preview

The Economic Impact Of Amoebic Dysentery

Better Essays

There are no definitive metrics on the economic impact of amoebic dysentery. The disease mostly afflicts children in farming communities whose source of drinking water are streams, rivers and ponds. Knowledge of the economic cost of diarrheal diseases in the developing countries, on the other hand, offers rough estimates of the cost of amoebic dysentery. It worth mentioning that about 40% of the diarrheal diseases in the developing countries is attributable to amoebic dysentery according to a paper presented at the 28th African Health Sciences Congress, Mauritius, July, 2008. A study done at a Dr. George Mukhari Hospital, a tertiary level hospital, Gauteng, South Africa, estimates the total hospital and professional cost …show more content…

The latter, facilitated by specific lectin, adhere to and colonize the intestinal mucosa. The usual incubation period for Amoebiasis is about 10 days, but it can range from a few days to years. Patients present with cramping abdominal pain, bloody diarrhea, weight loss and fever. Fulminant colitis with systemic manifestations is rare. It presents with a sudden onset of severe bloody diarrhea, abdominal pain, and peritonitis with fever. young age, pregnancy, corticosteroid and impaired immunity are disposing factors. Life threatening intestinal perforation and toxic Megacolon may ensue, necessitating surgical intervention. Mortality from fulminant colitis may reach 50 %. Untreated intestinal Amoebiasis may proceed to chronic colitis presenting with recurring bloody diarrhea and abdominal discomfort. From the intestinal mucosa E. Histolytica trophozoites follow two paths. Some of them develop into cysts and get excreted in the feces to be recycled while others invade the intestinal mucosa and enter the bloodstream. Blood circulation enables the parasite to disseminate, invade and destroy the liver, lung, and other organs. Breakdown of tissues is a result of both cytolysis and apoptosis. The former is carried out by Amoebapores, a group of peptides secreted by the organism that are capable of creating holes in the cell walls. The parasite induces apoptosis through both a1 receptor pathway and the

Get Access