sleep? Why, as a species, do we need to sleep? Beyond that of feeling tired, science has yet to come to a unanimous decision as to the reasons behind the human race needing to sleep. T. Porkka-Heiskanen, K.M. Zitting, and H.K. Wigren reviewed various research studies and compiled a report of some of the various theories as to why humans need sleep and the potential effects of lack of sleep on the human body, both physically and psychologically. Sleep has been identified in all species studied thus
ACC1 and ACC2, such as the lipophilic ligand efficiency (LipE), measured lipophilicity (ElogD), human liver microsomal incubation (HLM), and passive permeability (Papp) in Ralph Russ canine kidney cells.6 1,9-Diazaspiro[5.5]undecan-2-one 1c (Fig. 4) was selected for a SAR study of the effects of