Taking a Look at Toxoplasma Gondii

1127 Words Feb 2nd, 2018 5 Pages
It has a facultative heteroxenous life cycle and it can infect all warm-blooded animal including mammals, birds and humans. T. gondii is prevalent in most countries of the world and is of medical importance, because it may cause abortion or congenital disease in its intermediate hosts (Tenter et al. 2000). In its intermediate host, T. gondii undergoes two phases of asexual development. During the first phase tachyzoites multiply in different types of host cells. The last generations of tachyzoites initiate the second phase of development, which results in the formation of cysts in the intermediate host. Within the cyst, bradyzoites multiply rapidly and these cysts readily form in the neural and muscular tissues of the host. However, they may also be found in visceral organs such as the lungs and liver( Tenter et al. 2000). These cysts are immediately infectious to the intermediate host. In many intermediate hosts the cysts may persist for the life of the host giving rise to a latent infection. If the cysts are ingested by a definitive host, the bradyzoites initiate another asexual phase, which consists of repeated endopolygeny in epithelial cells of the small intestine (Tenter et al. 2000). Then comes the sexual phase of the lifecycle. Oocyst formation takes place in the epithelium of the small intestine and unsporulated oocysts are released into the intestine and passed out with defecation. Sporogony…

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