The Effects Of Citalopram On Depressive Illness, Panic Disorder And Mood Disorders

All antidepressants work in a similar way, though there are various types of antidepressants—often called “families”—that each work a bit differently. They all, however, increase the brain’s concentration of various neurotransmitters. Antidepressants are psychiatric medications given to patients with depressive disorders to alleviate symptoms. They correct chemical imbalances of neurotransmitters in the brain which probably cause changes in mood and behavior. Antidepressants may be used for a wide range of psychiatric conditions, including social anxiety disorder, anxiety disorders. Antidepressants were initially developed in the 1950s. Their use has become progressively more common over the last twenty years. Generally speaking, anti­psychotic

The cerebral cortex directs functions like speech, behavior, reactions, movement, thinking, and learning. In fact, some research suggests that bipolar disorder originates with problems with the thalamus, which links sensory input to good and bad feelings. The hippocampus also affects depression. It, like the amygdala, is part of the limbic system. It is vital in processing long-term memory. This section of the brain registers recurring fear. In people with clinical depression, the hippocampus is much smaller. Research suggests, even, that ongoing exposure to stress impairs the growth of nerve cells in this part of the brain. One of the most important jobs of the brain is to process senses, through neurons. Neurotransmitters are specific substances that help relay information to the brain. Scientists have identified many neurotransmitters that affect depression. A lack or excess of the neurotransmitters acetylcholine, serotonin, norepinephrine, dopamine, glutamate, lithium carbonate and gamma-aminobutyric acid are thought to contribute to depression. Acetylcholine is involved in learning and enhances memory. Serotonin helps regulate sleep, appetite, and mood, and inhibits pain. Research shows the idea that many depressed people have reduced levels of serotonin. Low levels of a byproduct of serotonin have been linked to a high risk for suicide. Norepinephrine is a neurotransmitter which constricts blood vessels and raises blood pressure. An excess in

Major depressive disorder is one of the most common mental disorders, with a 12-month prevalence of 6.7% of adults in the United States (NIMH). There is no definite etiology of depression, but several risk factors have been identified. Functional and structural changes in the brain have also been explored. The most common treatment for depression is the use of drugs that act on monoamine transmitters, including norepinephrine, dopamine, and serotonin. Decreases in these transmitters, especially serotonin, were hypothesized to play an important role in the cause of depression (Breedlove & Watson, 2013). The serotonin hypothesis led to the development of selective-serotonin reuptake inhibitors (SSRIs), which increase the amount of serotonin in the brain. Further research suggests that the serotonin hypothesis is not entirely accurate and the neurobiology of depression is much more complex. The “chemical imbalance” explanation of depression may not reflect the full range of causes and may be given greater credibility by patients and doctors than is supported by evidence based research.

The brain chemical serotonin is connected to many body functions such as sleep, wakefulness, eating, sexual activity, impulsivity, learning, and memory. Researchers believe that abnormal

The main components of the synapses are as follows: The Axon terminal, found at the end of the Axon, passes neurotransmitters to other neurons via synaptic transmission. Synaptic Vesicles contain neurotransmitters within the Axon. Neurotransmitters themselves are chemical messengers that travel through the neurons and activate receptors on the receiving cell. The neurotransmitters are diffused through the synaptic cleft—a region between the two neurons and gap the neurotransmitter needs to cross to make it to the receiving cell. Said receiving cell is what receives the neurotransmitters and starts the process over again. The receptors on the cell are structures that receive the neurotransmitters and

Serotonin is found in the gastrointestinal (GI) tract and the central nervous system (CNS). Serotonin in the CNS affects learning, appetite, mood, and sleep. In the GI, it is used to control appetite and digestion. A few feelings come as a result of serotonin, such as happiness, relaxation, and security. Low serotonin levels can cause depression, anxiety, and

The belief is that antidepressants work by increasing levels of a group of chemicals in the brain called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, can improve mood and emotion, although we do not yet fully understand this process

There are three different types of antidepressants; SSRIS, SNRIS, and Tricyclics (Steven M. Melemis, PH.D.M.D.). This shows that the same antidepressant medication doesn't work for everyone, however, there hope because they can always try a different type. Research shows,”Antidepressants are designed to block various aspects of the synaptic transmission process in serotonin, norepinephrine and dopamine-containing neurons in the brain. This increases the levels of these neurotransmitters. By increasing the levels of these neurotransmitters, mood and emotions should stabilize and perhaps return to normal” (Craig Freudenrich, PH.D.). This piece of evidence proves that antidepressants can help a person cope with their emotions by reducing the negative chemicals and increasing the neurotransmitters in a person's brain. Even though antidepressants can be very successful at treating depression, there are still some side effects that

These drugs, known as selective serotonin reuptake inhibitors (SSRI), affect neurotransmitter serotonin levels by inhibiting the body’s ability to remove serotonin when the brain tells it to.

An action potential travels down the axon of the presynaptic neuron; once the action potential reaches the axon terminal synaptic vesicles migrate toward the synapse. They then release neurotransmitters into the synaptic cleft. The

Doctors also prescribe Selective Serotonin Reuptake Inhibitors(SSRI) to individuals suffering from depression, but the same ailment can be treated with amino acid supplements. Some examples of SSRIs are Prozac, Paxil, Zoloft and Celexa. SSRIs increase the amount of serotonin in the synapse by blocking its reabsorption, helping the symptoms of depression improve. According to the American Academy of Family Physicians, benzodiazepines lose their therapeutic anti-anxiety effect after 4 to 6 months of regular use. Dr. White, clinical psychologist and a certified neurotherapist, compares antidepressants to a foreign chemical. She is completely against the use of SSRIs because it blocks the reuptake of the serotonin into the neuron. In simple words,

al., 2004). As it falls under the SSRI class of antidepressants, escitalopram is believed to treat symptoms of depression by raising levels of a neurotransmitter called serotonin in the brain (Garnock-Jones & Mccormack, 2010). As an SSRI, escitalopram blocks reuptake of serotonin into presynaptic neurons, causing more serotonin to be present in the brain and ease depression symptoms (Garnock-Jones & Mccormack, 2010).

The newest medications used to suppress depression are collectively known as selective serotonin inhibitors (SSRIs). These drugs work by altering the

The neurotransmitters norepinephrine, serotonin is also thought to play a role in depression (Porth 1371).  There are decreased levels of these neurotransmitters present in the pre and post synaptic cleft.  Dopamine levels have been studied and increased levels of dopamine are found in mania and decreased levels in depression (Porth 1372).

Neurotransmitters involved in depression include norepinephrine, dopamine, and serotonin. An imbalance of hormones may also play a role in depression. Many depressed people have higher than normal levels of hydrocortisone, a hormone secreted by the adrenal gland in response to stress. In addition, an underactive or overactive thyroid gland can lead to depression.4