Teicoplanin A3-1 Research Paper

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Teicoplanin A3-1


Teicoplanin A3-1, also known as Antibiotic L 17054, is a glycopeptide antibiotic and possesses potent broad spectrum antibiotic activity against gram-positive bacteria. It is a minor polar analogue of a family of lipoglycopeptides derived from Actinoplanes teichomyceticus. Also, Teicoplanin A3-1 is a common degradation product of teicoplanins A2-1 to 5, resulting from cleavage of the lipoaminoglycoside substituents. Teicoplanins are glycopeptide antibiotics produced by A. teichomyceticus which are effective against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and E. faecalis. As an antibiotic complex, teicoplanin consists of five closely related factors, T-A2-1, 2, 3, 4 and 5 and a more polar factor, T-A3-1. Additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in Bacillus subtilis, which is accompanied by an intracellular
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Due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci
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