Tablets Of Hydrochlorothiazide Using Natural Disintegrants

Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, “hard” and “soft”. The hard capsule is also called “two piece” as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the “cap” which fits over the open end of the longer piece, called the “body”. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard

Dosages of the drug vary from one extreme to another based upon the patients needs.

In an emergency situation, why is a drug most commonly delivered via injection versus an oral route?

The majority of medicines are formulated for oral administration. This means they are taken via the mouth, in the form of a tablet, capsule, liquid or suspension. These medicines come in a variety of

This is medication that is taken via the mouth. This can be in the form of tablets and capsules. If an individual finds it difficult to swallow tablets oral medication is also available in liquids, suspensions and syrups. Sublingual medications are for example when tablets are placed under the tongue to dissolve quickly.

The antacid tablets were not crushed properly, resulting in big crumbs of the tablet which will affect the dissolving process of the lab.

Oral - medicines can be given orally in the form of capsules, tablets, liquids or powders.

Theophylline is a bronchodilator used in the treatment of asthma, it has a low molecular weight of 180.2. It is slightly acidic, when in a saturated solution of water and has a pKa of 8.81.

Absorption – “How the drugs enter the circulation process through the body, and how they resist general breakdown by the stomach, liver, and the intestines”. Some of the factors that affect the absorption of drugs in the body is as follows, “acidity of the stomach, Physiochemical properties, Presence of food in the stomach or intestine, and Routes of administration”,

Pharmacokinetics "is the way a drug is absorbed, distribution, metabolism, and excretion (pg. 749 Treas)

The hypothesis was formed under the thought that the fastest dissolving pill would be the most effective because the sooner the ingredients and materials were realized, the sooner they would be able to attack and neutralize the pain, therefore getting the job done quicker or more efficiently. The hypothesis was not supported because, overall, the first two pills to dissolve were both children’s pain killers and were “junior strength”. Therefore, these medicines could not have been the most effective because the strength is significantly weakened to accommodate to young kids, and would not be as effective as normal strength medicines. In order to accurately determine the time taken for the pills to dissolve inside the body, it is very important to create a solution similar to stomach acid. Stomach acid was simulated by heating vinegar, which has the same ph level of stomach acid and shares other similarities in makeup and properties. The vinegar was heated to 36.7 degrees Celsius and constantly stirred to represent the temperature and motion of stomach acid. Eight different pills were timed to see how fast they dissolved. Each type of pill was tested three times in order to find an average for each medicine. The pills tested were Advil, Children’s Advil Grape Flavored, Ibuprofen, Children's Ibuprofen Grape Flavored, Tylenol, Tylenol Liquid Gels, Aleve, and Aleve Liquid Gels. The children's strength pills were the first two medicines to dissolve. Aleve was the slowest to dissolve and took almost two hours to dissolve. The liquid gel capsules were the second and third slowest pills to dissolve. In order, from fastest to slowest to dissolve, the medicines were Children's Ibuprofen Grape Flavored, Children’s Advil

Research indicates that small molecules are the most common and more easier form of drug therapeutics. Small molecules are easier and more cost effective to produce. However because they are chemically produced and are ingested through tablets, it makes it difficult for them to have a lasting affect within the body. Researchers are looking into using biologics as an alternative form of therapeutic for certain diseases. Biologics are naturally synthesised from various sources. It has been known that biologics would have a longer “life expectancy” within the body because it would be given intravenously, directly into the blood stream avoiding it from being broken down by the G1 tract which would occur with a small molecule (Bayer HealthCare,

One of them is medication compounding; that is to prepare the drug in a particular dosage form to

The major action of thiazide is to inhibit sodium chloride transport in the early segment of the distal convoluted tubule. Thiazide are orally administrated and activated, their duration of action is of 6 to 12 hours (Katzung & Trevor, 2015).

The mucilage of this plant has disintegrating properties, it contains L-rhamnose, D-galactose, D-galactouronic acid, and D-glucuronic acid [6,28]. Shah and Patel prepared acelofenac ODT by DC using 6% of this disintegrant, the disintegration time was found to be 20 seconds. The results of Swelling Ratio (SR) , angle of repose, bulk density and compressibility index were observed as 9, 26.5oC, 0.65g/cc and 16% respectively [40] which indicates excellent flow and good compressibility according to European pharmacopeia classification [41].