Temporal Lobe Epileptogenesis

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Temporal lobe epilepsy (TLS) is a chronic neurological disorder, characterized by recurrent, unprovoked occurrence of seizures. Synchronized hyperactivity of neuron populations caused by imbalance between excitatory and inhibitory synaptic transmissions can result in TLS. Much attention was drawn into BDNF as a potential therapeutic target for TLS in recent years. BDNF is a member of of the neurotrophin family of growth factors. In vitro studies showed that BDNF participate in regulation of neuronal morphology and synaptogenesis and is involved in late LTP. The effects of BDNF are mediated through TrkB receptors. The potential role of BDNF in epileptogenesis comes from a growing body of evidence. Studied have shown that seizures could stimulate
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