Tests on the Medical Effectivness of Phlomis Younghusbandii Mukerjee
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Phlomis Younghusbandii Mukerjee is a perennial herb (family Labiatae) and grows wildly in Qinghai-Tibet Plateau of China. It has been widely used to treat colds, coughs, sores ulceration, rheumatoid arthritis, pneumonia, bronchitis and other diseases for thousands years. In this paper, 5 iridoid glycosides (sesamoside, shanzhiside methylester, 7, 8-dehydropenstemoside, penstemoside and 8-O-acetylshanzhiside methylester) and 3 phenylethanoid glycosides (acteoside, alyssonoside, and isoacteoside) in the four samples from different places were analyzed by HPLC. The acetic acid-induced writhing test, the hot plate test, the carrageenan-induced paw edema test, the xylene-induced ear swelling test, and the acetic acid-induced Evans blue leakage…show more content… Younghusbandii[2-7].
Iridoid glycosides and phenylethanoid glycosides with antinociceptive and anti-inflammatory activities have been isolated from several plants of genus Phlomis [8-9].In our recent study, the related plants, Phlomis umbrosa Turcz and Lamiophlomis rotata (Benth.) Kudo, have showed significant antinociceptive and anti-inflammatory activities in several animal models[10-11].At the same time,six iridoid glycosides: sesamoside,shanzhiside methyl ester, 7,8-dehydropenstemoside, penstemoside, 8-O-acetylshanzhiside methyl ester, phlomiol and three phenylethanoid glycosides: acteoside, alyssonoside, and isoacteosidewere isolated and identified from P. Younghusbandii. Among of these compounds, 7, 8-dehydropenstemoside, and three phenylethanoid glycosides were isolated from this plant for the first time [12].In this paper,the acetic acid-induced writhing test, the hot plate test, the xylene-induced ear swelling test, and the acetic acid-induced Evans blue leakage test were used to investigate the antinociceptive and anti-inflammatory activities of the aqueous extract of this plant.5-iridoid glycosides (sesamoside, shanzhiside methylester, 7, 8-dehydro- penstemoside, penstemoside and 8-O-acetyl-shanzhiside methylester) (Fig. 2)and 3-phenylethanoid glycosides (acteoside, alyssonoside, and isoacteoside) (Fig. 3)in three samples of P. Younghusbandii from different places were