The Effect Of Cannabinoid Receptors On The Nervous System

The article written by Bill McCarberg, “Marijuana Can Help in Treatment Pain,” talks about the types of receptor systems of cannabinoids and the delivery routes. What are cannabinoids? Cannabinoids are active compounds that are found in cannabis. Cannabinoid receptor systems are found in

CBD has positive effects on reducing and managing psychotic, anxiety, and depressive-like behaviors. The mechanisms appear to be related to the CBD's benefit to provide enhanced neuroprotection and inhibition of excessive neuroinflammatory responses in neurodegenerative diseases and conditions. Common features involving neuroprotective mechanisms influenced by CBD—oxidative stress, immune mediators, and neurotrophic factors—are also important in conditions such as posttraumatic stress disorder (PTSD), postconcussion syndrome, depression, and anxiety. Many studies confirm that the function of the ECS is markedly increased in response to pathogenic events like trauma. This fact, supports the role of cannabinoids and their interactions with CB1

According to LEARN’s Prohbtd video, “CBD & THC are two cannabinoids of more than a hundred such chemical compounds found in the cannabis plant.” (LEARN) It is interesting to see more and more videos and other educational materials being introduced in regards to how beneficial cannabinoids are to the human body. Many people have conditions that would be benefitted by the continuous study of cannabinoids. ‘THC or Tetrahydrocannabinol is the feel good or high feeling portion of the plant and CBD or Cannabidiol is the medical part of the plant. The CBD is the part that researchers are trying to implement for use for individuals different medical conditions. We all have an endocannabinoid system that helps to keep us healthy and balanced biologically.’

The discovery of endocannabinoids led to the identification of an entire system in the human body, comprised of lipids, receptors, and enzymes. The endocannabinoid system is responsible for a host of physiological processes that rely on the interactivity of cannabinoids and their receptors. Since their discovery and cloning in the early ‘90s, the CB1 and CB2 receptors are still the only receptors that have been identified in the endocannabinoid system. The location of a

Consumption of cannabis, more commonly known as marijuana, is thought to cause psychological disorders. However, in some cases, cannabis has little to no causation evidence for the development of these disorders. As a result, it is still controversial whether cannabis truly increases the chances of developing these disorders.1 Consumption of marijuana is fatal to society. Society is under a great misconception that marijuana is a merely a recreational drug and its affects are temporary. Mainly adolescents seem to engage in its consumption, being unaware of the critical long term effects that can follow. Consumption of this drug, results with health issues that are irreversible and can persist through adult hood, causing permanent damage to one’s cognition and mental health. The main focus within this literacy paper will be -- can marijuana truly have causal links which relate to the occurrence of psychosis? This paper will discuss the effects that marijuana has on the neural pathways and will provide evidence for both “yes” and “no” sides regarding the causation of psychosis due to cannabis. Through the given evidences, conclusions will be drawn towards either the “yes” or the “no” side and this will answer the question.

In 1990, cannabinoid receptor type 1 (CB1) was discovered and is a part of a class of receptors called G protein-coupled receptors (GPCRs). These receptors sit within the cell membrane and are found to be located at the synapses of the central and peripheral nervous systems. When activated, they start a signaling domino effect within the cell, that ushers specific desired effects such as controlling movement and posture, perception

“Early exposure to cannabinoids in adolescent rodent decreases the reactivity of the brain dopamine reward centers later in adulthood”. Marijuana doesn’t cause people to use other substances. Marijuana increases the vulnerability for drug abuse and addiction to other substances later in life. Other substances such as Alcohol and nicotine can also have the same affects on the brain to use harder substances. There are other factors that come into play for further drug use; rather than just biological factors, such as a person’s social environment.

This essay has shown how governments support and control the use of cannabinoids as an effective treatment for diseases. In the first decades of the 20th-century, medical research of cannabinoids has reduced because of the legal restrictions imposed by governments. They fear of the spread of cannabinoids illegally, and governments do not believe the side benefits of cannabinoids that caused a lack of governments support. In addition, regulating, controlling and legalization the production of cannabinoids will make them safer. Governments should seriously consider legalizing cannabinoids that give a chance for scientists to advance important steps in research. It must be done more research and discoveries about cannabinoids. They treat many

Marijuana affects the Central Nervous System (CNS). THC resembles a natural transmitter in our brain called Anandamide. Cannabinoids are specialised neurotransmitters released by neurons. The neurons become temporarily unresponsive after firing to prevent them from overreacting of being too dominant. This allows the brain to function in a calm and controlled manner, however cannabinoids interrupt this approach in some parts of the brain instead, they remove the refractory period of neurons that are already active, which causes the person’s thoughts, imagination and perception to magnify itself. Therefore, their thoughts become profound and tend not to recall anything since they’re caught in the momentum of a particular idea and their neurons

Cannabinoids are the group of chemicals that bind to and activate the G-protein linked receptors CB1 and CB2. CB1 receptors are found in the central nervous system with the highest levels located in the hippocampus, basal ganglia, cortex, and cerebellum. CB1 receptors are also found in the peripheral nerve terminals and other tissues including: testes, uterus, spleen, eye, ilium, adipocytes, and vascular endothelium. Binding to the CB1 receptor results in the psychoactive effects of cannabinoids resulting in a feeling of euphoria. Activation of the CB1 receptors results in inward potassium channel conductance and decreases both N type and P/Q type calcium channels. Activation of these receptors also results in decreased endogenous cannabinoids.

The overall focus of my research is to better understand the roles of fatty acid binding proteins (FABPs), specifically epidermal-FABP (FAPB5) and brain-FABP (FABP7) and their influence on addictive behavior. Central to the endocannabinoid system is the cannabinoid type 1 receptor (CB1R), which is expressed ubiquitously throughout the brain [1]. Within the mesolimbic system, activation of CB1Rs modulate the release of dopamine. This is done by CB1’s ability to inhibit GABA and glutamate projections onto ventral tegmental area (VTA) dopamine neurons [3]. CB1R agonists have been shown to increase dopamine levels in NAc, thereby increasing the reinforcing effects of drugs of abuse [4]. In contrast, blockade of CB1Rs can decrease the rewarding

THC the active ingredient in Cannabis attaches to cannabinoid receptors throughout the body. Several areas of the brain have high densities of these receptors, which helps explain the different effects of the drug. The receptors work through nerve cells communicating by way of chemical messaging across contact points called synapses. THC attaches to cannabinoid receptors and therefore modifies nerve

The cannabinoid receptor type 1 (CB1) is a G protein-coupled receptor mainly expressed in the central and peripheral nervous system. The CB1 receptor is activated by the endocannabinoid neurotransmitters anandamide and 2-arachidonoylglycerol (2-AG). The CB1 receptor has been implicated in the maintenance of homeostasis in health and disease [2]. The CB1 receptor plays vital roles in modulating neurotransmitter release by preventing the development of excessive neuronal activity, reducing pain and other inflammatory symptoms [2].

Although the medicinal and ceremonial consumption of cannabis has a long history going back centuries, and despite the fact that it is presently among the most widely recreationally used substance, only within the last few decades have the underlying constituents of cannabis sativa and its biological mechanisms begun to be investigated in earnest (Gorzalka & Hill & Hillard, 2008; Akirav, 2011). It wasn’t until the early nineties, with the discovery of specialized cannabinoid receptors and their corresponding endogenous ligands, that the endogenous cannabinoid (eCB) system began to be investigated with renewed scientific vigor (Lopez, 2010; Zuardi, 2008). The outpouring of data, while often times contradictory and perplexing, has lead to some

Many regions of the brain contain cannabinoid receptors, of which anandamide molecules, concerned with regulating mood, appetite and emotions, naturally bind to. Cannabis contains an active ingredient known as ‘delta-9-tetrahydrocannabonic’ (THC), and when smoked or eaten, the THC imitates the activity of anandamide by binding to cannabinoid receptors on nerve cells, and therefore influences