Thalassemia is Commonly Called Anemia

Sickle Cell Anemia is a very serious disorder and people suffer from it every day. It is a genetic disorder that causes the hemoglobin in the red blood cell to distort and form into a sickle like shape. The name comes from the shape of the blood cell after it is mutated. A person who has sickle cell anemia got it from inheriting from the parents. It is the most common inherited disorder in the United States. It is also has four other names this disorder can go by HbS, Hemoglobin S Disease, SCD, and Sickle Cell .(https://ghr.nlm.nih.gov)the blood cell is formed wrong turning it into a sickle or crescent shape. Sickle cell is only a disorder. It can also be treated a lot of different ways.

believed that genetically aberrant hemoglobin evolved as a protection against malaria."(2) It has also been said that, "People with a single copy of a particular genetic mutation [sickle cell trait] have a survival advantage. One copy of the mutation confers a benefit." (3) Its quite interesting to find that original purpose of this gene was

Sickle Cell Disease is an autosomal recessive genetic disease that occurs due to a mutation in the β-globin gene of hemoglobin. Autosomal meaning that it is not linked to a sex chromosome, so either parent can pass on the gene to their child. This mutation is a result of a single substitution of amino acids, Glutamic for Valine at position 6 of a β globin chain. The presence of this mutation causes

Sickle cell anemia (SCA) is an autosomal recessive genetic disorder. This missense mutation is characterized by mutant beta globin subunits that tend to stick together (Cummings, 2014). As a result, abnormally shaped red blood cells are produced by this disorder. The erythrocytes are sickle or crescent shaped. Sickling occurs under hypoxic conditions, in which there is insufficient supply of oxygen delivered throughout the body (Sun & Xia, 2013). In order to inherit this monogenic disease, one copy of the sickle globin gene from each parent must be passed on to the offspring (Ashley-Koch,

Every society has many issues. Some of these issues are small and the others are big. These issues could be economical issues,

Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise

Hemoglobin is a protein within erythrocytes responsible for binding, carrying, and delivering oxygen throughout the body. These disorders are inherited and therefore not contagious. For an individual to have sickle cell anemia each of their parents must have an abnormal hemoglobin gene and both of these genes must be expressed.

But what does this mean, well first a mutation is an abnormality much in the way that cancer is an abnormal growth within the body. These are mutations, unfortunately we don’t get the same types of mutations that the X-Men have. Our body’s are made so that everything perfectly fits in each hole or socket, well red blood cells are normally round and smooth. Red blood cells are designed to be able to flow smoothly through blood vessels which is why they are smooth and round. Like mentioned earlier Sickle cell anemia is a mutation of the hemoglobin or the blood cells themselves. The blood cells stack on one another into long tube like structures. The cells become sickle shaped and become rigid. The sickling starts on the chromosome 11. While the cells are stacking up they are damaging vital organs such as the lungs and the heart. Everyone gets a copy of the hemoglobin gene from each parent. If both genes are carriers of the sickled trait, there will be high probability that the offspring will have Sickle cell anemia. Sickle cell is not contagious and cannot be caught, it is passed along genetically. Through research we have found that there are different types of the sickling disease. There is Hemoglobin SS (Sickle cell anemia), hemoglobin SC and hemoglobin sickle betathalassemia which is known as Mediterranean

Sickle cell anemia (SCA) is one of the most common severe monogenetic disorders in the world. (1).SCA is an inherited blood disorder caused by a single point mutation in one of the genes encoding hemoglobin (2).Hemoglobin (Hb) it is an oxygen transporting molecule, carrying oxygen from the lungs to the tissues and takinge carbon dioxide away from the cell. Hb, made of four globin protein chains two alpha and two beata chains (pic).http://themedicalbiochemistrypage.org/images/hemoglobin.jpg

Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease. Affected people have a different change (mutation) in each copy of their HBB gene: one that causes red blood cells to form a "sickle" or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin. Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a reduced amount of normal hemoglobin (called sickle beta plus thalassemia). The presence of sickle-shaped red blood cells, which often breakdown prematurely and can

Thousands of years ago, a genetic mutation occurred in people from the Mediterranean basin, India, Africa, and the Middle East. As the Malaria Epidemic attacked people of these countries, carriers of the defective hemoglobin gene survived. Carrying one defective gene means that a person has a sickle cell trait. Two parents with the trait will produce a child with sickle cell anemia. People of these countries migrated and spread to other areas. In the Western Hemisphere, where malaria is not much of a problem, having the abnormal hemoglobin gene has lost its advantage. Any child born from parents that each has the trait will be born with the disease.

The genes for haemoglobin behave exactly as predicted by Mendel’s Law of Inheritance. A child must inherit one haemoglobin

This paper is written about the disease Alpha Thalassemia and it affects from the cellular to how the organism is impacted. It will cover the basis of the disease including inheritance and symptoms. Then, how and where the mutation occurs that causes the disease. The paper will then discuss the protein that is involved in the disease and how the mutation affects the production of the protein. The production can either be still functioning, completely shut down, slowed, or part of the protein could still function while the other side does not. The impact of the mutation on the cellular level and the organ system if impacted will be discussed. After this, how the mutation will affect daily life and if the organism can survive to live a normal lifespan will be talked about. Finally the paper will end on the future of the disease and treatments.

There are many disorders that affect the red blood cells. The most common disorder is sickle cell anemia. Sickle cell anemia is a hereditary blood disorder that affects the protein hemoglobin in red blood cells (“What is Sickle Cell Disease”, 2015). The protein hemoglobin S is changed and this affects the way it works. Sickle cell anemia gene is passed down by the parents. If one parent has the hemoglobin S gene of sickle cell, the child will have the sickle cell trait (“What is…”, 2015). If both parents have the gene of sickle cell, the child will have sickle cell disease. Sickle cell is most common in African Americans (“What is…”, 2015). Common symptoms of sickle cell anemia are fatigue, pain in the back, chest, legs, and arms and swelling

Thalassemia is basically a name for similar groups of inherited blood diseases that involve missing or abnormal genes regarding the protein in hemoglobin which is the red blood cells that carry oxygen throughout the body. I will discuss the different types of Thalassemia, how Thalassemia is diagnosed, and the treatments available. I will also discuss the complications and side effects of the treatments, the disease’s causes and effects, and how it is more dominant in some parts of the world than others. Thalassemia is a blood disorder which means the body makes fewer healthy red blood cells and less hemoglobin. Hemoglobin is a protein that carries oxygen throughout the body and having less hemoglobin leads to anemia. Alpha globin and beta