Systematic Lupus Research Paper

Lupus is a chronic inflammatory disease of unknown cause that can affect virtually any part of the body. The medical term for Lupus is Systemic Lupus Erythematosus or better known as SLE. With Lupus there is a malfunction in some of the cells of the immune system. "In Lupus, the body overreacts to an unknown stimulus and makes to many antibodies, or proteins directed against body tissue. Thus, Lupus is called an autoimmune disease. ”#

The exact cause for Lupus is unknown; however experts believe that some people are born with certain genes that affect how your immune system works. It appears that people with inherited predisposition for Lupus may develop this disease when they come in contact with “triggers.” Some potential triggers are: sunlight, infections, and medications. Sunlight exposure can lead to Lupus skin lesions, or trigger and internal response in susceptible people. Having an infection can initiate Lupus, or causes a relapse in symptoms. Also some anti-seizure, blood pressure, and antibiotic medications can trigger Lupus. People who have drug induced Lupus noticed their symptoms go away once they stopped taking the

The American College of Rheumatology (ACR) and the Georgia Council on Lupus Education and Awareness (GCLEA) partnered to increase community awareness on Systemic Lupus Erythematosus (SLE) and to further educate lupus patients throughout the underserved region of southwest Georgia. Systemic Lupus Erythematosus, the most common form of lupus, is an autoimmune disease that causes the immune system to attack needed body tissues (“Lupus,” 2018). This specific type of lupus affects major functions of the body including the brain, lungs, skin, and kidneys. Lupus is commonly difficult to diagnose in humans due to its vague symptoms that mimic the symptoms of other major conditions (‘Lupus,” 2017). Presently, researchers are unaware of the origins

Systemic Lupus Erythematosus (SLE) is an autoimmune disease. The cause of the disease is unknown is still unknown today. Some researchers would lean it being caused by genetics being, that it mostly effects Asians and African Americans and is more prevalent in women than in men. Systemic Lupus Erythematosus disease causes the body's immune system to attack the healthy tissues accidently. It can affect the joints, skin, kidneys, brain, and other organs. Although, certain drugs can cause Systemic Lupus Erythematosus. Systemic Lupus Erythematosus can unknowingly happen at any age. Studies show that it appears mostly between the ages of 15-44. In the United States the reported prevalence of SLE is 20 to 150 cases per 100,000.

Lupus is a chronic, lasts for a long time, inflammatory and autoimmune disease. Lupus is characterized by being autoimmune which is caused by antibodies made by the immune system that attacks the body and its tissues. Also, Lupus is a systemic disease. Systemic diseases in medicine mean:"affecting the whole body, or at least multiple organ systems."(1) Moreover, this diseases has a unique characteristic of flare-ups or relapses, when the disease shows severe symptoms, and remissions when the disease gets better and shows mild or no symptoms at all.(2)

Treatments: Fortunately Lupus has a variety of medication ranging from minimum to maximum strength. Usually Lupus medication change during a person’s lifetime. However with Lupus it can take Doctors months or sometimes years to find the perfect medication to keep the disease under control. The FDA unfortunately have only approved few medications which are Corticosteroids, Antimalarial, and Aspirin.

Inflammation of the Kidneys is one of the most serious symptoms of Lupus. When the Kidney are not working properly they leak protein and is eliminated through urination with the lack of protein causes fluid retention and causes swelling or Edema in the lower extremities. This symptom is one of the first signs of lupus nephritis. Lupus affects the kidney functions to remove waste products and excess fluids from the body. A biopsy is used to determine the extent and severity of kidney disease. The tissue gathered is then examined through a microscope to determine inflammation and scarring. Once all the factors are gathered such as amount of protein in the urine, reduction of kidney function, and the Biopsy of the kidney drug therapy may be used to control inflammation and suppress the activity of the immune system. Although high dose of medications may have many side effects when used at high does it is needed to get the inflammation under control and then can be tapered down to a low does with lower side

Lupus is a chronic, autoimmune disease that can damage any part of the body. The skin, joints, or organs inside the body can be affected by this. Chronic means that the symptoms tend to last weeks and sometimes for many years. With lupus, the immune system makes autoantibodies instead of creating antibodies, which protect the body from bacteria and viruses. Autoantibodies do more work than antibodies by attacking the viruses as well as healthy tissue. When this happens inflammation, pain, and damage occurs to many parts of the body. Lupus is not a contagious disease that people should be afraid of. With some people, no visual changes happen, which means it is not noticeable to see someone with Lupus ("What is lupus?", 2016).

Lupus is an autoimmune disease in an overly active state that attacks healthy, functioning tissue. This disease is not well known mainly for two reasons, firstly, it is not given enough hype in social media. Secondly, many people show symptoms during the early stages of lupus however, the victims do not recognize its severity until the disease has afflicted permanent damage. This is usually because some symptoms are similar to other less threatening ailments. Lupus affects many systems of the body which include the gastrointestinal system, the cardiopulmonary system, the musculoskeletal system, the renal system, and the integumentary system. This disease is formerly caused by genetic inheritance however, there are a great number of factors that trigger the immediate onset of lupus, as it is not necessarily prevalent on a person who has the genes from birth. Although there is no known cure for lupus, efficacious forms of treatment are possible.

If you or your loved one has recently been diagnosed with having lupus, the main thing that you need to concentrate on is reducing the inflammation and also managing the different symptoms that come with the disease. This is essential, because lupus can dramatically affect your life, and maintaining a balance is necessary to avoid suffering from bouts of depression, panic attacks and that constant haunting fear.

Systematic lupus Erythematous (SLE or Lupus) can affect any organ in the body and may cause a wide range of symptoms. SLE symptoms can vary from person to person and can change over time. Lupus affects 1.5 million Americans and millions more worldwide lupus.org (N.d) 2016. The cause of lupus is unknown some research have found genetics and hormones are to play a role. The majorities of people with lupus 90% are female, and they seemed to develop signs and symptoms of the illness between the ages of 15 and 44 (2016). Children are affected with lupus. Approximately 5,000 to 10,000 of the million Americans with lupus are diagnosed while under the age of 18 (2016).African American women are three times more likely than Caucasian women to get lupus

Systemic Lupus Erythematosus, or Erythematous, also known as SLE, is a chronic inflammatory, autoimmune disease that transpires when the body’s own immune system assaults, with “variable manifestations”, it’s own tissues and organ systems throughout the itself1,2,3. This can also include joints, heart, lungs, skin, brain, blood cells, etc1. Systemic Lupus Erythematosus is known to have an impact on the organ network involved with immune complexes and multiple antibodies, especially antinuclear antibodies, or ANAs, an abnormal antibody that is targeted to cause certain edemas throughout the body and different tissues4.

Lupus also known as Lupus Erythematosus is a long standing autoimmune disease. In an autoimmune disease the body immune system attacks itself. The inflammation that has develop by these attacks causes damage to the bodies tissue and organ. The frequently affected bodies tissue and organ are the brain, joints, skin, kidney, heart, lung, and blood vessel. Nevertheless, this disease is difficult to assess due to the widespread of affected age groups, ethnics, gender geography area and socioeconomic differences researcher and scientists cannot determine its origin. There is different form of lupus and the most common is SLE or systemic Lupus Erythematosus which affect many parts of the body, Discoid lupus erythematosus that causes skin rashes that doesn’t go away, Subacute cutaneous lupus erythematosus causes skin sores on parts of the body that are exposed to sun, Drug

Systemic Lupus Erythematosus is complex autoimmune disease caused by a combination of genetic, epigenetic, and environmental factors. The body’s autoimmune cells fail to distinguish a diseased cell or foreign organism from its own healthy cells. Consequently, the autoimmune system attacks its own cells, causing inflammation in multiple systems including; the kidneys, skin, heart, lungs, hematopoetic, and nervous system.

As with all other areas involved with lupus treatment is also multi-faceted. Because of the ability of the disease to damage so many areas of the body it is often a multitude of different medicines used to suppress “flare ups” and decrease damage to affected areas. Some of these medicines include Nonsteroidal anti-inflammatory drugs (NSAID) for joint and chest pain and inflammation. Corticosteroids (natural anti-inflammatory hormone) rapidly suppress inflammation which can be applied orally, topically, or intravenously, because corticosteroids are so potent doctors often seek lowest required dose for desired benefit. Immunosuppressives are used for patients whose kidneys and central nervous system are affected by lupus. Immunosuppressives restrain the overactive immune system by blocking the production of immune cells, these drugs can be given orally or intravenously.