T2DM ( Type 2 Diabetes Mellitus : A Study

Bckground While modern lifestyles and medical care have certainly improved the longevity of humans in the developed world, and contributed to a greater quality of life scenario, those same lifestyles have engendered a number of issues that contribute to disease. Lack of proper diet, fast food, high fat and carbohydrate diets without adequate fruits and vegetables, lack of exercise, smoking and alcohol contribute to an epidemic of obesity which, in turn, contributes to a serious metabolic disorder called Diabetes Mellitus Type 2. While not managed by insulin injections, it is nevertheless quite serious and has a number of progressing symptoms that, if not treated properly, can result in cardiovascular, renal and neurological problems, as well as amputation, ocular issues, and even cognitive dysfunction.

Type 2 diabetes (formerly called non-insulin-dependent diabetes (NIDDM), obesity related diabetes, or adult-onset diabetes) is a metabolic disorder that is primarily characterized by insulin resistance, relative insulin deficiency, and hyperglycemia.

Your written answers to the questions below are to be available to be sighted by your lecturer (not submitted to the School Office) at the start of the tutorial session. To be recorded as attending the tutorial requires that the lecturer deems that the worksheet has been satisfactorily attempted.

The mapping of human genes has allowed for certain genetic disorders to be identified according to the genes that it is affecting. This has created a map that other individuals' genes can be compared to in order to determine any mistakes or any alterations that may lead to the development of a disease. Any changes in epigenetic

Diabetes Mellitus is the metabolic disorder characterized by high levels of blood glucose that is caused by deficiency of production of insulin, action of insulin, or may be both of them. The uncontrollable output of hepatic glucose and reduced uptake of glucose by the skeletal muscle with reduced synthesis of glycogen lead to hyperglycaemia. Diabetes is a complicated disease; it can affect mostly every organ of our body and causes devastating consequences.

Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.

indicate that inherited genetic variation is an important risk factor for obesity. It was also pointed

It may be possible to pass down epigenetic changes to future generations if the changes occur in sperm or egg cells. Most epigenetic changes that occur in sperm and egg cells get erased when the two combine to form a fertilized egg in a process called "reprogramming." This reprogramming allows the cells of the fetus to "start from scratch" and make their own epigenetic changes. However, scientists think that some of the epigenetic changes in parents ' sperm and egg cells may avoid the reprogramming process and make it through to the next generation. If this is true, things like the food a person eats before they conceive could affect their future child. Scientists now think epigenetics can play a role in the development of some cancers. For instance, an epigenetic change that silences a tumor suppressor gene, such as a gene that keeps the growth of the cell in check, could lead to uncontrolled cellular growth. Another example might be an epigenetic change that "turns off" genes that help repair damaged DNA, leading to an increase in DNA damage, which in turn, increases cancer risk. (US, National Institutes of Health)

Genetics is a field of science that has long been studied, but researchers and scientists have discovered a new branch that changes the way genetics and evolution has been looked at before. Deepak Chopra and Rudolph E. Tanzi skillfully describe this new subject in their book Super Genes. The book includes information on the history and discoveries of epigenetics, the changes the readers can make to unlock and harness the power of their genes, and the research and experiments that prove the benefits of those changes. Ultimately, the purpose of Super Genes is to inform the readers that they can control their own genes, despite preceding understandings of biological destinies, by making favorable lifestyle choices that leans towards the state of optimum health and well being.

Obesity in the United States has now become the number one cause of preventable death in our county and for the first time in the history of the world obesity has claimed more lives than malnutrition. Within the past 20 years we have seen a dramatic increase in diseases that are related to obesity and the most disturbing is Type II Diabetes in the adolescent population. Adolescent Type II Diabetes was unheard of before 1980 but within the last 20 years our country has witnessed a frightening change in this statistic.

Type II Diabetes Mellitus (DM) is a chronic disease that influences the physical and social aspects of life for millions of people living in New York City (NYC). The excess accumulation of glucose in the blood caused by this disease can lead to the breakdown of many organs in the human body leading to increased hospitalizations and mortality. Although diabetes is a manageable disease given the appropriate care and education, the disease and its complications disproportionately affect African-Americans or non-Hispanic blacks then any other ethnic group in NYC. The NYC Department of Health & Mental Hygiene (DOHMH) reports death rates among black New Yorkers are higher than among whites, regardless of neighborhood income. There is a significant number of non-Hispanic blacks afflicted in low-income neighborhoods due to the environmental injustices such as lack of fresh food options, neighborhood poverty, and limited recreational space for physical activity and exercise. With lifestyle modification as the mainstay of treatment, recognizing the environmental deficiencies and rectifying these problems at the local and federal levels will help to decrease this health disparity.

The purpose of the paper was looking at the quality of life of diabetic patients. Type two diabetics that have a support system compared to those that don’t have a support system have an improved quality of life after being diagnosed. The level of evidence of this study was a cross sectional study. Researching the article was done by going to the Clarkson College website, then going to the student life tab and choosing library. Clicking on the “C” on the article database and clicking on the CINAHL Complete link. Typed in diabetes mellitus in the first box, then where it has the first and changed selection to not, then in the second box typed out systematic review. Then scrolled down to where

Not only do the foods consumed during pregnancy alter the epigenetic marks of offspring, significant evidence is showing that those epigenetic marks can have transgenerational effects (Heard & Martienssen, 2014). One recent study showed that children of obese fathers were at a higher risk of developing obesity themselves. The epigenetic marks of lean and obese men showed similar

There were several family members with the diagnosis of obesity. However, it seems that initially it may have been environmental factors which influenced susceptibility for obesity and later generations. This revelation was discovered by tracing the genes of JT Sr’s parents and MM’s parents. There was no genetic link to obesity until JT Sr. and MM. Research was extended to the grandparents of JT Sr. and MM with no trace of obesity.

Epigenetics can be hereditable or environmental factors that affect the expression of genes and lead to changes in gene expression. Unlike genetics, epigenetics does not only have to do with which genes are passed down to the offspring and the DNA sequence. The environmental conditions of the offspring’s parents impact the genes in their eggs and sperms by “switching on” certain genes and “switching of” others (Dowshen). Since the genes expression of the gametes are affect, the phenotypes of the offspring will change. Even in a person’s lifetime, environmental factors such as stress, chemical exposure, and diet can continue to impact gene expression through DNA methylation. During DNA methylation, a methyl group is randomly added to a 5-carbon cytosine ring, making 5-methylcytosine and these groups inhibit transcription. (Cheriyedath). Due the fact that transcription is not possible, the expressing of the genes in that section of the DNA strand will be suppressed. The attachment of the methyl group to DNA is not determined, which means that