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Taking a Look at Dextromethorphan

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Antitussive drugs are one of the most extended formulations category in the world that use for supperessing cough and cold, for treating the symptoms of a cold or influenza and relief of cough(Allen and Popovich 2005)(Allen and Popovich 2005). Dextromethorphan (DXM).scheme 1.(o-3-methoxy- N-methylmorphinan) is a one of the older and popular antitussive drugs that used to treat the cold symptoms that effects centrally at the cough center to raise the threshold for coughing (Goodman 1990, Dale)(Goodman 1990, Dale)(Dale) DXM is also combined with other active ingredients like chloropheniramine and it could abuse or misuse for numbing and hallucinogenic such as LSD. (McFee, Mofenson, and Caraccio 2000, Mendelson 2001) (McFee, Mofenson, and Caraccio 2000, Mendelson 2001). therefore there is more concern about DXM determination in pharmaceutical dosage form. developing sensitive, simple, and rapid method for determination of DXM has been become an important target in control pharmaceutical dosage form.

Therefore wide range of analytical methods for quantitation of DXM have been developed such as, high performance liquid Chromatography(HPLC) (Abdel-Moety, Al-Deeb, and Khattab 1995, Tedesco et al. 2013, Eichhold et al. 1997, Hoskins, Shenfield, and Gross 1997) (Abdel-Moety, Al-Deeb, and Khattab 1995, Tedesco et al. 2013, Eichhold et al. 1997, Hoskins, Shenfield, and Gross 1997) 7), thin-layer Chromatography(Singh and Moody 1995)(Singh and Moody 1995) ultra violet(UV)
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