Tardive dyskinesia is a persistent movement disorder that can result from a prolonged use of antipsychotics and is more prominent with the use of atypical antipsychotics. My preceptor decided to start the patient on Clozapine because of its effectiveness with previous clients that had tardive dyskinesia. According to my preceptor, Clozapine has shown signs of minimizing symptoms of tardive dyskinesia. Treatment did not start immediately as the patient had to get baseline labs, which included absolute neutraphil count, blood glucose, and lipid levels. Patient's weight, height, and BMI were also obtained. AIMS scale was not used with this patient as it does not include tremors. Effectiveness was based on the patients subjective account, and physical observation. Clozapine was started at a low dose and titrated up to 125mg PO QHS. Patient is getting weekly lab work for absolute neutraphil count. To date, there is no sufficient data available that suggests a cure for this movement disorder. However, the question is, among adults, what available treatments have shown the greatest effectiveness in minimizing the symptoms of tardive …show more content…
It is estimated that the annual incidence of tardive dyskinesia is at 5% (Lerner, Miodownik, & Lerner, 2015), with an average prevalence of 20% among those treated with antipsychotics (Khouzam, 2015). When it comes to tardive dyskinesia (TD), along with many other diseases, it is easier to prevent it than to treat it. In preventing TD, many clinicians prefer switching to an atypical antipsychotic because of earlier research that showed a 2.5-fold decrease in the development of TD (Lerner et al., 2015). However, new research is showing that the incidence between typical and atypical antipsychotics is not as significant as previously thought, with an incidence of 5.5% and 3.9%, respectively (Lerner et al., 2015). Regardless of the incidence and prevalence rates, TD deserves much attention because of its potential lasting effects. In treating and managing the symptoms of TD, evidence-based research has shown that there are some treatments that are
risperidone whereas in this one there was a fixed dose to limit breach in blinding and to facilitate comparison between similar groups, also having this fixed dosage helped prevent bias because when using a titrating schedule of dosing in a randomized trial, it tends to show bias toward a desired goal. Risperidone in this study was well tolerated and there weren’t significant differences in weight gain or sedation(13). One of the main things disliked about risperidone is its tendency to increase the incidence of dyskinesia and other extrapyramidal side effects. In this study only mild and transient dyskinesias were seen in only 3 children, however that could be due to the low fixed dosage(13) of the study.
I would recommend atypical antipsychotic drugs such as clozapine because they “appear to be more effective than conventional drugs” (Comer, 2015).
5. What is tardive dyskinesia, and how does it respond to a reduction in the dose of an antipsychotic drug? Rhythmic, repetitive sucking and smacking of the lips and thrusting of the tongue in and out; movement of arms, fingers and toes, reversal is possible if lower dose is given immediately. (Hart & Ksir, p. 173)
Kenny is a teenager who has experienced uncontrollable bodily and facial movements, various uncontrolled vocalizations, and other compulsions such as excessive hand washing and wringing. He has been treated with Clonidine, Haldol, pimozide and buspirone. This patient was diagnosed with Tourette’s Syndrome. Clonidine is a vasodilator that allows for blood to flow more easily to the brain. This lowers blood pressure and helps treat the tics the patient experiences(1). Haldol and Pimozide are antipsychotics that blocks dopamine receptors in the brain. This would help treat the compulsive behaviors (2). Buspirone is used to treat anxiety disorders. It binds to serotonin receptors in
The study by Amato, Minozzi and Davoli (2011) examined five randomized controlled trials to find an efficient and safe medication to treat AWS. The study which had a total of 7333 patients concluded that benzodiazepines were better for controlling seizures when compared to a placebo and antipsychotics (Amato et al., 2011). When comparing benzodiazepines versus anticonvulsants, researchers concluded that the benzodiazepine chlordiazepoxide had better outcomes. No other studies were found which would compare the effectiveness among benzodiazepines for the treatment of AWS.
The most popular medicine to use are anti-psychotic drugs. Close the plane has proven to be very effective in treating this disorder. Although, this medication is likely to cause other serious problems. This medication is likely to be prescribed when one is resilient other antipsychotic medications. Other medications that can help 8 this condition or a rip Rizal, Pullip Raton, quit opinion and that's just to name a few. These medications are accompanied by side effects like blurred vision, rapid heartbeat, skin rashes, dizziness, and drowsiness. Physical effects include restlessness, trimmers, and muscle spasm. And those who you used these medications may develop TD. These medications also can have an effect on women's menstrual cycles. Rapid weight gain can also be a side effect that makes people susceptible to being high at risk for developing baby CDs and / or high
In 1955, antipsychotic medications were introduced to help mental disorders. These medications are usually taken orally in which help relieve symptoms for periods of days. The misuse or abuse of the medications are low. There are three generations of antipsychotic medications. The first generation is known for reducing hallucinations and delusions, but not affecting problems like disorientation or depression. An example would be chlorpromazine, brand name being Thorazine. Some negative side effects of taking the first generation drugs are Parkinson’s-like symptoms, tardive dyskinesia, and weight gain. Next, the second generation drugs minimized the outcome of the individual getting Parkinson’s-like symptoms. An example of this generation would be Clozaril. “A unique feature of Clozaril is the 1 to 2 percent chance of developing a potentially lethal blood disease called agranulocytosis” (Levinthal 282). This disease decreases white blood cells and affects the immune system. If early signs of this disease start to appear the patient will stop taking Clozaril and recover. Lastly, the third generation has shown to be the most effective on schizophrenia. Abilify is an example of this generation drug. It does not have a risk of Parkinson’s, tardive dyskinesia, or diabetes. Abilify blocks specific serotonin receptors in which prevents negative side effects from happening. These different
As we have seen, treatment of schizophrenia with antipsychotic drugs can have impressive results in terms of decreasing active symptoms, although it does nothing to alleviate negative symptoms or to improve cognitive functioning. Unfortunately, this kind of treatment has the drawback of extremely serious and even fatal side-effects. Newer generation atypical antipsychotics offer more hope, as they can treat both active and negative symptoms, and also improve cognitive functioning. Moreover, they have fewer side-effects. However, treatment is complicated by the fact that results are unpredictable; and in addition the side-effects that they do have can be very serious, such as diabetes, which in itself is life-threatening. However, as the potential side-effects are known, the physician has leeway to choose a drug which is a good match for the patient’s clinical profile. Then, once the patient’s symptoms have been much alleviated with an appropriate newer generation atypical antipsychotic, the patient should be able to also benefit from a range of psychotherapeutic interventions. It is argued that this is the best treatment regime to choose, as it is likely to result in the greatest improvement in quality of life, coupled with the lowest risk of potentially devastating side-effects, or of death. This is likely to be better than utilizing cognitive behavioral therapy, the results of which are not reliably known – although research has certainly shown that it is less efficacious
Antipsychotics are generally used to treat psychosis in mental disorders. These disorders include schizophrenia and bipolar disorder (Thyssen et al., 2010). Risperidone is known as an atypical second generation antipsychotic and used in the treatment of a multitude of disorders. This medication can often challenge behavioral problems that are associated with schizophrenia, autism spectrum disorder, bipolar disorder, or attention deficit hyperactivity disorder (Schatzberg & Nemeroff, 2013). It is important for the prescriber to be aware of the side effect and any possible adverse reactions that may occur. There can be many detrimental side effects that someone may not enjoy,
Schizophrenia is a life-long disorder that affects about one percent of the population (Mueser & McGurk, 2004). The cause of this mental illness is still unclear. Studies have suggested that Schizophrenia does not arise from one factor but from a combination of genetic, environmental, and social factors (Liddle, 1987). People diagnosed with Schizophrenia struggle to deal with a multitude of symptoms that make it difficult to function (Mueser & McGurk, 2004). Antipsychotic medications are a popular treatment of the symptoms of Schizophrenia (Mueser & McGurk, 2004). Research is constantly being done to develop these medications to enhance the quality of life of those diagnosed with Schizophrenia.
There must be special attention toward the patient's addiction history before these agents are prescribed. An understanding of the toxicity and side effects of benzodiazepines, abuse patterns and alternative anxiolytic and hypnotic agents may help clinicians to be safe from issues of medico legal case.
The treatment option for psychosis in Parkinson’s Disease is to decrease or discontinue the dose of antiparkinson drugs in the opposite order of their effectiveness.2 The order begins with anticholinergic drugs, followed by amantadine, monoamine oxidase type B inhibitors, catechol-O-methyl transferase inhibitors, and levodopa.2 There is also the treatment option of atypical antipsychotics, specifically clozapine and quetiapine are used in low doses.2 Due to clozapine
Traditional antipsychotics are good at reducing the positive symptoms, but do not reduce the negative symptoms and are classified in low-potency and high-potency which can cause many side effects like; dry mouth, tremors, weight gain, muscle tremors, stiffness, motor disturbances, parkinsonian effects, akathisia, dystonia, akinesia, tardive dyskinesia, and neuroleptic malignant syndrome.
Antipsychotic – Psychotropic drugs are often used for neurochemical problems, behavioral problems, schizophrenia, and other mental disorders. These drugs sometimes cause side effects
A 2010 study tested the effectiveness of a new FDA approved atypical antipsychotic medication Lurasidone. The researchers performed four six week clinical trials to test the