The Congential Vericella Syndrome (CVS) Essay

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In most cases, a varicella zoster infection will lead to a case of chicken pox in children and in adults who are susceptible to the disease and not vaccinated but if a woman is infected during the early stages of pregnancy the fetus could be born with birth defects. Congenital Varicella Syndrome (CVS) is a rare but serious disease that affects about 2% of pregnancies exposed to the virus in the first trimester. The disease leads to low birth weight, skin and/or extremity abnormalities, and in very extreme cases defects of the brain, eyes, or other organs. The range of symptoms depends on what stage of fetal development the mother becomes infected. The first 20 weeks of gestation are crucial for normal fetal development, during this …show more content…
In most cases, a varicella zoster infection will lead to a case of chicken pox in children and in adults who are susceptible to the disease and not vaccinated but if a woman is infected during the early stages of pregnancy the fetus could be born with birth defects. Congenital Varicella Syndrome (CVS) is a rare but serious disease that affects about 2% of pregnancies exposed to the virus in the first trimester. The disease leads to low birth weight, skin and/or extremity abnormalities, and in very extreme cases defects of the brain, eyes, or other organs. The range of symptoms depends on what stage of fetal development the mother becomes infected. The first 20 weeks of gestation are crucial for normal fetal development, during this period, the babies cells are rapidly multiplying and differentiating to form bones, tissues, organs, and skin. If the mother becomes infected with varicella-zoster during the second or third trimester the fetal immune system is more able to fight off the infection. Infection during the last 2 weeks of the pregnancy may lead to the baby receiving maternal anti-VZV antibodies through the cord blood but if the infection occurs less than a week from giving birth the baby may develop neonatal chickenpox, which can be life-threatening with very severe symptoms including hepatitis, encephalitis, and pneumonia. The smallest of the human herpesviruses, varicella-zoster virus (VZV), has a linear double-stranded DNA genome core surrounded by an

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