TE-5 Essay

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In this study, TE-5 doses of 0.04, 0.4, 0.12, and 4 ml/kg (a dose calculated to be appropriate for a subject, 10 times the appropriate dose, 30 times the appropriate dose, and 100 times the appropriate dose) were administered to rats in order to examine the effects on the elemental levels and blood properties of the living organisms, and to evaluate the safety of TE-5 doses with regards to an organism’s homeostasis. First off, iron is excreted from the body mainly via bile and the intestinal absorption system. (12) In this experiment, even in very low TE-5 dose groups, remarkable changes in the iron content of tissue was not observed, which can probably be blamed on iron excretion via bile corresponding to the dosage of TE-5 which…show more content…
On the other hand, extracorporeal excretion of zinc is mainly carried out via pancreatic liquid as is known to play a role in the homeostasis of zinc in the body. In this experiment, rapid changes in zinc content in the tissue were not observed, even in the dose groups up to 1.2 ml / kg. This suggests that pancreatic fluid effectively excreted zinc when the dose of TE-5 was 1.2 ml / kg or lower. The liver plays a central role in copper homeostasis and can be said to be the most important organ involved in storage, blood transport, protein ceruloplasmin production, and bile duct excretion. (17, 18, 19) Also, in this experiment, no significant increase in the copper content in the liver was observed, even in the 1.2 dose group (30 times adult regular dose) This is because copper is excreted in the bile duct and does not get reabsorbed like iron. Excreted copper does not return to the liver. Also, in the 4 dose group (100 times the adult regular dose) a marked rise in copper content was observed in the liver, spleen, kidney, and tibia, probably because at this dose, copper homeostasis failed. Manganese has a low toxicity (12), but chronic manganese poisoning is often reported, such as with people with Parkinson’s or other central nervous diseases. Manganese mine workers are especially susceptible to this. (20, 21)The main excretion route of manganese is the excretion of feces. (22) In
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