Taking a Look at the Power of Heroin

605 WordsJan 29, 20182 Pages
Heroin is a powerful synthetic opium drug that falls into the schedule 1 drug category. Heroin can be administered though injections (Intramuscular, Intravenously), inhalation (smoked), and the mucus membrane (snorting/sniffing). It is believed that Heroin is three times more potent than morphine; which it is synthesized off of. This is due to the two acetyl groups that added on to the morphine to produce diacetylmorphine, or what is known as heroin today. Heroin it mimics endogenous opioids that are found and produced naturally in the human body (dynorphins, enkephalins, endorphins, endomorphins and nociceptin) just like morphine and the other opium drugs. Once it mimics a natural opioid, like endorphins, it can bind to the opioid receptors that are located throughout the body. Heroin affects all of the opioid receptors (kappa, mu, and delta) but mostly affects the mu opioid receptors which are the strongest receptors that deal with analgesia, and euphoria. The Mu receptors are located in brain (amygdala, medulla, thalamus), spinal cord, and peripheral nervous system; which explains Heroin’s effects on the human body. When Heroin is administered orally it goes through 1st pass metabolism in the liver and creates a weaker euphoric affect than when it bypasses 1st metabolism and is broken down by the kidney or the brain; this is why users inject rather than smoke it. The two acetyl groups that are present that was talked about before on heroin make it fat soluble, which will

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