction of the desired product. The similarities of these carbon-carbon forming reactions were that they all used a type of aromatic benzaldehyde, which was a reactive, easy to work with organic compound. In contrast, the wittig reaction was solventless, while the barbier and aldol reactions were not. Scheme 1 represents the carbon-carbon forming barbier

Sriram et al. (2011) synthesized 2-(substituted aryl)-N-(substituted) thiazolidine-4-carboxamides. These compounds were synthesized from 2-(substituted aryl)- N-(substituted) thiazolidine-4-carboxamides . 2- (Substituted aryl)-N-(substituted) thiazolidine-4-carboxylic acids synthesized when Potassium acetate was added to a solution of L-cysteine HCl in water. Appropriate aldehyde was added to this mixture. To this mixture, desired primary or secondary amine was added to get required

as our synthesized compounds are thiadiazole and schiff base derivatives i will start with thiadiazole ,A five-membered heterocyclic ring containing one sulfur and two nitrogen atoms.

Benzothiazoles are heterocyclic compounds with multiple application and although they have been known from long ago to be biologically active.1-3 Recently, Racane et al4 have described the synthesis of bis-subsituted amidinobenzothiazoles as potential anti-HIV agents.

The ethyl (3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetate 4C (0.05 mol, 14.37g) was warmed in a mixture of ethanol and DMF (1:2) to get a clear solution and was cooled to room temperature. A solution of KOH (0.08 mol, 4.81g) in water (10 ml) was added to this solution and the mixture was stirred for 24h at room temperature to ensure the completion of the reaction. The completion of the reaction was monitored by TLC (CHCl3:MeOH, 9:1). The reaction mixture was evaporated to dryness and the residue dissolved again by adding ice cold water. The insoluble impurities were separated by filtration and the filtrate was acidified with 4N HCl to get a solid product (3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetic acid (4D), collected by filtration.

CCCP, carbonyl cyanide m-chlorophenyl hydrazone, is a potent uncoupler of electron transfer from ATP synthesis by blocking formation of the electrochemical proton gradient generated during electron transport by the respiratory chain carriers. This disruption of the photosystem assembly in cyanobacterium Synechocystis 6803 has been used as a strategy for the accumulation of distinct transient assembly intermediates. This has provided a critical test of the possibility that partially assembled complexes can be isolated from the CCCP-treated cells in a form in which transient associations with participating assembly factors are retained. In our experiment, Rba. sphaeroides will be used which consists of rows of reaction center-light- harvesting

Abstract: Synthesis of new compounds 2-(bis((1H-benzo[d]imidazol-2- yl)methylthio)methyl)-1H-benzo[d]imidazole (6a) and 2-((((1H-benzo[d]imidazol-2-yl)(((5- hydroxy-1H-benzo[d]imidazol-2-yl)methyl)sulfanyl)methyl)sulfanyl)methyl)-3H- benzo[d]imidazol-5-ol (6b) were carried out under two different reaction conditions, namely the conventional method and microwave irradiation conditions. The compounds (3a,b), (5a,b) and (6a,b) were synthesized by using microwave methods which showed decrease in the reaction time and increasing in the yield as shown in Table (1). The structures of the synthesized compounds were confirmed by IR; NMR and elemental analysis. The antimicrobial activityof the synthesized benzimidazolemethanethiol derivatives

To overcome this issue, many Azone-like compounds have been synthesized (55). Modification in the structure of Azone includes change in:

Isoniazid was identified by pursuing derivatives of nicotinamide. Optimization of nicotinamide produces two distinct drugs with very different charactetistics, rifampin and pyrazinamide. There are two independent tracks of SARs for this drug series, one governing the activation of the prodrug and another governing the interaction of the active species with InhA. Many groups at the 4-position can be activated inside M.tubeculosis, and are possible prodrug structures. After activation, the structural requirments for InhA binding appear to be very stringent. Only the isonicotinoyl core structure is substantially active among many aryl and heteroaryl groups explored. The isonicotinoyl group could be substituted with lower alkyl groups while

In this experiment, benzopinacol is to be synthesized through photochemical reaction from benzophenone and benzopinacolone via acid-catalyzed rearrangement of benzopinacol.