The Antidiabetic Effects Of Vitamin D3

Hyperlipidemia is the abnormal elevation of any lipoproteins present in the blood. HMG-CoA reductase inhibitors (statins) are commonly used for the treatment of hyperlipidemia, specifically lowering the levels of low-density lipoproteins (LDL) levels. As with most classes of medications, there are many potential side effects. A less common but serious side effect of statins is myopathy. Myopathy is a dose-related side effect that causes skeletal muscle weakness, aching, cramping, pain, stiffness and tightness. The mechanism of this occurrence is unknown, but as will be shown, there is a possible correlation between low vitamin D levels and increased occurrence of statin induced myopathy. The vast numbers of patients on statins results in a high number of patients with statin-induced myopathy throughout the world. This consultation will determine whether vitamin D prophylaxis is safe and effective in the prevention of statin-induced myopathy.

Dyslipidemia is characterized by increased total cholesterol levels, low-density lipoprotein-cholesterol levels (LDL-C), triglyceride levels (TG), and low high-density lipoprotein-cholesterol levels (HDL-C) (1). Most of the cholesterols in the body (60-70%) are transported to liver cells in the form of LDL-C through direct interaction with specific LDL receptors (1). Dietary intake of foods that are high in cholesterol and saturated fats (such as egg yolk, butter, fast food) activates a feedback mechanism which lowers the activity of LDL receptors. As a consequence, LDLs are no longer being efficiency recycled to the liver and plasma LDL levels increased dramatically (1). The excess circulating LDLs are able to migrate through endothelial

2. Vitamin D- A group of steroids; resistant to heat, oxidation, acids, and bases; stored in liver, skin, brain, spleen, and bones. Promotes absorption of calcium and phosphorous; promotes development of teeth and bones. Sources: produces in skin exposed to ultraviolet light; in milk; egg yolk; fish liver oils; fortified foods. Excess: Diarrhea calcification of soft tissues, renal damage. Deficienceis: Rickets,bone decalcification and weakening.

This indicates that the metabolism of proteins was apparently affected by Ch.t extract. The improvement on the levels of protein and albumin in the diabetic treated groups show that Ch.t extract have significant effect in glucose and protein level because insulin inhibit gluconeogenesis from protein [ ] or could be due to improvement in renal function. This affirmative agrees with the fact that the weight of skeletal muscles was significantly increase in diabetic rats treated with Ch.t extract. The decrease in albumin level documented for diabetic rats may be due to liver massive necrosis, deterioration of liver function, hepatic resistance to insulin and glycogen impairment of oxidative phosphorylation[ ].Under the same experimental conditions serum globulin level revealed an appreciable decrease[ ]. The renal pathogenesis is related to duration of diabetes, the most devastating complication with diabetes is nephropathy[

From the electronic database searches, several articles were appropriate. The first, "Vitamin D deficiency and depression in adults: systematic review and meta-analysis", was designed to find a relationship between Vitamin D and depression (Anglin, Samaan, Walter, & McDonald, 2013). Although, limited by the lack of random control trials, the data was presented in a uniform and consistent manner (Anglin et al., 2013). The results were in line with their goal, finding that low Vitamin D levels did correlate with increased depression (Anglin et al., 2013). Second, Meehan, and Penckofer, provided their inductive, exploratory opinion of "The role of Vitamin D in the aging adult" (2014). Although, the study was short and depression symptoms were self-reported, it, nevertheless, showed a correlation between low levels of Vitamin D and depression symptoms (Meehan, & Penckofer, 2014). The third article, "Vitamin D supplementation to prevent

Boosting your immune system,Vitamin D helps your body regulate the absorption of your calcium and phosphorus.

Insulin resistance can also be caused by increased triglycerides and free fatty acids intake. This is due to the effect Triglycerides and free fatty acids have on insulin stimulated signal pathways, translocation protein-4 and glucose uptake (Choi, Jung, Park, & Song, 2004). It is found that CLA has a regulatory effect on glucose and lipid metabolism regulators. CLA affects the PPAR-y ligand, a major receptor that influences the expression and transcription of genes that are related to the metabolic effects of glucose and lipids. Such protein regulators as aP2, insulin-dependent glucose transporter 4, FATp, ACS and adiponectin are all influenced by increased CLA. (Xiao-Rong Zhoua, Chang-Hao Suna, Jia-Ren Liua, b, Dan Zhaoa, 2008). It was also theorized that CLA may act on other glucose regulators such as phosphoenolpyruvate carboxylase, glucose-6-phosphate, glucokinase, sterol-regulation element finding protein, acyl coenzyme A oxidase, fatty acid synthase and uncoupling protein. Testing done on rats with a mixture of cis 9, trans 11 and trans 10, cis 12 CLA had found that the only effected regulatory agents were regulators involved in gluconeogenesis such as Phosphoenol carboxykinase and transcriptional factors, sterol-regulating element binding protein-1c and PPAR-y (Choi, Jung, Park, & Song, 2004). The main regulatory effect on insulin resistance was the effect on ligand PPAR-y, a key regulator in lipid homeostasis. Mixtures of CLA isomers consisting of cis 9, trans 11 and trans 10,cis 12 effect gene expression of PPARy mRNA in rats. It was found to have affected the levels of aP2, FATP, ACS and adipoenectin mRNA expression in adipose tissue. CLA increased These regulatory proteins resulting in an uptake of free fatty acids into the adipose tissue and decreasing uptake into the muscle tissue. This has been found to improve muscle insulin

However, his news article does not states the dangers of overdosing on vitamin D and is biased towards taking the supplements. Blackstone emphasizes that many of the people in the United States are lacking vitamin D, therefore, everyone should be eating enough or taking vitamin D supplements because the studies have proved it. Even though this article’s purpose is to inform the readers on vitamin D, Blackstone is not certified to say to people that Americans should be eating a lot of vitamin D just be safe. It is the job of a doctor or a dietician to be telling their patients how much of this essential vitamin they should take in a

Figure 3 shows the percentage of gain in body mass compared to the initial mass of the body at the 6, 12, and 18-week time points. The vitamin D deficient groups showed the lowest percentage of body mass gain compared to the vitamin fed groups. Even though smoking was independent, and played no affect in body mass, the smoking vitamin D deficient mouse showed the lowest body mass gain at every single point.

Vitamin intake is a commonly overlooked necessity in basic nutritional health. What most people do not know is that certain vitamin deficiencies can cause many health risks and problems. Many people believe that are getting all the vitamins they need from their diet, however most of the time they are not. One of the most common vitamin deficiencies is the low intake of Vitamin D. There are some vitamins that are produced by the body such as vitamin K; however some of the most important vitamins are not produced by the body. Vitamin D is one of the vitamins that our body needs to function correctly that is not naturally produced by the body. Vitamin D can be consumed through

The existence of a relationship between vitamin D and calcium metabolism is well known , but recently researchers have begun to suspect that vitamin D can affect many other important biological processes, including tumor progression. However, it is not clear exactly at what stage of cancer development vitamin D may affect.

The study also showed that Vitamin D deficiency decreased FEV1, especially during asthma exacerbations.4 Some weaknesses of this study may be that the surveyors compared the results obtained in their study to those studies that were done “in vivo”.4 The strengths of this study include the time span over which it took place as well as the amount of factors taken into account to retrieve the appropriate data necessary to make the conclusion that a deficiency of vitamin D is related to asthma exacerbations and poor lung function.

A study published in Archives of Internal Medicine found that 75 percent or more of American teens and adults are deficient in Vitamin D. That is why we have so many serious illnesses, like cancer, diabetes and heart disease (Huff, 2010).

The results of the study reinforce previous findings that back clinical data, advocating for the use of dietary supplements alongside making lifestyle changes. In 1999, a study looking at the effectiveness of Reducol and low fat diet in lowering cholesterol levels was conducted by McGill University in Montreal, Canada. In the study involving 32 subjects, patients who took 1.g a day of Reducol branded sitosterol with sterol combination recorded a remarkable LDL reduction of up to 24% compared to a reduction of 9% for those who relied on low fat diet. In the study, no remarkable increases in plasma sterol were recorded, a fact that suggests the sterols were not absorbed.

Vitamin D is an important micronutrient that is involved in the metabolism of calcium and phosphorous, and helps establish strong bone health (1). Recent studies have shown promising results of supplementing vitamin D to pregnant women with gestational diabetes mellitus (GDM). Despite advances in medicine and health GDM is still prevalent among pregnant women, resulting in possible complications to pregnancy such as, fetal distress, preterm delivery, low birth weight, as well as risk of type 2 diabetes to the mother (1). Research links vitamin D receptor (VDR), which is also found in islet beta cells, to insulin secretion, thus possibly helping manage GDM (1). A recent study was conducted to further evaluate various doses of vitamin D and