The Drug Target And Mechanism Of Action

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¬¬Currently cancer is a major cause of death in the world and it has a negative effect on the quality of life. In order to solve cancer problems, a variety of anticancer drugs produce that can treat or target carcinoma cells or discover tumor growth in human tissue (Colditz 2015). 5- Fluorouracil (5-FU) and Cetuximab are important examples of anticancer medicine; therefore, it is important to understand the drug target and mechanism of action of anticancer drugs. The main purpose of this essay is to explain the importance of the various mechanisms of action of cetuximab that ensure selectivity, efficacy and safety of Cetuximab compared to 5-FU. First, this essay will provide the history and description of 5-FU, then it will review and…show more content…
684). It is classified under antimetabolite agents that act as an analogue of the nucleotide and the pyrimidine antagonist (Nagaraju et al. 2014, p. 9980). 5-FU is highly toxic drug because it does not target only cancer cells, but also it interferes with normal cells (Golan & Tashjian 2008, p. 684). It works to inhibit the thymidylate synthase (TS) enzyme which symbolizes a significant “chemotherapeutic target for 5-FU” (Rudek et al. 2014, p. 260; Nagaraju et al. 2014, p. 9980). 5-FU mediates the reduction of TS in the intracellular pathway of “folate synthesis” because 5-FU action is reliant on “a competitive interaction” with the metabolism of folate (Rudek et al. 2014, pp. 5-314). More specifically, 5-fluorodeoxyuridine is an “active metabolite of 5-FU” which connects to the TS and terminates the production of thymidine and then immediately inhibiting the synthesis of DNA, which is an important stage in the growth of tumor cells, and stimulating apoptosis of cancer cells (Nagaraju et al. 2014, p. 9980; Golan & Tashjian 2008, p. 684). Note that the TS expression is an essential indicator of 5-FU response and sensitivity inside the body, and TS overexpression is lead to less anticancer effect and more resistance to 5-FU (Nagaraju et al. 2014, p. 9981). Although 5-FU has an anticancer activity, it is important to investigate another advanced anticancer drug that optimizes the outcome and improve the life of cancer patients. “Cetuximab is a
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