The Causes Of Bacterial Meningitis Worldwide

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Neisseria meningitidis has been around for hundreds of years and has been one of the major causes of bacterial meningitis worldwide. This non endospore forming diplococcus, aerobic, gram negative bacterial pathogen is exclusive only to humans and is a challenge worldwide. Over 500,000 cases occur each year which makes it in the top ten infectious cause of death worldwide [7]. Physical and mental side effects are often a permanent outcome for patient that survive Neisseria meningitidis. Neisseria meningitidis is located in the back of the nose or throat in around 1 to 10, which show no signs of disease transient microbiota. When a patient that carries this bacterium, but doesn 't show any signs, is know as a asymptomatic carrier. When traveling to Hajj, a pilgrimage to Mecca, a vaccination must be proven. Medical conditions such as myeloma, alcoholism, renal disease, chronic lymphocytic leukemia and splenectomy increases congenital deficiencies of immunoglobulins, which predisposes the patient to being susceptible to Neisseria meningitidis. Large outbreaks of this bacterium can occur when the combination of clonal and increased transmission occur. Abnormalities in bactericidal activity of human sera is another characteristic in a humans that make them more susceptible to the bacterium [7]. To predispose a patient to the bacterium is the absence of bactericidal antibodies (an antibody that kills the bacterial agent), the presence of blocking antibodies (an antibody that
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