Systemic Lupus Erythematosus ( Sle )

     Lupus is a potentially life threatening disease that effects about 1.5 million Americans. Lupus can effect many different parts of the body. Lupus is a type of autoimmune system disorder in which the body cannot distinguish the difference between foreign antibodies and its own organs. So basically what happens is that the body ends up attacking its own organs thinking they are foreign substances. (The Lupus Foundation of America)

Research suggests that there is a genetic component that predisposes some people to lupus, but it seems it has to be triggered by another event (Mayo Clinic). Lupus is thought to have three different possible triggers, though research into understanding them is ongoing. Sunlight may trigger skin lesions caused by the autoimmune response of lupus. And infections and medications that affect the immune system can also trigger a symptom outbreak (Mayo Clinic).

The following search mechanism was used: (“lupus, African Americans” [MeSH Terms] OR (“lupus” [All Fields] AND “African Americans” [All Fields]) OR (“lupus, blacks” [MeSH Terms] OR (“lupus” [All Fields] AND “blacks” [All Fields]) OR (“lupus, minorities” [MeSH Terms] OR (“lupus” [All Fields] AND “minorities” [All Fields]) OR (“SLE, African Americans” [MeSH Terms] OR (“SLE” [All Fields] AND “African Americans” [All Fields]) OR (“SLE, blacks” [MeSH Terms] OR (“SLE” [All Fields] AND “blacks” [All Fields]) OR (“SLE, minorities” [MeSH Terms] OR (“SLE” [All Fields] AND “minorities” [All Fields]) OR (“lupus, race” [MeSH Terms] OR (“lupus” [All Fields] AND “race” [All Fields]) OR (“SLE, race” [MeSH Terms] OR (“SLE” [All Fields] AND “race” [All Fields]). A total of 344 results were obtained and the title and abstract were reviewed by two of the authors (EMW and LB). The inclusion criteria were original research papers related to the prevalence and clinical course of SLE in African Americans. We excluded literature reviews, case reports, and surgical techniques articles. We also excluded papers published before 2000. In addition, a manual search of all referenced articles not found in the main search was performed. A total of 71 full papers were full reviewed, but we also excluded 38 additional papers because they were case studies or not limited to African Americans, for a total of 33 studies included

Etiology: SLE is a combination of genetic and your environment. It is known when the disease is inherited it can be triggered when coming in contact with the environment. However the cause of lupus in most cases

An autoimmune disease that causes the body to attack its own healthy cells, lupus has no known origin. While its symptoms are primarily recognizable, they can often mimic other diseases, thereby delaying accurate diagnosis. Joint pain, poor circulation and a telltale rash are just three of myriad symptoms indicative of lupus, a disease that inevitably impacts major organs by way of compromising the body's defenses, as well as through invasive steroid treatment that weakens bones.

Makover, M. & Zieve, D. (2011, February 14). Systemic Lupus Erythematosus. National Center for Biotechnology Information. Retrieved July

The cause of Lupus is still an enigma, and this is one chronic condition that still can’t be easily defined.

This will be the main form of lupus that will be talked about and how it affects the kidneys."With (SLE) the dieseas can affect the "kidneys, brain or central nervous system,blood and blood vessels,skin ,lungs ,heart and

The following are the clinical features which are can be considered as a warning of impending flare:

Systemic Lupus Erythematosus (SLE) is an autoimmune disease. Consequently, all organs and tissues are at risk of being damaged by inflammation. The most affected organs are the kidneys, lungs, heart, and skin (Harvery and Zieve; Simanta, and Mohan). The most affected tissues are the joints, and nervous tissues. The renal system controls blood pressure and blood volume. It also removes waste products and toxins from the blood. SLE causes inflammation of the nephrons, preventing the kidney to properly maintain blood volume and properly filter waste products and toxins (Harvery and Zieve). Kidney inflammation alone will trigger complications throughout the entire body. The lungs are responsible for the gas exchange with the

Lupus nephrirtis is more commonly known as “lupus” is an inflammation of kidney caused by Systemic lupus erythematosus (SLE) , Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the loss of immune tolerance to nuclear self-antigens. The deposition of autoantibodies along the glomerular basement membrane results in immune complex-mediated glomerulonephritis generally characterized by like malar rash, discoid rash, photosensitivity, oral ulcers, nonerosive arthritis, pleuropericarditis, renal disease, neurological manifestations, and haematological disorders.

Lupus Erythematosus, or Lupus, is a chronic autoimmune disease that causes the human body to attack itself. Autoimmune (meaning “self” immune) diseases result in the body being unable to distinguish between foreign threats and the body’s healthy tissues. Lupus has the potential to range from a mild aesthetic inconvenience to a life-threatening ailment. There is believed to be about five million people worldwide who are living with a form of Lupus (Ginzler & Tayar, 2015). While being a disease that transcends time, gender, age and ethnicity, significant medical progress was not made until the mid 20th century.

Systemic Lupus Erythematosus (SLE) is a genetic disorder. SLE is a type III hypersensitivity or an autoimmune hypersensitivity (VanMeter, K. C., PhD, & Hubert, R. J., BS, 2014). Meaning that the body is attacking itself. In SLE a large number of autoantibodies circulate through the body (VanMeter, K. C., PhD, & Hubert, R. J., BS, 2014). These autoantibodies are deposited into the connective tissue all over the body (VanMeter, K. C., PhD, & Hubert, R. J., BS, 2014). These autoantibodies activate the complement system and cause inflammation and necrosis of the tissue that the autoantibodies are near (VanMeter, K. C., PhD, & Hubert, R. J., BS, 2014). This usually takes place in many systems in the body. In order to be diagnosed at least four body systems have to be affected.

sTM which is normally a component of vascular EC membrane easily released to plasma in patients with active SLE due to persisting EC detachment in active SLE patients. It was suggested that elevated sTM levels reflect EC damage rather than activation, because EC–leucocyte adhesion and interaction after the activation of inflammatory cytokines might result in the release of TM from the EC surface (Fiedler and Augustin,

Systemic Lupus Erythematosus is a chronic autoimmune disease which causes inflammation of your joints, tissues, and organs. The inflammation presents itself as heat, pain, swelling and redness. SLE is a variable disease that doesn’t take any one particular course; therefore its unpredictability makes it even more devastating. No two people will experience the same disease symptoms or severity level. As S.L.E progresses there will be periods of very subtle to no symptoms at all called remission or an exacerbation of symptoms called flares.