The Current Pressurized Oxygen Tension Based Indices Response

1290 WordsJan 27, 20166 Pages
In this thesis, I have attempted to further explore the nature of the current utilised oxygen-tension-based indices response, with a view to its use as a tool to assess the pulmonary oxygenation in critically ill patients. Furthermore, this thesis developed a new index to assess pulmonary oxygenation. This topic was explored with external pulmonary factors to quantify oxygenation defect through a maze of mathematics, different diseases, and pathophysiology. There was one or two ways that could lead us to the answer and many dead end routes. Ultimately, the research produced an equation that was more robust than the PaO2/FiO2 ratio in terms of less variation. The first chapter described two different types of oxygen indices and its use. The second chapter described the medical simulator in general and the Nottingham Physiology Simulator (NPS) in particular. In chapter three, we examined the variation of certain oxygen indices with changes in the following external physiological factors (FIO2, Hb, RQ, and VO2) without changing the pulmonary configuration status. This investigation was done with ARDS simulated patients using a validated NPS model. The study demonstrates that the external physiological factors induced a remarkable variation in comparing to oxygen indices, and the use of each index depends on the type of the external physiological factors. However, we conclude that clinicians should be aware of using the best index according to patient’s status. Accordingly,

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