The Accurate Cause Of Parkinson's Disease

Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016).

Parkinson 's disease is a progressive neurologic degenerative disease of the Central Nervous system. The brain produces Dopamine and Norepinephrine, which are chemicals needed for smooth muscle movement and coordination, heart rate, and blood pressure. Dopamine and Norepinephrine are released by basal ganglions that are produced in a bundle of nerve cells in the brainstem called substantia nigra. In Parkinson 's patients, the substantia nigra are destroyed and neither of the chemicals can be released into the body. (3) The decrease in Norepinephrine causes heart arrhythmia and low blood pressure, causing the person to get dizzy upon standing or tire easily. The lack of Dopamine, the smooth muscle movement and coordination controller is now gone, or significantly decreased, resulting in the first signs of Parkinson’s disease, pill-rolling, a one handed tremor and a decreased appetite. (2)

Parkinson’s disease is a progressive neurological condition which occurs when the brains nerve cells that contain/produce dopamine die, without the chemical

Parkinson’s disease is a “neurodegenerative disorder of the basal nuclei due to insufficient secretion of the neurotransmitter dopamine” (Marieb & Hoehn, 2013, p. G-17). The cause of Parkinson’s disease is unknown, but many factors play a role in the development of Parkinson’s disease. One factor that has been found in an individual who has Parkinson’s disease causes over activity of targeted dopamine-deprived basal nuclei. This over activity is caused by the breakdown of neurons that release dopamine in the substantia nigra (Marieb & Hoehn, 2013). Another factor that is present in a person who has Parkinson’s disease, is the presence of lewy bodies in the brain stem ("What is lbd?," 2014). Lewy bodies are unusual

Parkinson disease (PD), also referred to as Parkinson’s disease and paralysis agitans, is a progressive neurodegenerative disease that is the third most common neurologic disorder of older adults. It is a debilitating disease affecting motor ability and is characterized by four cardinal symptoms: tremor rigidity, bradykinesia or kinesis (slow movement/no movement), and postural instability. Most people have primary, or idiopathic, disease. A few patients have secondary parkinsonian symptoms from conditions such as brain tumors and certain anti-psychotic drugs.

Parkinson's Disease has a genetic component, which plays a role in the etiology. Environmental factors can too, such as exposure to toxins like pesticides or workplace hazards like industrial use of heavy metals. Head injuries, damage to the brain from free radicals, and a stroke or brain tumor can contribute as well. This disease is chronic and becomes progressively

The disease that I have chosen is Parkinson’s Disease it is a disease that causes uncontrollable shaking in the body that your brain is causing. Parkinson’s Disease is caused because your body do not produce enough dopamine. Some causes for Parkinson’s disease can be genetics, and environmental triggers. For example, if you are a exposed to certain toxins then you have a miniscule chance of getting parkinson’s but it is very rare. Some other causes for parkinson’s can be having the presence of Lewy bodies in your brain. Which are clumps of specific substances that are found in the brain. These Lewy bodies are an important part to the cause of Parkinson’s disease but completely the cause. But, scientists believe that important factor to the cause is a protein that is found in these Lewy bodies. This protein is called alpha-synuclein, which is a protein that the cells in your body can not break down and therefore it could be a harm to the cells around it in the brain that control the nervous system. Another point is genetics in which you can get it from past generations because the creation of the protein the brain is passed down. Though it is very rare it is still very possible that you could get it and you can get Parkinson’s Disease.

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).

Parkinson’s Disease is a very common disorder these days. Over 10 million people live daily with Parkinson worldwide. Parkinson’s Disease was named after an English surgeon James Parkinson who wrote a detailed description essay called Shaking Palsy in 1817. The average age for Parkinson’s Disease is between 45 to 70 years old but you can also have juvenile or young onset as well. Most common symptoms of Parkinson are tremors, bradykinesia or akinesia, or rigidity or stiffness, and balance disorder. Parkinson’s Disease doesn’t have a cure and the cause is unknown it could be a number of things genetics, environmental triggers, age, or gender. Parkinson’s Disease happens because the dopaminergic neuron dies and

Parkinson also known as idiopathic Parkinson basically targets dopamine in brain nerve cells specially in mid brain and substantia nigra causes cell death. In Parkinson disorder levels of dopamine are decreased in brain. In early stage of Parkinson signs are very oblivious which includes tremors (shaking of hands), muscle rigidity and slowness of movement.

A variety of explanations might also account for reports by those dying of meeting the deceased. Parkinson's disease patients, for example, have reported visions of ghosts, even monsters. The explanation, Parkinson’s involves abnormal functioning of dopamine, a neurotransmitter that can evoke hallucinations. And when it comes to the common experience of reliving moments from one's life, one culprit might be the locus coeruleus, a midbrain region that releases noradrenaline, a stress hormone one would expect to be released in high levels during trauma. The locus coeruleus is highly connected with brain regions that mediate emotion and memory, such as the amygdala and

Parkinson’s disease is a progressive condition that damages the brain throughout the years. A rate of development varies amongst the individuals and can take many years to impact in the life. An individual life expectancy receiving a proper treatment is normal, detecting earlier reduces shortening a life. However, with the advanced signs increases a disability and have a poor disability. After a 10 to 15 years of Parkinson’s disease affect daily life. As the symptoms worsen a problem arises. An individual will have a difficult to communicate as the disease progress, lose weight, and have a trouble swallowing. Also, a complication with a balance falling, a cognitive impairment and complication with behaviours.

That was a very good assignment. I have read several etiologies for Parkinson’s disease (PD). The real cause of PD is still unknown according to my opinion. Some researchers conclude that PD may cause by a progressive impairment or deterioration certain nerve cells (neurons) in the brain gradually break down or die. There is considerable controversy surrounding the possibility of a genetic cause of Parkinson's disease. You have stated that the pathogenesis is multifactorial with genetic predisposition, exogenous and endogenous toxins. To me, the genetic cause of Parkinson's disease is considerable controversy. According to NHS Choices (2016), a number of genetic factors have been shown to increase a person's risk of developing Parkinson's disease,

Parkinson disease (PD) is a common neurodegenerative disease with unknown etiology. PD is commonly referred to as a “motor disease,” reflecting its clinical symptoms, including resting tremors of extremities, muscular rigidity, shuffling gait, stoop posture, and bradykinesia (1). The underlying pathology of PD is progressive neuronal loss, particularly in the substantia nigra pars compacta (SNc), and the presence of abnormal protein- rich aggregates—known as Lewy bodies— in the remaining

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,