The And Characterization Of Project Mn ( Bpmp )

The objective of this lab was to create a ketone through an oxidation reaction using a using a secondary alcohol and oxidizing agent in order to use that ketone in a reduction reaction with a specific reducing agent to determine the affect of that reducing agent on the diastereoselectivity of the product. In the first part of this experiment, 4-tert-butylcyclohexanol was reacted with NaOCl, an oxidizing agent, and acetic acid to form 4-tert-butylcyclohexanone. In the second part of this experiment, 4-tert-butylcyclohexanone was reacted with a reducing agent, either NaBH4 in EtOH or Al(OiPr)3 in iPrOH, to form the product 4-tert-butylcyclohexanol. 1H NMR spectroscopy was used to determine the cis:trans ratio of the OH relative to the tert-butyl group in the product formed from the reduction reaction with each reducing agent. Thin-layer chromatography was used in both the oxidation and reduction steps to ensure that each reaction ran to completion.

In the controlled oxidation reactions of 1-butanol and 2-butanol with KMnO4, there is also a formation of water. The primary alcohol 1-butanol, reacted with KMnO4 to create butanal, an aldehyde, and water as products. Also the secondary alcohol, 2-butanol and KMnO4

The Hydroxyl group on alcohols relates to their reactivity. This concept was explored by answering the question “Does each alcohol undergo halogenation and controlled oxidation?” . Using three isomers of butanol; the primary 1-butanol, the secondary 2-butanol and the tertiary 2-methyl-2-propanol, also referred to as T-butanol, two experiments were performed to test the capabilities of the alcohols. When mixed with hydrochloric acid in a glass test tube, the primary alcohol and secondary alcohols were expected to halogenate, however the secondary and tertiary ended up doing so. This may have been because of the orientation of the Hydroxyl group when butanol is in a different

The purpose of this experiment was to synthesize the Grignard reagent, phenyl magnesium bromide, and then use the manufactured Grignard reagent to synthesize the alcohol, triphenylmethanol, by reacting with benzophenone and protonation by H3O+. The triphenylmethanol was purified by recrystallization. The melting point, Infrared Spectroscopy, 13C NMR, and 1H NMR were used to characterize and confirm the recrystallized substance was triphenylmethanol.

In a project the communication level is a very important part from the beginning to the end of project close out and completion stage. This method in the plan is extremely necessary and it is a needed tool that helps assist the project team, the stakeholders, and the executive team of Enterprise. This tool is effective and it makes sure all members involved with the project is on the same level of understanding, it makes sure all involved stays updated on the

“Every project has a beginning and an end” (Zaccagnini & White, 2014, pp. 455). Previous chapters have discussed the closure of the project and the need for a formal evaluation of the project’s impact on the organization in which it was implemented. The most significant reasoning behind the formal evaluation process of the DNP project is the need for translation of learned knowledge to practice (Zaccagnini & White, 2014). Translation science is an essential part of the overall reasoning behind the project, but the stakeholders involved must be provided the information and subsequent recommendations for further improvement within their organization (Zaccagnini & White, 2014). This chapter discusses the various data and how they are interpreted. Project recommendations are evaluated, acknowledging the interpretation of the data, to determine how the project interventions made an

Diamond Cluster Entertainment is trying to build a solid relationship with their loyal customers. For the past few year customer satisfaction have declined

To secure the parameter of the facility with security cameras within four weeks and not to exceed $20,000 for the entire project cost.

A highly chemo-selective and efficient method for the oxidation of sulfides to the corresponding sulfoxide in the absence of any solvent and thiols to their corresponding disulfides in ethanol with aqueous hydrogen peroxide as oxidant and the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in water at room temperature using heterogeneous ZnO (acac)2 catalyst grafted on mesoporous silica MCM-41 has been developed. The simplicity in operation, general applicability, Short reaction times, easy purification, high yields, mild conditions, and recyclability make this procedure more

The oxidation reaction occurs as a two-step reaction. The first step involves the formation of chromate esters and the second step is an elimination reaction that will produce the carbonyl group necessary to make either a ketone or an aldehydes. The reaction is hallmarked by the breaking of a C-H bond and the formation of a C-O bond (James, 2014). Specifically when oxidizing alcohols, it is important to note that primary alcohols can be converted to aldehydes as well as completely to carboxylic acids, secondary alcohols are converted to ketones and no further, and tertiary alcohols cannot be oxidized. The oxidizing agent removes the hydrogen from the –OH group and the hydrogen from the C-H group attached to the –OH group in a compound. Tertiary alcohols cannot be oxidized because they lack the C-H bond that is present in both the oxidation of primary and secondary alcohols (Clark, 2003).

By analysing the results collected in the experiment, the overall outcomes suggests that Manganese Oxide, Copper Oxide and Lead Oxide are the 3 Oxides that decomposed Hydrogen Peroxide leading to large productions of Oxygen. Starting with an initial O2 concentration of an average 20.50%, the final concentrations of O2 after 120 seconds were 47.73% for Copper Oxide, 46.5% for Manganese Oxide and 46.37% for Lead Oxide, showing that they performed quite well as catalysts. Although, all three of them showed a similar amount O2 production, Manganese IV Oxide was the quickest to start working and showed a considerable O2 concentration relatively quickly. Lead and Copper Oxides were not very quick at the offset but caught up with Manganese IV Oxide

Assume the role of a project manager overseeing the construction of a 15-mile road. The work is uniformly spread over 12 weeks. Suppose the client has approached your firm and has requested an additional 3 miles to be added to the road without an adjustment to the project completion date. Among the 7 basic tools of quality, which tools would you recommend to control the quality in the given situation? Justify your choices with examples from your professional experience and list the merits and demerits of using the tools you choose.

The M in PMS stands for Morality, the way you have to look at a situation from all angles in order to get an answer. This is often more conflicting than not analyzing a situation.

Nishioka et al. (2000) have observed the higher frequency of 1G/2G, 2G/2G genotypes in the patients of endometrial adenocarcinoma than in a normal population. Rutter et al.(1998) reported that guanine (G) insertion at -1607 bp in the MMP-1 promoter creates an Ets binding site at 5′-GGA-3′ flanking an AP-1 site. This 2G allele has significantly higher transcriptional activity in cancer cells of melanoma cells than 1G allele. In addition, MMP-1 expression and polymorphism in the promoter region have been detected in ovarian carcinomas (Kanamori et al., 1999). A pilot study of Morozova et al. (2012) suggested that the 2G (-1607) MMP-1 genotype may be a potential risk marker of Myohyperplasia and endometrial hyperplasia in the Russian

We next studied the effect of PMA alone on A1-40 conformation. As speculated, we observed a PMA directed rapid sheet induction in A1-40 at equimolar concentration at pH 7.4 where A1-40 carries a net charge of -2.9 (Fig 2b). A decrease in the buffer pH from 7.4 to 2.5 reduces the electrostatic interaction between PMA and A1-40 (net charge +6.7) and resulted a random coil A1-40 conformation (Fig 2b, red graphs). Moreover, we observed -helical CD spectra for A1-40 interacting to DMPC nanodiscs at pH=5.5 where A1-40 nearly carries no charge (Fig 2b). Overall the CD results suggested that at physiological pH, the cationic PMA binds strongly to the anionic A1-40 followed by a rapid structural conversion.