Synthesis of Acetaminophen Essay

1231 Words Feb 27th, 2013 5 Pages
Synthesis of Acetaminophen
Lab Report

Bijal Patel, 20467049
Partner: Poojan Parikh
T.A.’s: Long Pu
CHEM 123L, Section: 006, Rm: ESC 149
Tuesday February 4, 2013, 2:30pm-5:20pm
Experiment Done: Tuesday January 22, 2013

Introduction

Acetaminophen was first introduced in 1955 (Richman, 2004). It is an over-the-counter drug that relieves pain and reduced fevers. Acetaminophen is considered an alternate to aspirin since it does not irritate the stomach (Richman, 2004). It also has very low toxicity is it is used properly. Acetaminophen is cheap and easily obtainable from any pharmacy.
Acetaminophen is created when the amine group of p-aminophenol is acetylated by acetic anhydride. This creates an amide functional group and the
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There were very few, if any, errors made during this lab.

Questions

1. a) If 20 mL of water were added for every 1g of crude product then crystallization would occur in less quantity or not occur at all. As the solution is dissolved, heated, and later cooled, the impurities of the solution remain in the solution. As more solvent is added, more of the product will remain in the solution rather than crystallizing; hence, a much lower yield would be obtained.

b) If 5mL of water were added for every 1g of crude product then one of two things would happen; the solid would not dissolve or the impurities would still be present within the product. The solvent is used to dissolve all the impurities of the crude product and if less solvent is available, the impurities would remain within the product.

c) If room temperature solvent was used rather than cold solvent then more of the product will remain in the solution. As temperature increases, solubility also increases in most cases, which would keep some of the product dissolved resulting in a lower yield.

2. a) An organic compound is any compound that contains carbon, generally, are large chains of carbon that are covalently bonded. They can be gaseous, liquid or a solid (Seager; Slabaug, 2004).

b) An amine is an organic compound/functional group that is derived by replacing one or more of its hydrogen atoms in ammonia
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