The Causes and Detrimental Effects of Parkinson's Disease

Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016).

Parkinson 's disease is a progressive neurologic degenerative disease of the Central Nervous system. The brain produces Dopamine and Norepinephrine, which are chemicals needed for smooth muscle movement and coordination, heart rate, and blood pressure. Dopamine and Norepinephrine are released by basal ganglions that are produced in a bundle of nerve cells in the brainstem called substantia nigra. In Parkinson 's patients, the substantia nigra are destroyed and neither of the chemicals can be released into the body. (3) The decrease in Norepinephrine causes heart arrhythmia and low blood pressure, causing the person to get dizzy upon standing or tire easily. The lack of Dopamine, the smooth muscle movement and coordination controller is now gone, or significantly decreased, resulting in the first signs of Parkinson’s disease, pill-rolling, a one handed tremor and a decreased appetite. (2)

Parkinson’s disease is a “neurodegenerative disorder of the basal nuclei due to insufficient secretion of the neurotransmitter dopamine” (Marieb & Hoehn, 2013, p. G-17). The cause of Parkinson’s disease is unknown, but many factors play a role in the development of Parkinson’s disease. One factor that has been found in an individual who has Parkinson’s disease causes over activity of targeted dopamine-deprived basal nuclei. This over activity is caused by the breakdown of neurons that release dopamine in the substantia nigra (Marieb & Hoehn, 2013). Another factor that is present in a person who has Parkinson’s disease, is the presence of lewy bodies in the brain stem ("What is lbd?," 2014). Lewy bodies are unusual

The major component shared by both Parkinson’s disease and dementia is the functioning of neurons, with a then understandable association. Dementia is caused by neuron demise or diminished capacity of communication with other cells, while Parkinson’s disease, neurons in the basal ganglia experience deterioration that disrupts the normal neurotransmitter dopamine balance where neurons waste and die. With this shared neuron deterioration, the prevalence of dementia associated with Parkinson’s disease is clearly understood. One-third of all patients with Parkinson’s disease will display dementia (LeMone, Burke, & Bauldoff, 2011) with indicators identical to Alzheimer’s form of dementia.

In Parkinson's Disease and Huntington's disease the nigra-striatum neural communication assemblage is severely hampered. PD results from a depletion in the amount of dopamine produced by the brain. At the onset of the disease, dopamine-secreting cells of the substania nigra, either because of genetic factors or environmental toxins, experience mass cell death. Thus, the nigra cells are unable to form synapses through which they secrete and relay dopamine to the striatum in a neural circuit within the basal ganglia (18).

Parkinson’s disease is caused by the destruction of dopamine-producing nerve cells in the midbrain (Substantia nigra). These nerve cells are used to coordinate smooth and regular body movement. In the absence of these cells, people often experience tremors (involuntary shaking or

Parkinson’s disease “is described as a common disorder of the brain caused by a progressive deterioration of the areas that produce the neurotransmitter dopamine” (Fischer, 1999). It affects the nervous system, more specifically it affects the nerve cells in your brain that secrete dopamine. Dopamine is a chemical that is responsible for the movement and coordination of the musculoskeletal system.

PD is the second most common neurodegenerative disease featured pathologically by the progressive loss of dopaminergic neurons in the substantia nigra. The typical symptoms of PD include slowness of movements (bradykinesia), muscle stiffness (rigidity), tremor, and balance disturbance. Etiopathologically, PD is considered to be caused by the significant loss of dopaminergic neurons in the substantia nigra pars compacta and the subsequent dopamine depletion at the striatum. To date, there are only symptomatic treatments available for PD, particularly in the early stages of the disease. No therapy has been found that can cure or halt the progression of the disease.

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).

Parkinson’s disease (PD) is a motor system disorder that affects the brain’s dopaminergic system, which transmits the neurotransmitter dopamine through dopaminergic pathways. The substantia nigra is a darkly pigmented structure that projects one of the body’s three distinct dopaminergic pathways. The substantia nigra links to the globus pallidus of the basal ganglia, which consists of several subcortical structures (including the substantia nigra). The basal ganglia are connected to the motor regions of the cortex through the thalamus, and therefore, it is involved with controlling the starting or initiating of movement. When there is a decrease in the production of dopamine within the substantia nigra, and approximately 50-80% of the dopamine

Parkinson’s Disease is a very common disorder these days. Over 10 million people live daily with Parkinson worldwide. Parkinson’s Disease was named after an English surgeon James Parkinson who wrote a detailed description essay called Shaking Palsy in 1817. The average age for Parkinson’s Disease is between 45 to 70 years old but you can also have juvenile or young onset as well. Most common symptoms of Parkinson are tremors, bradykinesia or akinesia, or rigidity or stiffness, and balance disorder. Parkinson’s Disease doesn’t have a cure and the cause is unknown it could be a number of things genetics, environmental triggers, age, or gender. Parkinson’s Disease happens because the dopaminergic neuron dies and

Parkinson’s Disease and Action of Drugs on Movement Introduction: Parkinson’s disease is a neurological disorder that seriously impairs motor function, with people afflicted with this condition exhibiting akinesia, muscle rigidity and having a tremor at rest. It is accepted that the loss of motor function is brought upon by the progressive degeneration of nigrostriatal dopamine neurons, which leads to a corresponding loss of dopamine in the caudate/putamen part of the basal ganglia, which is accepted as the main receiving area in motor circuits. Information coming to it from the cortex and thalamus is processed and channeled to the pallidum and to the substantia nigra reticular. There are two

The journal article, The impact of Parkinson’s disease on vocal-prosodic communication from the perspective of the listeners, written by Marc D. Pell, Henry S. Cheang, and Carol L. Leonard in 2005, discusses the impact of dysprosody on people with idiopathic Parkinson’s disease, (PD) from the viewpoint of the listeners. Both the experimental and control groups were recorded when completing speech tasks. The aim of this article was to study how listeners perceive the speech of persons with PD, and if they are able to differentiate the emotions of the speakers with Parkinson’s disease compared to the healthy adult speakers.

o When dopamine producing cells are reduced by 80%, the physical symptoms of Parkinson’s present themselves

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,