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The Central Nervous System ( Cns ) Development

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Introduction
Central nervous system (CNS) development is complex, as genetic and environmental factors influence rapidly occurring processes throughout prenatal life. During CNS development, phylogenetically primordial regions of the brain develop first, followed by more complex structures. When this procedure is disrupted, teratogenic outcomes are often observed, leading to serious mental or motor dysfunctions if not fetal death (Martin and Dombrowski, 2008). Thus the prenatal CNS is vulnerable to environmental factors, such as folate deficiency (FD), during rapidly developing periods, producing detrimental outcomes, for example neural tube defects (NTD).

Folate
Folate is a necessary vitamin part of the B complex group, not synthesized de novo, but consumed through foods such as leafy green vegetables (Djukic, 2007). In the developing fetus, folate transport across the placenta is regulated by reduced-folate-carriers and folate receptor proteins, which allow large folate requirements needed for high cell proliferation rates to be met. Both also show an increased pattern of expression during neural tube closure, indicating that folate has a crucial role in CNS development (Djukic, 2007). Fleming and Copp (1998) demonstrated this by successfully treating mice embryos predisposed to neural tube defects using folic acid supplements. The mechanism of its action on neural tube development is currently still not fully understood. However it is known that folate is crucial for

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