The antibiotic bomb Resistance among bacteria to current antibiotics may cause a new pre-antibiotic era, where common bacterial infections become as lethal as before the invention of the first antibiotic penicillin. With resistance on the rise, ‘simple’ surgery, cancer treatment and organ transplantation may become impossible.[4] Despite this very big and real threat[1], big pharmaceutical companies have abandoned or decreased their efforts to develop new antibiotics, while the demand for new and broad –and small– spectrum antibiotics is increasing.[2] [3] In this paper I will give an outline of the main factors why big pharmaceutical companies are no longer developing new antibiotics and I will attempt to pose possible solutions –call it Utopian solutions– that may turn the tide before it is too late. Antibiotics differ from many other drugs in the fact that the treatment is for a very short time compared to drugs used to treat hypertension, diabetes, Parkinson’s, or cancer. The latter disorders have in common that the treatment, from the moment of diagnosis, is life-long. The treatment period for antibiotics is only a few weeks, making the return of investment poor. Increasing demands of authorities in both development and marketing phase and in legislation increase the costs of new antibiotics.[1] [3] Besides the two mentioned arguments which boil down to ‘market forces’ and ‘regulatory affairs’, there is a third factor in the way to a healthy system with new
In the last decade, the number of prescriptions for antibiotics has increases. Even though, antibiotics are helpful, an excess amount of antibiotics can be dangerous. Quite often antibiotics are wrongly prescribed to cure viruses when they are meant to target bacteria. Antibiotics are a type of medicine that is prone to kill microorganisms, or bacteria. By examining the PBS documentary Hunting the Nightmare Bacteria and the article “U.S. government taps GlaxoSmithKline for New Antibiotics” by Ben Hirschler as well as a few other articles can help depict the problem that is of doctors prescribing antibiotics wrongly or excessively, which can led to becoming harmful to the body.
The development of antibiotics was an important advancement in 20th century medicine. Previously deadly infectious diseases are now routinely treated with antibiotics. Moreover, for modern-day medical procedures such as chemotherapy treatment to be successful, antibiotic use is necessary. For these reasons, the prospect of bacteria developing widespread resistance to antibiotics is a major concern as it would render many modern-day medical therapies unviable.
Antibiotics, composed of microorganisms such as streptomycin and penicillin, kill other infectious microorganisms in the human body. At one point, antibiotics were considered to have “basically wiped out infection in the United States”, but due to their overuse and evolutionary
Fleming in 1928. Penicillin helped to treat some common infections: step throat, boils, it would heal wounds quicker, as well as treat more serious infections such as meningitis and pneumonia. Antibiotics usually kill only weak bacteria and after some years of antibiotic usage stronger bacteria have not only survived but also became resistant to the old cure. “Doctors have started to prescribe antibiotics to cure conditions such as ear infections, sinusitis, bronchitis, non-specific upper respiratory tract infections and even common colds and flu… According to the Director of Antimicrobial Resistance, Dr. Richard Besser, each year US physicians write $50 million worth of prescriptions that are ineffectual and unnecessary.” (Elisa Bussey). The more doctors were prescribing antibiotics, the bigger the number of people who become resistant to them. Most of the European countries prescribe antibiotics to kill bacteria only in cases of life threatening conditions. Patients in the US have become accustomed to receiving antibiotics for almost any health concerns and with time, patients have started to expect such prescriptions as a norm.
Antibiotics are inarguably one of the greatest advances in medical science of the past century. Although the first natural antibiotic Penicillin was not discovered until 1928 by Scottish biologist Alexander Flemming, evidence exists that certain plant and mold growths were used to treat infections in ancient Egypt, ancient India, and classical Greece (Forrest, 1982). In our modern world with the advent of synthetic chemistry synthetic antibiotics like Erithromycin and its derivative Azithromycin have been developed. Antibiotics have many uses including the treatment of bacterial and protozoan infection, in surgical operations and prophylactically to prevent the development of an infection. Through these applications, antibiotics have saved countless lives across the world and radically altered the field of medicine. Though a wonderful and potentially lifesaving tool, antibiotic use is not without its disadvantages. Mankind has perhaps been too lax in regulation and too liberal in application of antibiotics and growing antibiotic resistance is the price we must now pay. A recent study showed that perhaps 70% of bacterial infections acquired during hospital visits in the United States are resistant to at least one class of antibiotic (Leeb, 2004). Bacteria are not helpless and their genetic capabilities have allowed them to take advantage of society’s overuse of antibiotics, allowing them to develop
Since the introduction of penicillin to the public in 1942, antibiotics have gained widespread use throughout the world. The drug has allowed society to make advancements in medicine, increase an individual’s personal well-being, extend life expectancies, and stop and prevent infections. Antibiotics are one of the largest backbones to maintaining personal health in society today, yet there may be a day when we are no longer able to depend on antibiotics to fight infections. In the essay “Imagining the post antibiotic future”, Maryn McKenna establishes the importance of antibiotics to juxtapose how devastating life would be without them.
The disclosure by Alexander Fleming of penicillin opened up a totally new time of chemotherapy. Antibiotics are the chemotherapeutic specialists that kill or inhabit the development of microorganisms. These substance operators are utilized to treat malady by wrecking pathogenic microorganisms or restraining their development at focus sufficiently low to enough to avoid undesirable harm to the host (Dafale et al., 2016).
Research has revealed how overprescribing antibiotic creates several adverse outcomes, including the development of multidrug resistant organisms, Clostridium difficile infection, and increased costs of health care (Myung et al., 2015). The Consumer Report (2015) raised concern for the overuse of antibiotics and how it leads to the loss of the ability to treat serious infections. Doctors,
The misuse of penicillin and other antibiotics however is causing the growing problem of antibiotic resistance in which seemingly harmless infections turn to be deadly and dangerous. Antibiotics are not only casually used as treatments for bacterial infections, but are also used in agriculture and veterinary medicine, creating controversy on the proper uses of antibiotics. As advancements in the medical fields proved to be beneficial for a short period of time, today the misuse of these innovations are creating more and more problems that have proven to be dangerous to the accustomed health of the global population. Antibiotics were not always considered to be a superficial medication and, in fact, have been naturally used for millions of years, like with ants and their symbiosis with antibiotic producing fungi. Humans do not fully realize the value that antibiotics have brought to the population and do not take measures to preserve their use. In contrast, humans take for advantage the natural benefits that is given to them to overly benefit themselves, such as while creating revenue through mass production despite warning from scientists. This selfish misuse leads to consequences in which the future will have to provide solutions for, and perhaps even follow in the ants’ footsteps.
Antibiotics-resistant organisms have become one of the most serious threats to public health, infecting over two million people and killing approximately 23,000 people annually.1 According to the CDC, “total inappropriate antibiotic use,” such as prescribing unnecessary antibiotics or giving the wrong dose or duration, makes up to 50% of all outpatient antibiotic use,2,3 and in 2009, the United States spent $10.7 billion on antibiotics, indicating that there is a lot of potential money to save.4
With all of our modern advances, it seems somewhat strange that chronic health problems have become so commonplace. When antibiotics were discovered, they predicted the end of disease. Instead, we now have a world full of frightening antibiotic resistant infections.
Antibiotics are amongst the most important medical discoveries and their introduction represents a remarkable success story (Hedin, 2011). The term antibiotics literally means against life (Walsh, 2000). Thus antibiotics can be used against any microbe such as bacteria, viruses, fungi, and protozoa. However, some people use the term to only apply to bacteria, but in this paper, the more appropriate term will be used.
Millions of lives are saved every single day because of antibiotics treating common infections, allowing organ transplants, as well extending the average lifespan by decades. About half of the emergency cases treated in the intensive care units in the video “Antibiotic Resistance—Catalyst” are suffering from bacterial infections as well as coming to terms that it is no longer treatable, because bacteria are rapidly becoming resistant to all the antibiotics we have. By overusing this incalculable medical resource, we are basically risking the loss the potency of antibiotics, which is a threat to the human race.
The overuse of antibiotics has been a problem for well over a decade. This misuse leads to many nonvisible problems arising within the human population. As the use of antibiotics increases, the number of antibiotic resistant bacteria also increases. When bacteria become resistant to an antibiotic, another antibiotic must be used to try and kill it and the cycle becomes vicious. Michael Martin, Sapna Thottathil, and Thomas Newman stated that antimicrobial resistance is, “an increasingly serious threat to global public health that requires action across all government sectors and society” (2409).
According the World Health Organization (WHO), antibiotic resistance is one of the world’s greatest health threats to date (Haddox, 2013). In the article, The Health Threat of Antibiotic Resistance, Gail Haddox (2013) discusses the danger antibiotic resistance poses in today’s society and strategies to prevent the expansion of antibiotic resistance. In Europe alone, an estimated 25,000 deaths have been attributed to multi-resistant infections (Haddox, 2013). Common infections are now harder to treat due to the increased resistance to antibiotics across the world, in fact some are becoming untreatable. Antibiotics should be treated like oil, a non-renewable resource (Haddox, 2013).