The Background Physiology And Pathophysiology Of Type II Diabetes And Cardiovascular Disease

Type II Diabetes, also known as diabetes mellitus, is also called non-insulin-dependent diabetes or aadult onset diabetes. It is a medical disorder that, due to a number of factors codependent with the modern world, is characterized by higher than normal blood glucose levels that play havoc with insulin deficiency and resistance. Insulin resistance means that cells do not respond appropriately when there is free insulin in the blood system. Essentially, they body is reacting to an improper balance of sugars and insulin. Because obesity is often present, research suggests that even thought the mechanisms controling glucose and insulin are unclear, the adopose tissue likely

Type 1 diabetes is well known disease, some of us or someone we know are the victim of this chronic illness. There are controversial explanation such as, genetic susceptibility and in contrary, environmental factors that are viral infection, prenatal and neonatal influence, nitrate in drinking water, (Norris et al, 2003) early exposure to cow’s milk towards why the immune system destroy the insulin producing beta cell. In this essay, I will be discussing about the pathophysiology of type 1 diabetes and how it affect the homeostasis of our normal functioning body. In subject to Carol, I will be explaining the signs and symptoms of the illness and also the possible effects to her developing foetus and herself.

T1DM is a chronic condition that during which the immune system is activated to deconstruct the insulin the beta- cells in the Langerhans in pancreas produced.It cannot be prevented by modifiable lifestyle factors nor can it be cured because the exact cause of this auto- immune process is not known (Diabetes Australia, 2015). Early symptoms of T1DM includes hyperglycemia, polydypsia, polyuria, fatigue, dizziness, recurrent skin infections,headaches. Some late symptoms may be severe dehydration, frequent

Type 2 diabetes mellitus (T2D) is the most common form of diabetes (American Diabetes Association, 2012). T2D is so prevalent that it is estimated to be the fifth most common cause of death worldwide (Yates, Jarvis, Troughton, and JaneDavies, 2009, p. 1). T2D manifests when the body is unable to metabolize glucose properly, resulting in elevated blood sugar, debilitating fatigue, and other serious complications such as distal limb amputations, kidney failure, and blindness. The generally accepted causes of T2D include diet, sedentary lifestyle, and obesity.

• Physiology - Noun 1. The branch of biology that deals with the normal functions of living organisms and their parts. 2. The way in which a living organism or bodily part functions.

     Diabetes mellitus is a group of metabolic disorders characterized by inadequate insulin secretion by the pancreas or cellular destruction leading to an insulin deficiency. Depending on the cause of the insulin shortage, diabetes can be subcategorized into type I and type II. Type I diabetes (T1DM) is usually mediated by the destruction of b-cells in the pancreas resulting in decreased insulin production and secretion. Type II diabetes (T2DM) is the failure of these b-cells to secrete adequate amounts of insulin to compensate for insulin resistance and increased gluconeogenesis combined with an overall resistance to the insulin action (8., 1997). T2DM accounts

Insulin resistance is the first physiological change occurring in type two diabetes. In these type two diabetic patients, insulin is unable to move glucose into liver, kidney and muscle cells although insulin is able to attach properly to the cell surface receptors. In order to rectify this, most patients with type two diabetes start secreting normal to very high levels of insulin, which can initially overcome this resistance. After a while, the pancreas cannot keep up with this high insulin production and the cells become resistant to glucose intake. Persistent hyperglycemia or high blood glucose levels are not desirable since this causes damage to the beta cells of the pancreas that produces the insulin hormone. This damage to beta cells further hampers insulin synthesis and patients at this stage are categorized as full-blown diabetic. Such patients consistently show a hyperglycemia state even after hours of fasting ( Hinkle & Cheever,

Diabetes mellitus type 2 is an endocrine disorder that causes impaired use of carbohydrates while enhancing the use of proteins and lipids. This is called insulin resistance, in which the pancreas cannot make enough insulin to keep blood glucose levels normal, or the body is unable to use what is produced. The impairment causes blood glucose level to rise higher than normal. There is no cure for type 2 diabetes mellitus and it is life threatening when left untreated. Signs and symptoms of this disorder include vision changes, increased thirst, increased hunger, increased frequency of urination, stomach pain, nausea and vomiting, erectile dysfunction, and absences of mentruation. These can occur abruptly, or over a long period of time.

Type-II diabetes mellitus (also referred to as simply type-II diabetes or T2DM) is a chronic disease in which individuals are unable to produce adequate amounts of insulin from the pancreas, or who are unable to use any

Diabetes mellitus Type 2 also known as adult onset diabetes is the most common form of diabetes today. Type 2 Diabetes can be caused by a lack of insulin created or the cells in the body being insulin resistant. Insulin is needed for the body to be able to use glucose (sugar) as energy for the cells. Insulin resistance causes your body to create more insulin than you need in your body to compensate for the insulin your cells are not able to use. Over time the pancreas fails to make extra insulin. This is why Type 2 Diabetes is seen more in people over 65, according to the American Diabetes Association. Without a healthy body, the pancreas will be unable to produce extra insulin to account for the transferring of an adequate amount of blood glucose to the cells. With a low glucose level in the cells, the cells fail to fuel the body which can lead to cells being energy starved. A high glucose level in the blood can lead to damages to the heart, eyes, kidneys and nerves over time. Even though Type 2

Type II Non-insulin dependent diabetes is the most common. It often occurs in older adults, patients who are overweight, and patient with metabolic disorders. It can happen at any age though. The tissues in the body have built some resistance to insulin. The insulin levels in these patients can vary from low to high and can also be normal. You might be at risk of developing Non-insulin dependent diabetes if you have a family history diabetes, being obese, not exercising enough, and your age. Rosdahl (2012) notes that Non-insulin dependent diabetes patients do not need insulin for life but May or may not need it to help control their insulin levels. Most patients

Diabetes mellitus (DM) is a condition in the body that is related to a faulty metabolism. It means that the body’s metabolism is not functioning properly, which leads to adverse effects in the health. The food we ingest, gets broken down into blood sugar (glucose), which is what fuels our body in the form of energy. This converted glucose needs to enter our cells so that it can be used for energy and growth. And in order for the glucose to enter our cells, there needs to be insulin present, which the beta cells of the pancreas is responsible for producing. This hormone is responsible for maintaining glucose level in the blood. It allows the body cells to use glucose as a main

Diabetes mellitus (or diabetes) is a threatening disease which occurs as a result of loss of uptake of glucose by cell thus increasing its concentration in the blood(Walker and Colledge 2013). Glucose, normally referred to as blood sugar is mainly present in blood and acts to provide energy to the body. It can be thought of a syndrome of hyperglycemic condition where disorders in metabolism occur(Tierney, Saint et al. 2002). It can be termed as metabolic sickness portrayed by hyperglycemia which result due to deformities in insulin discharge, its activity or both of these(Alberti and Zimmet 1998, American Diabetes 2010). The chronic state of disease is that in which hyperglycemia can lead to disorders affecting organs such as kidneys, heart ,eyes and blood vessels etc.(American Diabetes 2010).Diabetes occurs usually when the release of

Diabetes mellitus is a group of diseases which affect the amount of glucose in the blood. The high blood glucose levels are caused by the body not being able to produce enough insulin to meet its metabolic needs. Insulin is a hormone released from the pancreas which controls the amount of glucose in the blood. When there is too much glucose in the blood insulin will be released which will move glucose into the cells. Once in the cells the glucose is used as an energy source or it is stored as glycogen. There are two diseases which fall under diabetes mellitus which are type I and type II. In type I diabetes the body cannot produce insulin due to the destruction of the pancreatic beta cells. Type II diabetes is

fats and proteins increases. Type 2 DM patients have characteristics of age usually greater than 30years, they are obese and though they have plasma insulin normal to high, they have reduced insulin sensitivity with high glucose, high glucagon and so they require weight loss and anti-diabetics like insulin or oral hypoglycemics. Clinical characteristics of type 2 DM are shown in table 1.