Taking a Look at Systemic Sclerosis

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Systemic sclerosis, also known as, scleroderma or CREST syndrome is a chronic inflammatory, autoimmune connective tissue disease. Scleroderma is a connective tissue disease that involves changes in the skin, blood vessels, muscles, and internal organs. This disease can be classified into two main types, systemic or localized. Systemic scleroderma can affect all parts of the body, such as internal organs, skin, and blood vessels. Localized only affects the skin and is not life threatening, as systemic can be. Scleroderma can be progressive and it involves the skin and connective tissues that tighten and harden. It is a type of autoimmune condition that occurs when the immune system misguidedly attacks and destroys healthy body tissue.
Autoimmune diseases, there are cell-mediated immune responses against parts of the body’s own tissues. Many times autoimmune diseases are referred to “body snatchers”. The progressive nonconformity of extra cellular matrix deposition, cutaneous and multi-organ visceral fibrosis, alternations in microvasculature like small arteries and vessels, and body fluid immunological abnormalities are characteristics of progressive systemic sclerosis. Connective tissue involvement of the lungs, skin, heart, kidneys, intestinal tract, muscles, and joints are affected with progressive systemic sclerosis, but not localized scleroderma. This tightening can become nonfunctional for daily activities. Numerous infectious agents (bacterial and viral) have been

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