The Effects Of Diabetes On The Body 's Immune System

When the blood glucose levels rise above the optimum, the pancreas detects this, and sends a metabolic signal for the pancreas to produce insulin in the beta cells. The beta cells are a part of a cluster of cells called the Islets of Langerhan. The hormone insulin is made here because the pancreas is a part of the endocrine system. (4) Insulin helps our cells convert glucose into energy, and it helps our bodies store extra glucose for use later. Insulin does this by turning the extra food into larger packages of glucose called glycogen. Glycogen is stored in the liver and muscles. When the body consumes food the pancreas will produce more insulin than normal as more is needed, and less insulin when it is not needed as much. (7)

cells which can help treat people suffering from diabetes. Even tissues can be grown again by

A beta cell-specific autoimmune process is the beginning of the destruction of the beta cells that produce insulin.

stem cells were discovered a long ago that they can be beneficial for fighting against the killer diseases but after passing of two decades of the discovery it has been profound that (hESCs) are being tried as a treatment for two noteworthy illnesses: heart fail and type 1 diabetes.

Islets of Langerhans contain beta cells and are located within the pancreas. Beta cells produce insulin which is needed to metabolize glucose within the body.

The type 1 Diabetes that Ava lives with differentiates from type 2 Diabetes in that it is characterized by the complete autoimmune destruction of the pancreatic Beta (B) cells that produce and secrete Insulin in the Islet’s of Langerhans (Craft & Gordon, 2015, pg253). By contrast, type 2 Diabetes is a combination of B cell destruction, B cell dysfunction, and insulin resistance (Turner & Wass, 2009, pg803). The Beta cells of a non-Diabetic person would rapidly respond to glucose, however in type 1 Diabetes antibodies are produced against the body’s own B cells and consequently all the Islets are destroyed (Montague, 1983, pg50 and Craft & Gordon, 2015, pg253). This results in the failure of negative feedback loops in maintaining the body’s

Diabetes mellitus (DM) is a condition in the body that is related to a faulty metabolism. It means that the body’s metabolism is not functioning properly, which leads to adverse effects in the health. The food we ingest, gets broken down into blood sugar (glucose), which is what fuels our body in the form of energy. This converted glucose needs to enter our cells so that it can be used for energy and growth. And in order for the glucose to enter our cells, there needs to be insulin present, which the beta cells of the pancreas is responsible for producing. This hormone is responsible for maintaining glucose level in the blood. It allows the body cells to use glucose as a main

What is Diabetes? Diabetes affects approximately 6% of Americans, 17 million people, and alarmingly 5.9 million of them are unaware that they have this chronic disease. Diabetes is a disease that is classified into two central types, type 1 and type 2. The disease results in the body being incapable of producing enough insulin and also causes an inability to use the insulin that has produced. Type 1 diabetes is considered to be an autoimmune disease that has the ability to destroy the facility of the pancreas to produce insulin. Type 2 diabetes is a more complex disease that is characterized by elevated blood glucose levels which causes the body to produce but causes an inability to properly use what has been produced. Although millions of Americans suffer from this chronic disease, which can immerge in early childhood with the little-known cause of the disease, it is believed that diabetes is triggered by poor diet, exercise, obesity and inherited through genetics. Diabetes is a very manageable disease when it detected early but left untreated and managed it can possibly lead to death. A poor diet and obesity are a few of the leading causes of type 2 diabetes, which is the result of nutritional deficiencies. An individual with a body mass index of thirty or more increases their chances of developing type 2 diabetes. Currently in America, younger children have a greater risk factor of developing type 2 diabetes due to long term diets that consists of high saturated

Destruction of beta cells > Beta cells decline> insulin secretion decreases until insulin is no longer available to maintain normal blood glucose levels.>Beta cells

Insulin is produced by beta cells in pancreas. It is a hormone that helps our body to use glucose as energy. After food consumption, carbohydrates will be broken down into glucose. Insulin helps the cells in our body to absorb the glucose from the bloodstream to use it as energy. Furthermore, insulin can also help to balance our blood glucose level. Insulin signals the liver to convert glucose into glycogen to store it when the blood glucose level is high. The stored glucose will only be released when the blood glucose level is low.

Diabetes has several negative effects on the body. Diabetes can effect wound healing, infection, and weight. When it comes to diabetes, many factors play a role in the reasons why wound healing takes place slowly. The most evident factor, and the root of most of the other factors, is high blood sugar levels. The high blood sugar levels lead to artery stiffness and vessel narrowing. Being that the vessels are narrowed, blood circulation will be very poor. Blood circulation involves red blood cells and white blood cells. If the circulation is poor, white blood cell will not be able to be as affective when fighting off pathogens. Another problem is diabetic neuropathy, and this is basically when those with diabetes loose feeling sensations because

In this fast paced world we live in today, most if not all people know someone who has been affected by diabetes. Diabetes is a disease that affects a person everyday life, and multifunctional body systems. Diabetes is a diseases where your body does not produce enough insulin, or is insulin resistance. There are two different types of this disease.

Both type 1 and 2 diabetics result from a complete or partial loss of beta cell number and function. Currently they are working on regenerating human beta cells. They are also in trail with the creation of an artificial pancreas. This is to replace the damaged pancreas so that the new pancreas can provide insulin to the

Ethical concerns regarding the use of embryo-derived embryonic stem cells (ES), and the immune response elicited by differentiated ES cells, are being circumvented by using induced pluripotential stem cells (iPSCs) derived from patients’ somatic cells. These can be differentiated into other cell types including pancreatic -cells for diabetics. Unfortunately aspects of iPSC DNA & regulation of differentiation impair the production of cells for transplant. Understanding the role of micro RNAs in iPSC differentiation could improve the therapeutic application of iPSCs.

Islet cells in the pancreas are known to be the chief for production of insulin