The Disease Of Cystic Fibrosis

Cystic fibrosis is an existence restricting autosomal recessive disorder that influences 70,000 people around the world. The condition is known to affect principally those of European descent, though cystic fibrosis has been accounted for in all races and ethnicities. [12] Unusually viscous emissions in the airway of the lungs and in ducts of the pancreas in people with cystic fibrosis cause hindrances that prompt aggravation, tissue harm and destruction of both organ systems. Studies show that Cystic Fibrosis is more prominent in White Americans than African Americans, and Hispanics. A large number of Americans are carriers of this mutated Cystic Fibrosis gene, however if an individual is affected they must acquire two of these genes keeping

Cystic Fibrosis is a life threatening condition that causes severe damage to the lungs and digestive system. Developing this condition can change a person's entire life. Depending on the severity of the condition a person can be affected by mild symptoms such as shortness of breath, all the way to severe symptoms such as rectal prolapse, or even death. Screening is done on infants in all 50 states; therefore if a child has inherited Cystic Fibrosis it will be known in the first months of life. As professional staff members of a nursing community it will be necessary to help prepare the child and the family for the life of Cystic Fibrosis.

Those with cystic fibrosis often have a thick, sticky mucus that blocks the bronchi and alveoli which allow air in and out of the lungs. This mucus may cause:

Cystic fibrosis generally affects mainly the lungs, pancreas, liver, intestines, sinuses, and the sex organs. People who have cystic fibrosis can have a variety of symptoms. Some people may only go through a few of them. Though, other people may go though more symptoms that later on can become very severe. One of the earliest symptom of cystic fibrosis that can be noticed beforehand is that the skin of a baby will have a salty taste when kissed. The rest of the symptoms happen later overtime as they start growing up. They affect the respiratory, digestive and reproductive system. One of the signs of cystic fibrosis in the respiratory system is the thick, sticky mucus that blocks the airways. Which causes bacteria to start growing and other infections too. This can also lead to frequent coughing, wheezing noises, and lung infections. Other problems may occur like sinusitis, bronchitis, and pneumonia, these can cause serious damage to the lungs. Cystic fibrosis affects the digestive system in many ways

Cystic fibrosis is an autosomal recessive disorder due to a defect in the cystic fibrosis transmembrane receptor, protein buildup causing thick mucus and secretions in lungs, pancreas, liver & intestines. The clinical manifestations include respiratory with recurrent lung infections (S. aureus, Pseudomonas), productive cough, dyspnea, chest pain, wheezing, the gastrointestinal with meconium ileus at birth, later failure to thrive, chronic diarrhea, systemic with infertility and heart exhaustion. Obstructive Lung disease, pancreatic insufficiency, elevated chloride in sweat diagnostic will lead to a bronchiectasis, infertility, growth delays and Meconium Ileus (MC initial presentation)

Cystic fibrosis is a genetic disease that affects the respiratory system, digestive/endocrine, and reproductive system. A defective gene produces an abnormally thick mucus in the trachea and causes a blockage in the trachea, damages lung, and resulting in failure of the respiratory system. The mucus also interferes with the pancreas, which it prevents the secretion of digestive enzymes that help dissolve food, causing difficulty in absorbing nutrients. CF causes infertility, particularly in men. However, they are not sterile, therefore they can have children with assisted reproductive techniques. In most cases, many of them are diagnosed with CF before the age of 2 because the newborns are screened immediately after birth. On the other hand,

Cystic fibrosis is a genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator protein, which results in a defective chloride channels. Chloride is part of salt that helps transportation of water needed for thin, free flowing mucus. The main characterization of cystic fibrosis is thick, sticky mucus in the lungs, making breathing difficult and allowing pathogens to invade (Ratjen and Döring 2003). Airway mucus creates an iron limiting environment to prevent bacterial growth. However, Pseudomonas aeruginosa is a bacteria able to resist this airway mucus. This proposes a question as to why people with cystic fibrosis are prone to infection when exposed to the same pathogen as any healthy individuals. Research has suggested defective mucus clearance and biofilm formation could contribute to prolonged Pseudomonas aeruginosa infection in people with cystic fibrosis (Gi et al. 2015). Also, targeting cystic fibrosis transmembrane conductance regulator proteins to allow chloride transportation has been proven to decrease mucus volume and Pseudomonas aeruginosa infected tissue (Rowe et al. 2014). The above information suggests increased mucus volume causes prolonged infection in the lungs of cystic fibrosis patients. This paper will describe cystic fibrosis and will focus on the unanswered question as to why cystic fibrosis patients experience chronic infection in their lungs.

I along with my group members chose the topic of Cystic Fibrosis. This is a disease that affects roughly 70,000 children worldwide. The first definitive description of Cystic Fibrosis was found in a child by Dr. Dorothy Anderson in 1938. There had been earlier sightings of the disease as far back as the late 1800s. It was denoted by the taste of salt on a Childs forehead when kissed by a parent. This idea was proven when Paul di Sant'Agnese proved that there was an increased salt excretion within patients who suffered from Cystic Fibrosis. With this break through the ability for doctors to be able to diagnose children became a lot easier and got rid of a large number of invasive tests that were not as effective. In 1985 the medical

Cystic Fibrosis, otherwise known as CF, is an inherited genetic disease that affects the lungs and digestive system. The disease causes a build-up of thick mucus in the lungs and other organs. Mucus clogs the airways in the lungs and “traps bacteria, leading to infections, extensive lung damage, and eventually, respiratory failure. In the pancreas, the mucus prevents the release of digestive enzymes that allow the body to break down food and absorb vital nutrients.” (#1)

intestines to help digest food [6]. People with Cystic Fibrosis have an increased risk of lung

Cystic fibrosis, an inherited disease of the secretory glands that affects the liver, pancreas, intestines, lungs, sinuses, and sex organs, affects about 30,000 Americans with 1,000 new cases diagnosed each year. Normal mucus is a watery, slick substance made by the tissues that keeps the inside of organs moist, preventing infection. People with cystic fibrosis have thick and sticky mucus that builds up in their lungs, blocking the airways. This buildup can cause serious lung diseases from bacteria growth that damages the lungs. This damage to the lungs can cause severe breathing problems which can lead to respiratory failure. Respiratory failure is the most common cause of death in people with cystic fibrosis. The thick and sticky mucus also can block the tubes that carry important enzymes from the pancreas to the small intestines that are needed to break down food and for your body to absorb the nutrients essential for one’s health.

Cystic Fibrosis is a defective gene that causes the mucus to become thick and build up in the lungs, pancreas, and other organs. This is a genetic disorder caused by a defective gene. People that have Cystic Fibrosis have two copies of the recessive Cystic Fibrosis gene (one from each parent). When parents are both carriers their children’s chances are 25% have Cystic Fibrosis, 50% will be a carrier, and 25% will not have Cystic Fibrosis. This causes lung infections and enzymes not to be digested so that nutrients and fats are not absorbed. People are at risk for having lung infection and it stops the absorption of food and key nutrients.

What is Cystic Fibrosis? Cystic Fibrosis is a disease inherited past down from many generations. Another name for cystic fibrosis is called clubbing there are many other name terminologies for cystic fibrosis. The name of the disease originates from the tough tissue, which scars inside the pancreas, first documented in the 1930’s. The pancreas is one the major organ attacked by a faulty chromosome no.7 where cystic fibrosis has been found. A cystic fibrosis patient can have the recessive gene and both of his or her parents can carry the gene but not affected by the gene. The disease attacks the external glands, which includes (lungs, perspiration glands, gastrointestinal system, and a man’s masculinity). Cystic fibrosis can cause several different

Cystic fibrosis is a pulmonary disease that affects around 30,000 individuals in the United States and 70,000 individuals worldwide.1 There are about 800 new cases diagnosed each year.1 Understanding of this condition has increased over the years as research has found it to affect more of the body’s systems than initially thought in the late 1900s.2 Due to the common complications it causes, cystic fibrosis is commonly generally classified as a pulmonary condition. However, it can cause dysfunction in many of the body’s systems including the hepatic system, the reproductive system, and the digestive/metabolic system, among others.1

Cystic fibrosis is inherited when a child receives two recessive genes for the disease. It is a disease that affects the secretory glands. Secretory glands are the glands in a person’s body that produces mucus and sweat. Mucus is a very important factor in a person’s body. Mucus lines multiple organs and protects them from infection while also keeping them from becoming too dry. When a person has cystic fibrosis, their mucus becomes thick and can block certain air ways in their body.