The Effect Of Mineral Nutrition On The Toxicity Of Metals

1615 WordsAug 27, 20167 Pages
There is a vast amount of literature which indicates that the mineral nutrition has an important role in the toxicity of metals (Pond and Walker, 1972, 1975; Larson and Piscator, 1971; Petering et al., 1971, 1974; 1977; Hamilton and Valberg, 1974; Doyle and Pfander, 1975; Hastings et al., 1976; Waldron and Stofen, 1974). It is true, especially to those micronutrients which are essential such as zinc, copper, iron with respect to toxicity of certain metals like cadmium, arsenic, lead etc. It is assumed that the dietary intake of metals in excessive such as copper, iron and zinc will be protective against the toxic effects of the heavy metals like lead. The deficiency of calcium and other essential elements result in the enhanced toxicity of lead and cadmium [ref]. There had been difficulty in evaluating the role of essential nutrients like zinc, iron, copper etc on the toxicity of heavy metals, perhaps due to differences in the animal models choosen, the route of administration and other metabolic and physiological differences which leads to variable results between studies. Lead zinc relationships Cerklewski and Forbes (1976) reported that rats when fed a diet having low levels of zinc and containing 200 ppm of lead cause a marked increase in the lead levels of tibia and urinary 8-aminolevulinic acid (ALA). Further it has been observed that the lead levels of tibia and urinary ALA has reduced greatly when the zinc content of the diet was raised to optimal or super-optimal

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