Marijuana, Cannabis Sativa, has been used for centuries for its medicinal and euphorant properties, and its fibers, to make hemp cloth and paper. Medicinally, between 1850 and 1942, it was prescribed in the United States Pharmacopeia as a remedy for a variety of ailments including gout, tetanus, depression, and cramps (Farthing 1992). Today, it is used for reducing intraocular pressure due to glaucoma, as an antiemetic to relieve nausea associated with chemotherapy, and as an appetite stimulant for AIDS patients. Recreationally, it is the most widely used illicit drug, especially among adolescents.
The main psychoactive component of marijuana is (9-tetrahydrocannabinol (THC). Other prominent cannabinoids include cannabidiol,
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In this paper, my objective is to determine potential chronic effects of marijuana on memory. I do this by selectively reviewing studies on this topic and attempt to integrate the findings, which range from neurobiological standpoints to more general effects on cognitive behavior.
In earlier attempts of finding the cannabinoid receptor, using THC as the ligand proved difficult because of its lipid solubility which cause non-specific, high affinity binding. In Herkenham et al. (1990), they localize cannabinoid receptors (CB1) throughout the brain by using synthesized, radiolabeled CP 55,940, structurally similar to THC, but less hydrophobic and more potent as a cannabinoid receptor ligand. They find high density binding in the cerebellum and basal ganglia (which regulates time perception and coordinated movement), the cerebral cortex (perception and reasoning) and the hippocampus, which is associated with memory. This correlates with marijuana's distortion of these cognitive functions, including memory. The hippocampus, located in the inferior medial temporal lobe, has been shown to be involved with memory through studies with brain-damaged patients such as HM, who, in the extreme case, resulted in having anterograde amnesia (inability to form new long-term memories) due to the removal of the bilateral hippocampus (Gazzaniga et
THC disrupts the nerve cells in the part of the brain where memories are formed. This makes it hard for the user to recall recent events (such as what happened a few minutes ago), and so it is hard to learn while high. A working short-term memory is required for learning and performing tasks that call for more than one or two steps. Some studies show that when people have smoked large amounts of marijuana for many years, the drug takes its toll on mental functions. Among a group of long-time heavy marijuana users in Costa Rica, researchers found that the people had great trouble when asked to recall a short list of words (a standard test of memory). People in that study group also found it very hard to focus their attention on the tests
People might think smoking marijuana is cool. They might try it without knowing what it is or what affects is has on you. Once someone smokes it for the first time, they might keep doing it again and again and they could get hooked on it for life. People who use marijuana usually never use any other type of illegal drugs, but more than seven thousand five hundred people get arrested for using marijuana every year. There is a wide variety of marijuana, but they are all based off of two marijuana plants, Indica and Sativa. Marijuana is very popular in America, and all over the world. Marijuana affects the body, it can be used as medicine, and marijuana can be addictive.
Medicinal Value Marijuana, in its natural form, is one of the safest therapeutically active substances known. No one has ever died from an overdose. It is also extremely versatile. Four of its general therapeutic applications include: relief from nausea and increase of appetite; reduction of intraocular ("within the eye")
Marijuana is a good source of fiber and has been used for decades. Marijuana was first used in China as a medical treatment. It was used in North America for fiber. Marijuana was legal for medical uses from 1860 until 1942. It is known as a gateway drug. Many people believe that “marijuana is a powerful addictive drug that would lead users into narcotics” (“infoplease”). It is a proven fact that marijuana is a physical addiction not a mental addiction. Many people believe that marijuana leads
Marijuana has many medical purposes also. The cannabis extract was available as a medicine legally in this country until 1937, and was sold as a nerve tonic-but mankind has been using cannabis medicines much longer than that. Marijuana appears in almost every known book of medicine written by ancient scholars and wise men. It is usually ranked among the top medicines, called 'panaceas', a word which means 'cure-all'. The list of diseases which cannabis can be used for includes: multiple sclerosis, cancer treatment, AIDS (and AIDS treatment), glaucoma, depression, epilepsy, migraine headaches, asthma, pruritis, sclerodoma, severe pain, and dystonia. This list does not even consider the other medicines which can be made out of marijuana-these are just some of the illnesses for which people smoke or eat whole marijuana today. There are over 60 chemicals in marijuana which may have medical uses. It is relatively easy to extract these into food or beverage, or into some sort of lotion, using butter, fat, oil, or alcohol. One chemical, cannabinol, may be useful to help people who cannot sleep.
Marijuana has been used in the treatment of AIDS, cancer, glaucoma, multiple sclerosis, and chronic pain ("Medical Cannabis."). Researchers have been trying to explain the negative effects that marijuana can have on the central nervous system and how it hinders memory as well. The constant reports of short-term memory loss by heavy marijuana users brings up the question, is it the most common long term effect of marijuana use? Although it is said that marijuana has many effects such as exhaustion, increased appetite, offset sense of time, and bloodshot eyes, short-term memory loss is the symptom most frequently linked with the use or ingestion of marijuana. But why? Why does using marijuana have any impact on a person’s memory at all? Countless scientists have been working tirelessly to find an answer for this question. The active ingredient in marijuana, THC, is known to attach itself to areas of the brain linked to memory. When the scientists injected lab animals with THC at Rutgers University, they found that they acted as though there was no rhythm to their thought. It affected the hippocampal circuits in the brain to produce animals that were acting normal but in a delayed or offset manor.
Marijuana has been around for centuries. It comes from the species of plant Cannabis Sativa, and is used for things other that its renowned drug form, such as rope, clothing, medicines, and oils. Other common names for it include
However, there is accumulating evidence of the psychological consequences of using marijuana. Many chronic marijuana smokers have a psychosis that is now medically deemed as, “A-motivational Syndrome” (Chopra 38). A psychosis is a condition where a person experiences some loss of contact with reality. A person with a psychosis can experience any or more of the following symptoms: auditory hallucinations (hearing voices that aren't really there), visual hallucinations (seeing things which aren't there), delusions (believing things that aren't true), jumbled thoughts and strange behavior. Patients with A-motivational Syndrome are left with the well-recognized and permanent symptoms of memory loss, apathy and loss of motivation (Chopra 38). After marijuana started to be widely used approximately 20 years ago, for permanent damage to occur it was felt by some that marijuana had to be heavily used over at least three years. However, there is accumulating evidence that smaller amounts will do damage. It is logical that to get the permanent “ A-motivational Syndrome”, small amounts of damage have to accumulate incrementally (Chopra 40). Although many marijuana connoisseurs of today may totally deny that that the use of this drug has lasting effects on the brain, research findings clearly indicate that long-term use of marijuana produces changes in the brain similar to those seen after long-term use of other major drugs of abuse (Erickson 89).
1. Attention, memory and learning are impaired among heavy marijuana users, even after users discontinued its use for at least 24 hours. Heavy marijuana use is associated with residual neuropsychological effects even after a day of supervised abstinence from the drug. Heavy users displayed significantly greater impairment than light users on attention/executive functions, as evidenced particularly by greater preservations on card sorting and reduced learning of word lists. These differences remained after controlling for potential confounding variables, such as estimated levels of premorbid cognitive functioning, and for use of alcohol and other substances in the two groups. However, the question remains open
One region of the brain that contains a lot of THC receptors is the hippocampus, which processes memory. When THC attaches to receptors in the hippocampus, it weakens short-term memory. The hippocampus also communicates with other brain regions that process new information into long-term memory. In the brain, under the influence of marijuana, new information may never register, and may be lost from memory.
There are several chemical processes involved when marijuana enters the brain, and it is important to know what these processes are in order to better understand marijuana’s adverse effects on memory. Though there are many chemicals in marijuana, there are only two main ingredients linked directly to the cognitive effects of the drug. The principal psychoactive component in cannabis is delta 9-tetrahydrocannabinol (Δ9-THC), it is linked to the adverse effects of the drug on various cognitive functions, including memory (Schoeler and Bhattacharyya, 2013). The second
Marijuana has been used by people over many centuries for medical uses. It is a natural pain killer used today as a recreational drug by people all over the world. According to Noel Merino in, “Introduction to Gateway Drugs: Opposing Viewpoints”, “a drug is something other than food intended to affect the structure or function of the body”. Marijuana is a very controversial drug and has been outlawed in many countries for its affect on the function of the body. “Effects may involve hallucinations, impaired judgment, and mood swings.” Describes the effects of marijuana in “Marijuana” Current Issues Macmillian social science library. During the past century Marijuana has been legal, made illegal, strictly enforced, decriminalized,
The effects of marijuana include, “Euphoria, relaxed inhibitions, increased appetite, disorientation” (Abadinsky, 2014, p. 111). Marijuana is typically smoked by users by using blunts, bongs, or pipes, and inhaled into the lungs (Abadinsky, 2014). The high will occur within ten minutes, and become stronger within 30 minutes (Abadinsky, 2014). When someone smokes marijuana, he or she will obtain a high for about three hours (Abadinsky, 2014). There are cannabinoid receptors in the brain that signify that our central nervous system has “natural brain compounds similar to THC that play a role in numerous physiological processes including appetite, memory, and pain” (Abadinsky, 2014, p. 111). Meaning, when marijuana or THC enters the body, the
Cannabis, formally known as marijuana is a drug obtained from the tops, stems and leaves of the hemp plant cannabis. The drug is one of the most commonly used drugs in the world. Only substances like caffeine, nicotine and alcohol are used more (“Marijuana” 1). In the U. S. where some use it to feel “high” or get an escape from reality. The drug is referred to in many ways; weed, grass, pot, and or reefer are some common names used to describe the drug (“Marijuana” 1). Like most drugs, marijuana has a very long history. People have been using the plant around the world for thousands of years. The oldest record of the marijuana plant dates back to 2727 B. C. in China where the plant was used as a medical herb for treating conditions like rheumatism, gout, malaria and even absent-mindedness (“Cannabis, Coca, & Poopy: Nature’s Addictive Plants” 1). Slowly, the plant started spreading around the world. By 1545, cannabis was starting to appear throughout the western worlds. Being introduced to South America by the Spanish to be used as fiber. The crop also had many other common uses around the world. In North America, cannabis was often used to make paper, ropes, clothing and other materials (“The Origins of Cannabis” 1).
Many regions of the brain contain cannabinoid receptors, of which anandamide molecules, concerned with regulating mood, appetite and emotions, naturally bind to. Cannabis contains an active ingredient known as ‘delta-9-tetrahydrocannabonic’ (THC), and when smoked or eaten, the THC imitates the activity of anandamide by binding to cannabinoid receptors on nerve cells, and therefore influences