The Consumption Of Fats Plays A Key Role On The Development Of The Fetus

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During pregnancy, the consumption of fats plays a key role in the development of the fetus. A dietary fat is an essential nutrient that helps the body function by providing protection, fuel and absorption for cells, tissues and organs. The fats consumed are Triglycerides and the mechanism behind this process is for lipoprotein lipase (LPL) to break the triglycerides into smaller components. They mostly contain fatty acids, cholesterol, fat-soluble vitamins and other lipids that will be delivered to target tissues for performing activities, or stored as fat if not directly used. The increased consumption of triglycerides can raise blood lipid levels such as low-density lipoprotein (LDL) that promotes the risk of developing cardiovascular…show more content…
Over time, collected data from the third trimester (G130) of all pregnancies resulted in a significant decrease in blood volume flow of the HFD maternal and the placental portion of the fetus.
The authors revealed that A, Uterine artery (Uta) PI is 0.74 in a representative control animal. B, The Uta PI is 1.17 in a representative HFD-S animal with a Doppler waveform that demonstrates decreased diastolic flow consistent with increased vascular impedance when compared with A. (1) The study is suggesting that the accumulation of fat molecules in the placenta restricted the blood to flow through. Moreover, Insufficient oxygen and nutrients from the placental can interfere with the growth of the fetus.
The immunohistochemistry, confirmed no TLR4 staining in the chorionic villous stroma in control placentas. Conversely, there were increased levels of TLR4 staining in chorionic villous stroma and syncytiotrophoblast in HFD placentas. (1) The TLR4 is a protein pathway responsible for activating the fetus immune system by providing a supply of nutrients and protection. However, constant irritation of circulating blood lipids within this pathway has changed the function of the protein, becoming vulnerable to the hazardous environment. At the same time, the TLR4 in both parts of the placenta of the mother and fetus has developed inflammation. Although this study was on non-human primates, we can still see similarities when comparing structures of the human uterus. Critically,

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